Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner DOI Creative Commons
Masaya Harada, Laia Serratosa Capdevila,

Maria Wilhelm

и другие.

eLife, Год журнала: 2024, Номер 12

Опубликована: Апрель 3, 2024

Dopamine and orexins (hypocretins) play important roles in regulating reward-seeking behaviors. It is known that hypothalamic orexinergic neurons project to dopamine the ventral tegmental area (VTA), where they can stimulate dopaminergic neuronal activity. Although there are reciprocal connections between systems, whether how regulates activity of orexin currently not known. Here we implemented an opto-Pavlovian task which mice learn associate a sensory cue with optogenetic neuron stimulation investigate relationship release lateral hypothalamus (LH). We found be evoked LH upon VTA also naturally by presentation after learning. Furthermore, could upregulated local terminals way partially dependent on D2 receptors (DRD2). Our results reveal previously unknown coding reward expectation unveil orexin-regulatory axis mediated inputs LH.

Язык: Английский

The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species DOI Creative Commons

Yana van de Poll,

Yasmin Cras,

Tommas J. Ellender

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Авг. 30, 2023

The bed nucleus of the stria terminalis (BNST), as part extended amygdala, has become a region increasing interest regarding its role in numerous human stress-related psychiatric diseases, including post-traumatic stress disorder and generalized anxiety amongst others. BNST is sexually dimorphic highly complex structure already evident by anatomy consisting 11 to 18 distinct sub-nuclei rodents. Located ventral forebrain, anatomically functionally connected many other limbic structures, hypothalamic nuclei, basal ganglia, hippocampus. Given this extensive connectivity, thought play central critical integration information on hedonic-valence, mood, arousal states, processing emotional information, general shape motivated stress/anxiety-related behavior. Regarding regulating behavior anterolateral group (BNSTALG) been extensively studied contains wide variety neurons that differ their electrophysiological properties, morphology, spatial organization, neuropeptidergic content input output synaptic organization which activity function. In addition great diversity, further species-specific differences are multiple levels. For example, classic studies performed adult rat brain identified three neuron types (Type I-III) based properties ion channel expression. Whilst similar have animal species, such mice non-human primates macaques, cross-species comparisons revealed intriguing comparative prevalence BNSTALG well morphological differences. tremendous complexity levels, comprehensive elucidation circuitry major challenge. present Review we bring together highlight key structure, functional profiles between species with aim facilitate future important relation disease.

Язык: Английский

Процитировано

18
Past, Present, and Future of Tools for Dopamine Detection DOI
Yufeng Zheng, Yulong Li

Neuroscience, Год журнала: 2023, Номер 525, С. 13 - 25

Опубликована: Июль 5, 2023

Язык: Английский

Процитировано

11
Dopamine in the dorsal bed nucleus of stria terminalis signals Pavlovian sign-tracking and reward violations DOI Creative Commons
Utsav Gyawali, David Martin,

Fangmiao Sun

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Май 26, 2023

Midbrain and striatal dopamine signals have been extremely well characterized over the past several decades, yet novel functions in reward learning motivation continue to emerge. A similar characterization of real-time sub-second areas outside striatum has limited. Recent advances fluorescent sensor technology fiber photometry permit measurement binding correlates, which can divulge basic signaling non-striatal terminal regions, like dorsal bed nucleus stria terminalis (dBNST). Here, we record GRAB DA dBNST during a Pavlovian lever autoshaping task. We observe greater cue-evoked sign-tracking (ST) compared goal-tracking/intermediate (GT/INT) rats magnitude decreases immediately following reinforcer-specific satiety. When deliver unexpected rewards or omit expected rewards, find that encode bidirectional prediction errors GT/INT rats, but only positive ST rats. Since sign- goal-tracking approach strategies are associated with distinct drug relapse vulnerabilities, examined effects experimenter-administered fentanyl on associative encoding. Systemic injections do not disrupt cue discrimination generally potentiate signals. These results reveal multiple correlates depend strategy employed.

Язык: Английский

Процитировано

7
Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner DOI Creative Commons
Masaya Harada, Laia Serratosa Capdevila,

Maria Wilhelm

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Окт. 18, 2023

Dopamine and orexins (hypocretins) play important roles in regulating reward-seeking behaviors. It is known that hypothalamic orexinergic neurons project to dopamine the ventral tegmental area (VTA), where they can stimulate dopaminergic neuronal activity. Although there are reciprocal connections between systems, whether how regulates activity of orexin currently not known. Here we implemented an opto-Pavlovian task which mice learn associate a sensory cue with optogenetic neuron stimulation investigate relationship release lateral hypothalamus (LH). We found be evoked LH upon VTA also naturally by presentation after learning. Furthermore, could upregulated local terminals way partially dependent on D2 receptors (DRD2). Our results reveal previously unknown coding reward expectation unveil orexin-regulatory axis mediated inputs LH.

Язык: Английский

Процитировано

3
Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner DOI Creative Commons
Masaya Harada, Laia Serratosa Capdevila,

Maria Wilhelm

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 13, 2023

Abstract Dopamine and orexins (hypocretins) play important roles in regulating reward-seeking behaviors. It is known that hypothalamic orexinergic neurons project to dopamine the ventral tegmental area (VTA), where they can stimulate dopaminergic neuronal activity. Although there are reciprocal connections between systems, whether how regulates activity of orexin currently not known. Here we implemented an opto-Pavlovian task which mice learn associate a sensory cue with optogenetic neuron stimulation investigate relationship release LH. We found be evoked LH upon VTA neurons, also naturally by presentation after learning. Furthermore, could upregulated local terminals way partially dependent on D2 receptors (DRD2). Our results reveal previously unknown coding reward expectation unveil orexin-regulatory axis mediated inputs Highlights Optical DA sufficient elicit Pavlovian-like transient NAc encodes both negative positive prediction errors positively modulates locally D2R

Язык: Английский

Процитировано

1
Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner DOI Open Access
Masaya Harada, Laia Serratosa Capdevila,

Maria Wilhelm

и другие.

Опубликована: Март 11, 2024

Optical VTA DA neuron stimulation is sufficient to elicit a Pavlovian-like dopamine transient in the NAcDopamine LH encodes both negative and positive reward prediction errorsDopamine positively modulates orexin neuronal activity locally D2R dependent wayDopamine orexins (hypocretins) play important roles regulating reward-seeking behaviors. It known that hypothalamic orexinergic neurons project ventral tegmental area (VTA), where they can stimulate dopaminergic activity. Although there are reciprocal connections between systems, whether how regulates of currently not known. Here we implemented an opto-Pavlovian task which mice learn associate sensory cue with optogenetic investigate relationship release LH. We found be evoked upon neurons, also naturally by presentation after learning. Furthermore, could upregulated local terminals way partially on D2 receptors (DRD2). Our results reveal previously unknown coding expectation unveil orexin-regulatory axis mediated inputs

Язык: Английский

Процитировано

0
Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner DOI Creative Commons
Masaya Harada, Laia Serratosa Capdevila,

Maria Wilhelm

и другие.

eLife, Год журнала: 2024, Номер 12

Опубликована: Апрель 3, 2024

Dopamine and orexins (hypocretins) play important roles in regulating reward-seeking behaviors. It is known that hypothalamic orexinergic neurons project to dopamine the ventral tegmental area (VTA), where they can stimulate dopaminergic neuronal activity. Although there are reciprocal connections between systems, whether how regulates activity of orexin currently not known. Here we implemented an opto-Pavlovian task which mice learn associate a sensory cue with optogenetic neuron stimulation investigate relationship release lateral hypothalamus (LH). We found be evoked LH upon VTA also naturally by presentation after learning. Furthermore, could upregulated local terminals way partially dependent on D2 receptors (DRD2). Our results reveal previously unknown coding reward expectation unveil orexin-regulatory axis mediated inputs LH.

Язык: Английский

Процитировано

0