Seminars in Cell and Developmental Biology, Journal Year: 2019, Volume and Issue: 94, P. 59 - 65
Published: Jan. 30, 2019
Language: Английский
Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 19(11), P. 713 - 730
Published: Aug. 24, 2018
Language: Английский
Citations
709
Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(3), P. 154 - 169
Published: Jan. 8, 2019
Language: Английский
Citations
412
Redox Biology, Journal Year: 2020, Volume and Issue: 36, P. 101678 - 101678
Published: Aug. 7, 2020
Calcium (Ca2+) and reactive oxygen species (ROS) are versatile signaling molecules coordinating physiological pathophysiological processes. While channels pumps shuttle Ca2+ ions between extracellular space, cytosol cellular compartments, short-lived highly ROS constantly generated by various production sites within the cell. controls membrane potential, modulates mitochondrial adenosine triphosphate (ATP) affects proteins like calcineurin (CaN) or calmodulin (CaM), which, in turn, have a wide area of action. Overwhelming levels mitochondria efficiently induce trigger cell death. In contrast, comprise diverse group relatively unstable with an odd number electrons that abstract from other to gain stability. Depending on type produced amount, act either as affecting target harmful oxidative stressors damaging components. Due their range actions, it is little wonder pathways overlap impact one another. Growing evidence suggests crucial implication this mutual interplay development enhancement age-related disorders, including cardiovascular neurodegenerative diseases well cancer.
Language: Английский
Citations
272
Physiological Reviews, Journal Year: 2021, Volume and Issue: 102(2), P. 893 - 992
Published: Oct. 26, 2021
The uptake of calcium into and extrusion from the mitochondrial matrix is a fundamental biological process that has critical effects on cellular metabolism, signaling, survival. Disruption (
Language: Английский
Citations
242
Cell Calcium, Journal Year: 2017, Volume and Issue: 63, P. 70 - 96
Published: Jan. 18, 2017
Language: Английский
Citations
197
Molecular Cell, Journal Year: 2020, Volume and Issue: 78(6), P. 1055 - 1069
Published: June 1, 2020
Language: Английский
Citations
187
Pharmacology & Therapeutics, Journal Year: 2018, Volume and Issue: 192, P. 112 - 123
Published: July 20, 2018
Language: Английский
Citations
170
Frontiers in Cellular Neuroscience, Journal Year: 2021, Volume and Issue: 15
Published: Nov. 17, 2021
Ischemic stroke refers to the disorder of blood supply local brain tissue caused by various reasons. It has high morbidity and mortality worldwide. Astrocytes are most abundant glial cells in central nervous system (CNS). They responsible for homeostasis, nutrition, protection CNS play an essential role many diseases’ physiological pathological processes. After injury, astrocytes activated a protective through heterogeneous gradual changes their gene expression, morphology, proliferation, function, that is, reactive astrocytes. However, position always been controversial topic. Many studies have shown double-edged sword with both beneficial harmful effects. is worth noting different spatial temporal expression determines astrocytes’ functions. Here, we comprehensively review roles mechanisms after ischemic stroke. In addition, intracellular mechanism astrocyte activation also involved. More importantly, due complex cascade reaction action stroke, still difficult define. Still, there no doubt one critical factors mediating deterioration or improvement
Language: Английский
Citations
136
Cancer Research, Journal Year: 2022, Volume and Issue: 82(12), P. 2254 - 2268
Published: April 12, 2022
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with few effective treatments. Here we show that the mitochondrial calcium uniporter (MCU) promotes PDAC cell migration, invasion, metastasis, and metabolic stress resistance by activating Keap1-Nrf2 antioxidant program. The cystine transporter SLC7A11 was identified as druggable target downstream of MCU-Nrf2 axis. Paradoxically, despite increased ability to uptake cystine, MCU-overexpressing demonstrated characteristics typical cystine-deprived cells were hypersensitive deprivation-induced ferroptosis. Pharmacologic inhibitors effectively induced tumor regression abrogated MCU-driven metastasis in PDAC. In patient-derived organoid models vitro xenograft vivo, MCU-high sensitivity inhibition compared MCU-low tumors. These data suggest MCU able promote drive cystine-dependent manner. MCU-mediated addiction could be exploited therapeutic vulnerability inhibit growth prevent metastasis.
Language: Английский
Citations
76
Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 353 - 353
Published: Feb. 2, 2023
Mitochondria are key players in energy production, critical activity for the smooth functioning of energy-demanding organs such as muscles, brain, and heart. Therefore, dysregulation or alterations mitochondrial bioenergetics primarily perturb these organs. Within cell, mitochondria major site reactive oxygen species (ROS) production through different enzymes since it is one organelles with availability oxygen. ROS can act signaling molecules a number pathways by modulating calcium (Ca2+) signaling. Interactions among be considered bidirectional, regulating cellular Ca2+ signaling, whereas essential production. In particular, we will discuss how crosstalk between lead to dysfunctions consequent damage tissues at high demand, Changes induce associated reduced ATP increased ROS. These changes levels generation completely paralyze cardiac contractility. Thus, hinder excitation–contraction coupling, inducing arrhythmias, hypertrophy, apoptosis, necrosis cells. interplays cardiovascular system focus this review.
Language: Английский
Citations
46