Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown, С. 327 - 370
Опубликована: Май 7, 2024
Abstract
‘The
neurology
of
anxiety—planning
circuits’
extends
the
anxiolytic-derived
neuropsychology
survival
circuits
(including
hippocampus
and
anterior
cingulate
cortex)
to
goal
planning
prefrontal
cortex.
It
first
discusses
results
from
issues
with
early
work
using
lesions
as
treatments
neurotic
disorders
considers
evolution
frontal
cortex
in
context
defence
hierarchy
emphasizing
fact
that
‘deeper’
areas
are
phylogenetically
more
ancient.
then
details
anatomy
cortex,
importance
active
memory
dorsal
ventral
trend
perception-action
cycles,
control
conflict.
also
describes
a
‘mesial’
linked
internal
insula
source
monitoring
arousal/attention
outputs
Goal
Inhibition
System
(GIS).
The
final
sections
integrate
these
data
into
new,
extended,
2D
theory
systems.
Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 7, 2024
Abstract
The
Neuropsychology
of
Anxiety
first
appeared
in
1982
as
the
volume
Oxford
Psychology
Series,
and
it
quickly
established
itself
classic
work
on
subject.
It
second
edition
(appearing
2000)
have
been
cited
at
a
steadily
increasing
rate
passing
500/year
2017.
field
has
continued
to
expand
last
quarter
century
necessitating
this
third
edition.
This
completely
updated
revised
(with
many
figures
converted
colour)
retains
original
core
concepts
while
expanding
often
simplifying
details.
includes
new
chapter
prefrontal
cortex,
which
integrates
frontal
hippocampal
views
anxiety
an
extensively
modified
personality
providing
basis
for
further
developments
Reinforcement
Sensitivity
Theory.
book
is
essential
postgraduate
students
researchers
experimental
psychology
neuroscience,
well
all
clinical
psychologists
psychiatrists.
Cell Reports,
Год журнала:
2024,
Номер
43(6), С. 114341 - 114341
Опубликована: Июнь 1, 2024
The
dorsal
raphe
nucleus
(DRN)
is
implicated
in
psychiatric
disorders
that
feature
impaired
sensitivity
to
reward
amount,
impulsivity
when
facing
delays,
and
risk-seeking
confronting
uncertainty.
However,
it
has
been
unclear
whether
how
DRN
neurons
signal
delay,
uncertainty
during
multi-attribute
value-based
decision-making,
where
subjects
consider
these
attributes
make
a
choice.
We
recorded
as
monkeys
chose
between
offers
whose
attributes,
namely
expected
uncertainty,
varied
independently.
Many
signaled
offer
this
population
tended
integrate
the
manner
reflected
monkeys'
preferences
for
After
response
post-decision
feedback,
same
signed
prediction
errors,
suggesting
broader
role
tracking
value
across
task
epochs
behavioral
contexts.
Our
data
illustrate
participates
computations,
guiding
theories
about
of
decision-making
disease.
PLoS ONE,
Год журнала:
2021,
Номер
16(6), С. e0252345 - e0252345
Опубликована: Июнь 4, 2021
Calcium
imaging
has
led
to
discoveries
about
neural
correlates
of
behavior
in
subcortical
neurons,
including
dopamine
(DA)
neurons.
However,
spike
inference
methods
have
not
been
tested
most
populations
To
address
this
gap,
we
simultaneously
performed
calcium
and
electrophysiology
DA
neurons
brain
slices
applied
a
recently
developed
algorithm
the
GCaMP
fluorescence.
This
revealed
that
individual
spikes
can
be
inferred
accurately
population.
Next,
vivo
from
these
during
Pavlovian
conditioning,
as
well
navigation
virtual
reality.
In
both
cases,
quantitatively
recapitulated
previous
electrophysiological
observations.
Our
work
provides
validated
approach
infer
implies
aspects
tonic
phasic
patterns
recovered.
Affiliative
social
connections
facilitate
well-being
and
survival
in
numerous
species.
Engaging
interactions
requires
positive
or
negative
motivational
drive,
elicited
through
coordinated
activity
across
neural
circuits.
However,
the
identity,
interconnectivity,
functional
encoding
of
information
within
these
circuits
remains
poorly
understood.
Here,
we
focus
on
downstream
projections
dorsal
raphe
nucleus
(DRN)
dopamine
neurons
(DRN
DAT
),
which
previously
implicated
motivation
alongside
an
aversive
affective
state.
We
show
that
three
prominent
DRN
–
to
bed
stria
terminalis
(BNST),
central
amygdala
(CeA),
posterior
basolateral
(BLP)
play
separable
roles
behavior,
despite
substantial
collateralization.
Photoactivation
-CeA
projection
promoted
behavior
photostimulation
-BNST
exploratory
while
-BLP
supported
place
avoidance,
suggesting
a
Downstream
regions
showed
diverse
receptor
expression,
poising
act
dopamine,
neuropeptide,
glutamate
transmission.
Furthermore,
ex
vivo
effect
neuron
excitability
depended
region
baseline
cell
properties,
resulting
excitatory
responses
BNST
cells
CeA
BLP.
Finally,
microendoscopic
cellular-resolution
recordings
with
revealed
correlation
between
excited
by
stimuli–
increased
tone
may
recruit
different
ensembles.
Collectively,
circuit
features
coordinated,
but
flexible,
response
presence
stimuli
can
be
flexibly
guided
based
internal
homeostatic
need
state
individual.
Affiliative
social
connections
facilitate
well-being
and
survival
in
numerous
species.
Engaging
interactions
requires
positive
or
negative
motivational
drive,
elicited
through
coordinated
activity
across
neural
circuits.
However,
the
identity,
interconnectivity,
functional
encoding
of
information
within
these
circuits
remains
poorly
understood.
Here,
we
focus
on
downstream
projections
dorsal
raphe
nucleus
(DRN)
dopamine
neurons
(DRN
DAT
),
which
previously
implicated
motivation
alongside
an
aversive
affective
state.
We
show
that
three
prominent
DRN
–
to
bed
stria
terminalis
(BNST),
central
amygdala
(CeA),
posterior
basolateral
(BLP)
play
separable
roles
behavior,
despite
substantial
collateralization.
Photoactivation
-CeA
projection
promoted
behavior
photostimulation
-BNST
exploratory
while
-BLP
supported
place
avoidance,
suggesting
a
Downstream
regions
showed
diverse
receptor
expression,
poising
act
dopamine,
neuropeptide,
glutamate
transmission.
Furthermore,
ex
vivo
effect
neuron
excitability
depended
region
baseline
cell
properties,
resulting
excitatory
responses
BNST
cells
CeA
BLP.
Finally,
microendoscopic
cellular-resolution
recordings
with
revealed
correlation
between
excited
by
stimuli–
increased
tone
may
recruit
different
ensembles.
Collectively,
circuit
features
coordinated,
but
flexible,
response
presence
stimuli
can
be
flexibly
guided
based
internal
homeostatic
need
state
individual.
Midbrain
and
striatal
dopamine
signals
have
been
extremely
well
characterized
over
the
past
several
decades,
yet
novel
functions
in
reward
learning
motivation
continue
to
emerge.
A
similar
characterization
of
real-time
sub-second
areas
outside
striatum
has
limited.
Recent
advances
fluorescent
sensor
technology
fiber
photometry
permit
measurement
binding
correlates,
which
can
divulge
basic
signaling
non-striatal
terminal
regions,
like
dorsal
bed
nucleus
stria
terminalis
(dBNST).
Here,
we
record
GRAB
DA
dBNST
during
a
Pavlovian
lever
autoshaping
task.
We
observe
greater
cue-evoked
sign-tracking
(ST)
compared
goal-tracking/intermediate
(GT/INT)
rats
magnitude
decreases
immediately
following
reinforcer-specific
satiety.
When
deliver
unexpected
rewards
or
omit
expected
rewards,
find
that
encode
bidirectional
prediction
errors
GT/INT
rats,
but
only
positive
ST
rats.
Since
sign-
goal-tracking
approach
strategies
are
associated
with
distinct
drug
relapse
vulnerabilities,
examined
effects
experimenter-administered
fentanyl
on
associative
encoding.
Systemic
injections
do
not
disrupt
cue
discrimination
generally
potentiate
signals.
These
results
reveal
multiple
correlates
depend
strategy
employed.
European Journal of Neuroscience,
Год журнала:
2023,
Номер
59(6), С. 1099 - 1140
Опубликована: Окт. 17, 2023
Abstract
Dopamine,
a
catecholamine
neurotransmitter,
has
historically
been
associated
with
the
encoding
of
reward,
whereas
its
role
in
aversion
received
less
attention.
Here,
we
systematically
gathered
vast
evidence
dopamine
simplest
forms
aversive
learning:
classical
fear
conditioning
and
extinction.
In
past,
crude
methods
were
used
to
augment
or
inhibit
study
relationship
More
advanced
techniques
such
as
conditional
genetic,
chemogenic
optogenetic
approaches
now
provide
causal
for
dopamine's
these
learning
processes.
Dopamine
neurons
encode
conditioned
stimuli
during
extinction
convey
signal
via
activation
D
1–4
receptor
sites
particularly
amygdala,
prefrontal
cortex
striatum.
The
coordinated
receptors
allows
continuous
formation,
consolidation,
retrieval
updating
memory
dynamic
reciprocal
manner.
Based
on
reviewed
literature,
conclude
that
is
crucial
contributes
way
comparable
reward.
