The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear

Frontiers in Behavioral Neuroscience, Год журнала: 2015, Номер 9

Опубликована: Ноя. 9, 2015

Once acquired, a fearful memory can persist for lifetime. Although learned fear be extinguished, extinction memories are fragile. The resilience of to may contribute the maintenance disorders and anxiety, including post-traumatic stress disorder (PTSD). As such, considerable effort has been placed on understanding neural circuitry underlying acquisition, expression, emotional in rodent models as well humans. A triad brain regions, prefrontal cortex, hippocampus, amygdala, form an essential circuit involved conditioning extinction. Within this circuit, cortex is thought exert top-down control over subcortical structures regulate appropriate behavioral responses. Importantly, division labor proposed which prelimbic (PL) infralimbic (IL) subdivisions medial (mPFC) expression suppression rodents, respectively. Here, we critically review anatomical physiological evidence that led dichotomy function within mPFC. We propose under some conditions, PL IL act concert, exhibiting similar patterns activity response aversive conditioned stimuli during or inhibition fear. This stem from common synaptic inputs, parallel downstream outputs, cortico-cortical interactions. Despite functional covariation, these mPFC still coding largely opposing outcomes, with biased towards suppression.

Язык: Английский

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Basomedial amygdala mediates top-down control of anxiety and fear

Nature, Год журнала: 2015, Номер 527(7577), С. 179 - 185

Опубликована: Ноя. 1, 2015

Язык: Английский

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Fear Memory

Physiological Reviews, Год журнала: 2016, Номер 96(2), С. 695 - 750

Опубликована: Март 17, 2016

Fear memory is the best-studied form of memory. It was thoroughly investigated in past 60 years mostly using two classical conditioning procedures (contextual fear and to a tone) one instrumental procedure (one-trial inhibitory avoidance). formed hippocampus avoidance), basolateral amygdala (inhibitory lateral (conditioning tone). The circuitry involves, addition, pre- infralimbic ventromedial prefrontal cortex, central subnuclei, dentate gyrus. learning models, notably avoidance, have also been very useful for analysis biochemical mechanisms consolidation as whole. These studies capitalized on vitro observations long-term potentiation other kinds plasticity. effect large number drugs has intensively studied, often prelude investigation effects anxiety. extinction involves an extent reversal flow information mentioned structures used therapy posttraumatic stress disorder memories general.

Язык: Английский

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Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(9), С. 535 - 551

Опубликована: Июль 27, 2018

Язык: Английский

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Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex

Neuroscience, Год журнала: 2015, Номер 321, С. 197 - 209

Опубликована: Июль 21, 2015

Highlights•BLA projections to the mPFC were targeted using optogenetic tools in mice.•Stimulation increased anxiety-like behavior and decreased social interaction.•Inhibition interaction.AbstractThe basolateral amygdala (BLA) medial prefrontal cortex (mPFC) modulate anxiety behaviors. It remains be elucidated, however, whether direct from BLA play a functional role these We used approaches behaving mice either activate or inhibit inputs during behavioral assays that assess interaction. Channelrhodopsin-2 (ChR2)-mediated activation of produced anxiogenic effects elevated plus maze open field test, whereas halorhodopsin (NpHR)-mediated inhibition anxiolytic effects. Furthermore, BLA-mPFC pathway reduced interaction resident-intruder facilitated These results establish causal relationship between activity bidirectional modulation anxiety-related

Язык: Английский

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A Network Model of the Emotional Brain

Trends in Cognitive Sciences, Год журнала: 2017, Номер 21(5), С. 357 - 371

Опубликована: Март 28, 2017

Язык: Английский

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Stress and Fear Extinction

Neuropsychopharmacology, Год журнала: 2015, Номер 41(1), С. 58 - 79

Опубликована: Июнь 24, 2015

Язык: Английский

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Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

Physiological Reviews, Год журнала: 2020, Номер 101(2), С. 611 - 681

Опубликована: Сен. 24, 2020

This article reviews the behavioral neuroscience of extinction, phenomenon in which a behavior that has been acquired through Pavlovian or instrumental (operant) learning decreases strength when outcome reinforced it is removed. Behavioral research indicates neither nor operant extinction depends substantially on erasure original but instead new inhibitory primarily expressed context learned, as exemplified by renewal effect. Although nature inhibition may differ and either case decline responding depend both generalization decrement correction prediction error. At neural level, requires tripartite circuit involving amygdala, prefrontal cortex, hippocampus. Synaptic plasticity amygdala essential for learning, cortical neurons encoding fear memories involved retrieval. Hippocampal-prefrontal circuits mediate relapse phenomena, including renewal. Instrumental involves distinct ensembles corticostriatal, striatopallidal, striatohypothalamic well their thalamic returns (extinction) excitatory (renewal other phenomena) control over responding. The field made significant progress recent decades, although fully integrated biobehavioral understanding still awaits.

Язык: Английский

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Rethinking Extinction

Neuron, Год журнала: 2015, Номер 88(1), С. 47 - 63

Опубликована: Окт. 1, 2015

Язык: Английский

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Fear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants

Neuroscience & Biobehavioral Reviews, Год журнала: 2018, Номер 88, С. 16 - 25

Опубликована: Март 11, 2018

Язык: Английский

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