Journal of Cell Science,
Год журнала:
2024,
Номер
137(9)
Опубликована: Май 1, 2024
ABSTRACT
Peroxisomes
are
highly
plastic
organelles
that
involved
in
several
metabolic
processes,
including
fatty
acid
oxidation,
ether
lipid
synthesis
and
redox
homeostasis.
Their
abundance
activity
dynamically
regulated
response
to
nutrient
availability
cellular
stress.
Damaged
or
superfluous
peroxisomes
removed
mainly
by
pexophagy,
the
selective
autophagy
of
induced
ubiquitylation
peroxisomal
membrane
proteins
ubiquitin-independent
processes.
Dysregulated
pexophagy
impairs
peroxisome
homeostasis
has
been
linked
development
various
human
diseases.
Despite
many
recent
insights
into
mammalian
our
understanding
this
process
is
still
limited
compared
yeast.
In
Cell
Science
at
a
Glance
article
accompanying
poster,
we
summarize
current
knowledge
on
control
highlight
which
aspects
require
further
attention.
We
also
discuss
role
describe
ubiquitin
machinery
regulating
signals
for
recruitment
phagophores
peroxisomes.
The Journal of Cell Biology,
Год журнала:
2024,
Номер
223(10)
Опубликована: Июль 5, 2024
Peroxisomes
are
membrane-bound
organelles
harboring
metabolic
enzymes.
In
humans,
peroxisomes
required
for
normal
development,
yet
the
genes
regulating
peroxisome
function
remain
unclear.
We
performed
a
genome-wide
CRISPRi
screen
to
identify
novel
factors
involved
in
peroxisomal
homeostasis.
found
that
inhibition
of
RNF146,
an
E3
ligase
activated
by
poly(ADP-ribose),
reduced
import
proteins
into
peroxisomes.
RNF146-mediated
loss
depended
on
stabilization
and
activity
poly(ADP-ribose)
polymerases
TNKS
TNKS2,
which
bind
membrane
protein
PEX14.
propose
RNF146
TNKS/2
regulate
efficiency
PARsylation
at
membrane.
Interestingly,
we
increased
RNF146-dependent
degradation
non-peroxisomal
substrates,
including
β-catenin
destruction
complex
component
AXIN1,
was
sufficient
alter
amplitude
transcription.
Together,
these
observations
not
only
suggest
previously
undescribed
roles
regulation
but
also
role
bridging
with
Wnt/β-catenin
signaling
during
development.
British Journal of Haematology,
Год журнала:
2024,
Номер
205(2), С. 429 - 439
Опубликована: Июнь 30, 2024
Summary
Erythroid
cells
undergo
a
highly
complex
maturation
process,
resulting
in
dynamic
changes
that
generate
red
blood
(RBCs)
rich
haemoglobin.
The
end
stages
of
the
erythroid
cell
process
primarily
include
chromatin
condensation
and
nuclear
polarization,
followed
by
expulsion
called
enucleation
clearance
mitochondria
other
organelles
to
finally
mature
RBCs.
While
healthy
RBCs
are
devoid
mitochondria,
recent
evidence
suggests
actively
implicated
processes
maturation,
erythroblast
RBC
production.
However,
extent
mitochondrial
participation
occurs
during
these
ultimate
steps
is
not
completely
understood.
This
specifically
important
since
abnormal
retention
or
DNA
contributes
pathophysiology
sickle
disorders.
Here
we
review
some
key
findings
so
far
elucidate
importance
this
various
aspects
production
under
homeostasis
disease
conditions.
Abstract
The
peroxisome
is
a
ubiquitous
organelle
in
rodent
cells
and
plays
important
roles
variety
of
cell
types
tissues.
It
previously
indicated
that
peroxisomes
are
associated
with
auditory
function,
patients
biogenesis
disorders
(PBDs)
found
to
have
hearing
dysfunction,
but
the
specific
role
remains
unclear.
In
this
study,
two
peroxisome‐deficient
mouse
models
(
Atoh1‐Pex5
−/−
Pax2‐Pex5
)
established
it
mainly
function
hair
cochleae.
Furthermore,
deficiency‐mediated
negative
effects
on
do
not
involve
mitochondrial
dysfunction
oxidative
damage.
Although
mammalian
target
rapamycin
complex
1
(mTORC1)
signaling
shown
through
peroxisomes,
no
changes
observed
mTORC1
−/‐
mice
when
compared
wild‐type
(WT)
mice.
However,
expression
large‐conductance,
voltage‐,
Ca2
+
‐activated
K
(BK)
channels
less
as
WT
mice,
administration
activators
BK
(NS‐1619
NS‐11021)
restores
knockout
These
results
suggest
play
an
essential
cochlear
by
regulating
channels.
Hence,
appear
probable
for
treating
peroxisome‐related
diseases
such
PBDs.
Acute
kidney
injury
(AKI)
is
a
systemic
clinical
syndrome
increasing
morbidity
and
mortality
worldwide
in
recent
years.
Renal
tubular
epithelial
cells
(TECs)
death
caused
by
mitochondrial
dysfunction
one
of
the
pathogeneses.
The
imbalance
quality
control
main
cause
dysfunction.
Mitochondrial
plays
crucial
role
AKI.
mechanisms
are
involved
regulating
integrity
function,
including
antioxidant
defense,
control,
DNA
(mtDNA)
repair,
dynamics,
mitophagy,
biogenesis.
Currently,
many
studies
have
used
as
targeted
therapeutic
strategy
for
Therefore,
this
review
aims
to
present
latest
research
advancements
on
AKI,
providing
valuable
reference
theoretical
foundation
prevention
treatment
condition,
ultimately
enhancing
patient
prognosis.
Journal of Cell Science,
Год журнала:
2024,
Номер
137(9)
Опубликована: Май 1, 2024
ABSTRACT
Peroxisomes
are
highly
plastic
organelles
that
involved
in
several
metabolic
processes,
including
fatty
acid
oxidation,
ether
lipid
synthesis
and
redox
homeostasis.
Their
abundance
activity
dynamically
regulated
response
to
nutrient
availability
cellular
stress.
Damaged
or
superfluous
peroxisomes
removed
mainly
by
pexophagy,
the
selective
autophagy
of
induced
ubiquitylation
peroxisomal
membrane
proteins
ubiquitin-independent
processes.
Dysregulated
pexophagy
impairs
peroxisome
homeostasis
has
been
linked
development
various
human
diseases.
Despite
many
recent
insights
into
mammalian
our
understanding
this
process
is
still
limited
compared
yeast.
In
Cell
Science
at
a
Glance
article
accompanying
poster,
we
summarize
current
knowledge
on
control
highlight
which
aspects
require
further
attention.
We
also
discuss
role
describe
ubiquitin
machinery
regulating
signals
for
recruitment
phagophores
peroxisomes.
