Seminars in Cell and Developmental Biology, Год журнала: 2019, Номер 94, С. 59 - 65
Опубликована: Янв. 30, 2019
Язык: Английский
Nature Reviews Molecular Cell Biology, Год журнала: 2018, Номер 19(11), С. 713 - 730
Опубликована: Авг. 24, 2018
Язык: Английский
Процитировано
709
Nature reviews. Immunology, Год журнала: 2019, Номер 19(3), С. 154 - 169
Опубликована: Янв. 8, 2019
Язык: Английский
Процитировано
412
Redox Biology, Год журнала: 2020, Номер 36, С. 101678 - 101678
Опубликована: Авг. 7, 2020
Calcium (Ca2+) and reactive oxygen species (ROS) are versatile signaling molecules coordinating physiological pathophysiological processes. While channels pumps shuttle Ca2+ ions between extracellular space, cytosol cellular compartments, short-lived highly ROS constantly generated by various production sites within the cell. controls membrane potential, modulates mitochondrial adenosine triphosphate (ATP) affects proteins like calcineurin (CaN) or calmodulin (CaM), which, in turn, have a wide area of action. Overwhelming levels mitochondria efficiently induce trigger cell death. In contrast, comprise diverse group relatively unstable with an odd number electrons that abstract from other to gain stability. Depending on type produced amount, act either as affecting target harmful oxidative stressors damaging components. Due their range actions, it is little wonder pathways overlap impact one another. Growing evidence suggests crucial implication this mutual interplay development enhancement age-related disorders, including cardiovascular neurodegenerative diseases well cancer.
Язык: Английский
Процитировано
272
Physiological Reviews, Год журнала: 2021, Номер 102(2), С. 893 - 992
Опубликована: Окт. 26, 2021
The uptake of calcium into and extrusion from the mitochondrial matrix is a fundamental biological process that has critical effects on cellular metabolism, signaling, survival. Disruption (
Язык: Английский
Процитировано
242
Cell Calcium, Год журнала: 2017, Номер 63, С. 70 - 96
Опубликована: Янв. 18, 2017
Язык: Английский
Процитировано
197
Molecular Cell, Год журнала: 2020, Номер 78(6), С. 1055 - 1069
Опубликована: Июнь 1, 2020
Язык: Английский
Процитировано
187
Pharmacology & Therapeutics, Год журнала: 2018, Номер 192, С. 112 - 123
Опубликована: Июль 20, 2018
Язык: Английский
Процитировано
170
Frontiers in Cellular Neuroscience, Год журнала: 2021, Номер 15
Опубликована: Ноя. 17, 2021
Ischemic stroke refers to the disorder of blood supply local brain tissue caused by various reasons. It has high morbidity and mortality worldwide. Astrocytes are most abundant glial cells in central nervous system (CNS). They responsible for homeostasis, nutrition, protection CNS play an essential role many diseases’ physiological pathological processes. After injury, astrocytes activated a protective through heterogeneous gradual changes their gene expression, morphology, proliferation, function, that is, reactive astrocytes. However, position always been controversial topic. Many studies have shown double-edged sword with both beneficial harmful effects. is worth noting different spatial temporal expression determines astrocytes’ functions. Here, we comprehensively review roles mechanisms after ischemic stroke. In addition, intracellular mechanism astrocyte activation also involved. More importantly, due complex cascade reaction action stroke, still difficult define. Still, there no doubt one critical factors mediating deterioration or improvement
Язык: Английский
Процитировано
136
Cancer Research, Год журнала: 2022, Номер 82(12), С. 2254 - 2268
Опубликована: Апрель 12, 2022
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with few effective treatments. Here we show that the mitochondrial calcium uniporter (MCU) promotes PDAC cell migration, invasion, metastasis, and metabolic stress resistance by activating Keap1-Nrf2 antioxidant program. The cystine transporter SLC7A11 was identified as druggable target downstream of MCU-Nrf2 axis. Paradoxically, despite increased ability to uptake cystine, MCU-overexpressing demonstrated characteristics typical cystine-deprived cells were hypersensitive deprivation-induced ferroptosis. Pharmacologic inhibitors effectively induced tumor regression abrogated MCU-driven metastasis in PDAC. In patient-derived organoid models vitro xenograft vivo, MCU-high sensitivity inhibition compared MCU-low tumors. These data suggest MCU able promote drive cystine-dependent manner. MCU-mediated addiction could be exploited therapeutic vulnerability inhibit growth prevent metastasis.
Язык: Английский
Процитировано
76
Antioxidants, Год журнала: 2023, Номер 12(2), С. 353 - 353
Опубликована: Фев. 2, 2023
Mitochondria are key players in energy production, critical activity for the smooth functioning of energy-demanding organs such as muscles, brain, and heart. Therefore, dysregulation or alterations mitochondrial bioenergetics primarily perturb these organs. Within cell, mitochondria major site reactive oxygen species (ROS) production through different enzymes since it is one organelles with availability oxygen. ROS can act signaling molecules a number pathways by modulating calcium (Ca2+) signaling. Interactions among be considered bidirectional, regulating cellular Ca2+ signaling, whereas essential production. In particular, we will discuss how crosstalk between lead to dysfunctions consequent damage tissues at high demand, Changes induce associated reduced ATP increased ROS. These changes levels generation completely paralyze cardiac contractility. Thus, hinder excitation–contraction coupling, inducing arrhythmias, hypertrophy, apoptosis, necrosis cells. interplays cardiovascular system focus this review.
Язык: Английский
Процитировано
46