Know safety, no fear DOI
Susan Sangha, María M. Diehl, Hadley C. Bergstrom

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2019, Номер 108, С. 218 - 230

Опубликована: Ноя. 16, 2019

Язык: Английский

The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear DOI Creative Commons
Thomas F. Giustino, Stephen Maren

Frontiers in Behavioral Neuroscience, Год журнала: 2015, Номер 9

Опубликована: Ноя. 9, 2015

Once acquired, a fearful memory can persist for lifetime. Although learned fear be extinguished, extinction memories are fragile. The resilience of to may contribute the maintenance disorders and anxiety, including post-traumatic stress disorder (PTSD). As such, considerable effort has been placed on understanding neural circuitry underlying acquisition, expression, emotional in rodent models as well humans. A triad brain regions, prefrontal cortex, hippocampus, amygdala, form an essential circuit involved conditioning extinction. Within this circuit, cortex is thought exert top-down control over subcortical structures regulate appropriate behavioral responses. Importantly, division labor proposed which prelimbic (PL) infralimbic (IL) subdivisions medial (mPFC) expression suppression rodents, respectively. Here, we critically review anatomical physiological evidence that led dichotomy function within mPFC. We propose under some conditions, PL IL act concert, exhibiting similar patterns activity response aversive conditioned stimuli during or inhibition fear. This stem from common synaptic inputs, parallel downstream outputs, cortico-cortical interactions. Despite functional covariation, these mPFC still coding largely opposing outcomes, with biased towards suppression.

Язык: Английский

Процитировано

474

Basomedial amygdala mediates top-down control of anxiety and fear DOI
Avishek Adhikari, Talia N. Lerner,

Joel Finkelstein

и другие.

Nature, Год журнала: 2015, Номер 527(7577), С. 179 - 185

Опубликована: Ноя. 1, 2015

Язык: Английский

Процитировано

452

Fear Memory DOI Open Access
Iván Izquierdo, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw

и другие.

Physiological Reviews, Год журнала: 2016, Номер 96(2), С. 695 - 750

Опубликована: Март 17, 2016

Fear memory is the best-studied form of memory. It was thoroughly investigated in past 60 years mostly using two classical conditioning procedures (contextual fear and to a tone) one instrumental procedure (one-trial inhibitory avoidance). formed hippocampus avoidance), basolateral amygdala (inhibitory lateral (conditioning tone). The circuitry involves, addition, pre- infralimbic ventromedial prefrontal cortex, central subnuclei, dentate gyrus. learning models, notably avoidance, have also been very useful for analysis biochemical mechanisms consolidation as whole. These studies capitalized on vitro observations long-term potentiation other kinds plasticity. effect large number drugs has intensively studied, often prelude investigation effects anxiety. extinction involves an extent reversal flow information mentioned structures used therapy posttraumatic stress disorder memories general.

Язык: Английский

Процитировано

397

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man DOI
Robert J. Fenster, Lauren A. M. Lebois, Kerry J. Ressler

и другие.

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(9), С. 535 - 551

Опубликована: Июль 27, 2018

Язык: Английский

Процитировано

390

A Network Model of the Emotional Brain DOI
Luiz Pessoa

Trends in Cognitive Sciences, Год журнала: 2017, Номер 21(5), С. 357 - 371

Опубликована: Март 28, 2017

Язык: Английский

Процитировано

377

Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex DOI Creative Commons

Ada C. Felix‐Ortiz,

Anthony Burgos-Robles,

Neha D. Bhagat

и другие.

Neuroscience, Год журнала: 2015, Номер 321, С. 197 - 209

Опубликована: Июль 21, 2015

Highlights•BLA projections to the mPFC were targeted using optogenetic tools in mice.•Stimulation increased anxiety-like behavior and decreased social interaction.•Inhibition interaction.AbstractThe basolateral amygdala (BLA) medial prefrontal cortex (mPFC) modulate anxiety behaviors. It remains be elucidated, however, whether direct from BLA play a functional role these We used approaches behaving mice either activate or inhibit inputs during behavioral assays that assess interaction. Channelrhodopsin-2 (ChR2)-mediated activation of produced anxiogenic effects elevated plus maze open field test, whereas halorhodopsin (NpHR)-mediated inhibition anxiolytic effects. Furthermore, BLA-mPFC pathway reduced interaction resident-intruder facilitated These results establish causal relationship between activity bidirectional modulation anxiety-related

Язык: Английский

Процитировано

376

Stress and Fear Extinction DOI Open Access
Stephen Maren, Andrew Holmes

Neuropsychopharmacology, Год журнала: 2015, Номер 41(1), С. 58 - 79

Опубликована: Июнь 24, 2015

Язык: Английский

Процитировано

374

Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning DOI
Mark E. Bouton, Stephen Maren, Gavan P. McNally

и другие.

Physiological Reviews, Год журнала: 2020, Номер 101(2), С. 611 - 681

Опубликована: Сен. 24, 2020

This article reviews the behavioral neuroscience of extinction, phenomenon in which a behavior that has been acquired through Pavlovian or instrumental (operant) learning decreases strength when outcome reinforced it is removed. Behavioral research indicates neither nor operant extinction depends substantially on erasure original but instead new inhibitory primarily expressed context learned, as exemplified by renewal effect. Although nature inhibition may differ and either case decline responding depend both generalization decrement correction prediction error. At neural level, requires tripartite circuit involving amygdala, prefrontal cortex, hippocampus. Synaptic plasticity amygdala essential for learning, cortical neurons encoding fear memories involved retrieval. Hippocampal-prefrontal circuits mediate relapse phenomena, including renewal. Instrumental involves distinct ensembles corticostriatal, striatopallidal, striatohypothalamic well their thalamic returns (extinction) excitatory (renewal other phenomena) control over responding. The field made significant progress recent decades, although fully integrated biobehavioral understanding still awaits.

Язык: Английский

Процитировано

301

Rethinking Extinction DOI Creative Commons
Joseph E. Dunsmoor, Yael Niv, Nathaniel D. Daw

и другие.

Neuron, Год журнала: 2015, Номер 88(1), С. 47 - 63

Опубликована: Окт. 1, 2015

Язык: Английский

Процитировано

293

Fear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants DOI
Miquel À. Fullana, Anton Albajes‐Eizagirre, Carles Soriano‐Mas

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2018, Номер 88, С. 16 - 25

Опубликована: Март 11, 2018

Язык: Английский

Процитировано

267