Aging, Год журнала: 2024, Номер unknown
Опубликована: Май 1, 2024
Dysregulation of the immune system and N
Язык: Английский
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Июнь 20, 2024
Abstract RNA methylation, a prevalent post-transcriptional modification, has garnered considerable attention in research circles. It exerts regulatory control over diverse biological functions by modulating splicing, translation, transport, and stability. Notably, studies have illuminated the substantial impact of methylation on tumor immunity. The primary types encompass N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N7-methylguanosine (m7G), 3-methylcytidine (m3C). Compelling evidence underscores involvement regulating microenvironment (TME). By affecting translation stability through "writers", "erasers" "readers", influence dysregulation immune cells factors. Consequently, plays pivotal role immunity mediating various behaviors, encompassing proliferation, invasion, metastasis, etc. In this review, we discussed mechanisms several methylations, providing comprehensive overview their roles underlying within among immunocytes. exploring how these modifications mediate evasion, also examine potential applications immunotherapy. This review aims to provide novel insights strategies for identifying targets advancing cancer immunotherapy efficacy.
Язык: Английский
Процитировано
35
The Lancet Oncology, Год журнала: 2024, Номер 25(8), С. e352 - e362
Опубликована: Июль 29, 2024
Язык: Английский
Процитировано
26
The EMBO Journal, Год журнала: 2023, Номер 42(15)
Опубликована: Июнь 22, 2023
Язык: Английский
Процитировано
29
Trends in Biochemical Sciences, Год журнала: 2024, Номер 49(7), С. 611 - 621
Опубликована: Апрель 26, 2024
Язык: Английский
Процитировано
14
MedComm, Год журнала: 2025, Номер 6(1)
Опубликована: Янв. 1, 2025
Abstract RNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such N6‐methyladenosine (m 6 A) 5‐methylcytosine 5 C), implicated in various cellular processes. These regulated by proteins write, erase, read modulate stability, splicing, translation, degradation. Recent studies have highlighted their roles metabolic reprogramming, signaling pathways, cell cycle control, which essential for tumor proliferation survival. Despite these scientific advances, the precise mechanisms affect remain inadequately understood. This review comprehensively examines role play proliferation, metastasis, programmed death, including apoptosis, autophagy, ferroptosis. It explores effects on epithelial–mesenchymal transition (EMT) immune microenvironment, particularly metastasis. Furthermore, modifications’ potential therapies, conventional treatments, immunotherapy, targeted is discussed. By addressing aspects, this aims to bridge current research gaps underscore therapeutic of targeting improve treatment strategies patient outcomes.
Язык: Английский
Процитировано
1
International Journal of Oncology, Год журнала: 2024, Номер 65(4)
Опубликована: Авг. 30, 2024
The use of antitumor drugs represents a reliable strategy for cancer therapy. Unfortunately, drug resistance has become increasingly common and contributes to tumor metastasis local recurrence. immune microenvironment (TME) consists cells, cytokines immunomodulators, collectively they influence the response treatment. Epigenetic changes including DNA methylation histone modification, as well increased exportation have been reported contribute development in cancers. In past few years, majority studies on tumors only focused progression from mechanistic standpoint; examined whether TME can also affect growth resistance. Recently, emerging evidence raised more concerns regarding role present review, it was discussed how suppressive adapts characterized by cooperation cytokines, stromal cells extracellular matrix. Furthermore, reviewed these immunological or metabolic alter immuno‑surveillance thus facilitate addition, potential targets developing novel therapeutic strategies improve individualized therapy treatment were revealed.
Язык: Английский
Процитировано
8
Cell, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
8
International Reviews of Immunology, Год журнала: 2024, Номер unknown, С. 1 - 16
Опубликована: Сен. 13, 2024
Inflammation induces tumor formation and plays a crucial role in progression prognosis. KCNK6, by regulating K(+) efflux to reduce NLRP3 Inflammasome-induced lung injury, relaxes the aorta. This study aims elucidate effects biological mechanism of KCNK6 inflammation-associated carcinogenesis, which may be essential for colon homeostasis defense system. To induce colitis, mice were given 3.0% Dextran Sodium Sulfate (DSS) their drinking water 7 days. The Azoxymethane (AOM) +DSS method was used cancer model. Bone marrow-derived macrophages (BMDM) from Kcnk6-/- mice, AW264.7 cells, human HCT116 Caco2 cells as
Язык: Английский
Процитировано
6
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 5, 2024
RNA methylation is an important regulatory process to determine immune cell function but how it affects the anti-tumor activity of CD8 T cells not fully understood. Here we show that N6-methyladenosine (m6A) reader YTHDF2 highly expressed in early effector or effector-like cells. We find facilitates nascent synthesis, and m6A recognition fundamental for this distinctively nuclear protein, which also reinforces its autoregulation at level. Loss exacerbates tumor progression confers unresponsiveness PD-1 blockade mice humans. In addition initiating decay necessary mitochondrial fitness, orchestrates chromatin changes promote polyfunctionality. interacts with IKZF1/3, sustained transcription their target genes. Accordingly, immunotherapy-induced efficacy could be largely restored YTHDF2-deficient through combinational use IKZF1/3 inhibitor lenalidomide a mouse model. Thus, coordinates epi-transcriptional transcriptional networks potentiate immunity, inform therapeutic intervention. has recently identified as mechanism governing functional cellular states, effect on antitumour + explored. authors assign essential nuclear, m6A-recognition-dependent YTHDF2, which, conjunction role IKZF1/3-mediated gene transcription, governs
Язык: Английский
Процитировано
6
Non-Coding RNA, Год журнала: 2024, Номер 10(1), С. 11 - 11
Опубликована: Фев. 5, 2024
Noncoding RNAs (ncRNAs), including circular (circRNAs) and N6-methyladenosine (m6A), have been shown to play a critical role in the development of various diseases obesity metabolic disorder-associated fatty liver disease (MAFLD). Obesity is chronic caused by excessive fat accumulation body, which has recently become more prevalent foremost risk factor for MAFLD. Causes may involve interaction genetic, behavioral, social factors. m6A RNA methylation might add novel inspiration understanding MAFLD with post-transcriptional regulation gene expression. In particular, circRNAs, microRNAs (miRNAs), be implicated progression Interestingly, modification can modulate translation, degradation, other functions ncRNAs. miRNAs/circRNAs also modifications affecting writers, erasers, readers. turn, ncRNAs could expression regulators different ways. However, there limited evidence on how these interact affect promotion diseases. It seems that occur DNA, RNA, proteins associated several biological properties. This study provides mechanistic association diseases, especially Comprehension between contribute treatment tactics
Язык: Английский
Процитировано
3