Circulation Research,
Год журнала:
2024,
Номер
134(6), С. 770 - 790
Опубликована: Март 14, 2024
Time-of-day
significantly
influences
the
severity
and
incidence
of
stroke.
Evidence
has
emerged
not
only
for
circadian
governance
over
stroke
risk
factors,
but
also
important
determinants
clinical
outcome.
In
this
review,
we
provide
a
comprehensive
overview
interplay
between
chronobiology
cerebrovascular
disease.
We
discuss
regulation
pathophysiological
mechanisms
underlying
onset
or
tolerance
as
well
in
vascular
dementia.
This
includes
cell
death
mechanisms,
metabolism,
mitochondrial
function,
inflammation/immunity.
Furthermore,
present
evidence
supporting
link
disrupted
rhythms
increased
susceptibility
to
propose
that
biochemical
physiological
pathways
brain
increase
damage
after
sleep
attenuate
treatment
effectiveness
during
active
phase.
review
underscores
importance
considering
biology
understanding
pathology
choice
dementia
speculates
patient's
chronotype
may
be
an
factor
developing
precision
following
Cells,
Год журнала:
2024,
Номер
13(10), С. 803 - 803
Опубликована: Май 8, 2024
Recent
evidence
indicates
that
exposure
to
environmental
toxins,
both
short-term
and
long-term,
can
increase
the
risk
of
developing
neurological
disorders,
including
neurodegenerative
diseases
(i.e.,
Alzheimer's
disease
other
dementias)
acute
brain
injury
stroke).
For
stroke,
latest
systematic
analysis
revealed
ambient
particulate
matter
is
second
most
frequent
stroke
after
high
blood
pressure.
However,
preclinical
clinical
investigations
on
deleterious
consequences
pollutants
are
scarce.
This
review
examines
recent
how
absorbed
along
digestive
tract
or
inhaled
through
lungs,
affect
host
cellular
response.
We
particularly
address
toxins
immune
response
microbiome
at
gut
lung
barrier
sites.
Additionally,
this
highlights
findings
showing
potential
contribution
an
increased
stroke.
A
better
understanding
biological
mechanisms
underlying
has
mitigate
disorders.
PLoS ONE,
Год журнала:
2024,
Номер
19(5), С. e0303213 - e0303213
Опубликована: Май 16, 2024
Ischemic
stroke
causes
a
lack
of
oxygen
and
glucose
supply
to
brain,
eventually
leads
severe
neurological
disorders.
Retinoic
acid
is
major
metabolic
product
vitamin
A
has
various
biological
effects.
The
PI3K-Akt
signaling
pathway
an
important
survival
in
brain.
Phosphorylated
Akt
regulating
apoptosis.
We
examined
whether
retinoic
neuroprotective
effects
model
by
its
downstream
protein,
Bad.
Moreover,
we
investigated
the
relationship
between
Bcl-2
family
protein
interactions.
Animals
were
intraperitoneally
administered
vehicle
or
(5
mg/kg)
for
four
days
before
surgery
ischemic
was
induced
middle
cerebral
artery
occlusion
(MCAO)
surgery.
Neurobehavioral
tests
performed
24
h
after
MCAO
cortical
tissues
collected.
Cresyl
violet
staining
TUNEL
histochemistry
performed,
Western
blot
immunoprecipitation
analysis
elucidate
expression
proteins.
reduced
deficits
histopathological
changes,
decreased
number
TUNEL-positive
cells,
alleviated
reduction
phospho-PDK1,
phospho-Akt,
phospho-Bad
caused
damage.
Immunoprecipitation
showed
that
damage
interaction
14-3-3,
which
attenuated
acid.
Furthermore,
mitigated
increase
Bcl-2/Bad
Bcl-xL/Bad
binding
levels
Bcl-2/Bax
Bcl-xL/Bax
MCAO-induced
caspase-3
cleaved
expression.
demonstrate
prevented
apoptosis
against
ischemia
through
phosphorylation
Bad,
maintenance
14-3-3
binding,
regulation
.
