BMC Nutrition, Год журнала: 2024, Номер 10(1)
Опубликована: Дек. 18, 2024
Язык: Английский
Nature Reviews Microbiology, Год журнала: 2024, Номер 22(11), С. 671 - 686
Опубликована: Июль 15, 2024
Язык: Английский
Процитировано
145
Molecular Systems Biology, Год журнала: 2024, Номер 20(6), С. 596 - 625
Опубликована: Май 14, 2024
Язык: Английский
Процитировано
26
Cell Host & Microbe, Год журнала: 2024, Номер 32(4), С. 527 - 542.e9
Опубликована: Март 20, 2024
Inflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and increasing in industrialized populations. Combined with host genetics, diet gut bacteria thought to contribute prominently IBDs, but mechanisms still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived microbiota promotes deterioration colonic mucus, leading lethal colitis. Inflammation starts expansion natural killer cells altered immunoglobulin-A coating some bacteria. Lethal colitis is then driven Th1 immune responses increased activities mucin-degrading cause first regions thinner mucus. A fiber-free exclusive enteral nutrition also induces mucus erosion inhibits simultaneously an anti-inflammatory bacterial metabolite, isobutyrate. Our findings underscore importance focusing on microbial functions—not taxa—contributing IBDs diet-mediated functions can oppose those promote disease.
Язык: Английский
Процитировано
25
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Март 13, 2024
Due to the physiological alteration during pregnancy, maternal gut microbiota changes following metabolic processes. Recent studies have revealed that is closely associated with immune microenvironment in utero pregnancy and plays a vital role specific complications, including preeclampsia, gestational diabetes, preterm birth recurrent miscarriages. Some other evidence has also shown aberrant increases risk of various diseases offspring, such as allergic neurodevelopmental disorders, through alignment between mother fetus possible intrauterine microbiota. Probiotics high-fiber diet are effective inventions prevent mothers fetuses from diseases. In this review, we summarize development complications health condition future generations perspective immunology, which may provide new therapeutic strategies for management offspring.
Язык: Английский
Процитировано
20
Nature Reviews Microbiology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 15, 2024
Язык: Английский
Процитировано
20
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3148 - 3148
Опубликована: Март 28, 2025
Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing
Язык: Английский
Процитировано
3
EMBO Molecular Medicine, Год журнала: 2023, Номер 15(8)
Опубликована: Июнь 6, 2023
Abstract In early life, the intestinal mucosa and immune system undergo a critical developmental process to contain expanding gut microbiome while promoting tolerance toward commensals, yet influence of maternal diet microbial composition on offspring maturation remains poorly understood. We colonized germ‐free mice with consortium 14 strains, fed them standard fiber‐rich chow or fiber‐free diet, then longitudinally assessed development during weaning period. Unlike pups born dams fiber‐deprived demonstrated delayed colonization Akkermansia muciniphila , mucin‐foraging bacterium that can also use milk oligosaccharides. The exhibited an enrichment colonic transcripts corresponding defense response pathways peak in Il22 expression at weaning. Removal A . from community, but maintenance was associated reduced proportions RORγt‐positive innate adaptive cell subsets. Our results highlight potent dietary fiber intake discrete changes postnatal assemblage development.
Язык: Английский
Процитировано
27
Nature Microbiology, Год журнала: 2024, Номер 9(9), С. 2244 - 2261
Опубликована: Июль 15, 2024
Gut bacteria are linked to neurodegenerative diseases but the risk factors beyond microbiota composition limited. Here we used a pre-clinical model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), identify microbial factors. Mice with different genotypes and complex microbiotas or six combinations synthetic human were analysed, resulting in varying probabilities severe neuroinflammation. However, presence relative abundances suspected failed predict disease severity. Akkermansia muciniphila, often associated MS, exhibited variable associations EAE severity depending on background microbiota. Significant inter-individual course variations observed among mice harbouring same Evaluation functional characteristics host immune responses demonstrated that immunoglobulin A coating index certain before onset is robust individualized predictor development. Our study highlights need consider community networks host-specific bidirectional interactions when aiming
Язык: Английский
Процитировано
15
FEBS Journal, Год журнала: 2024, Номер unknown
Опубликована: Март 24, 2024
The intestinal microbiota has major influence on human physiology and modulates health disease. Complex host–microbe interactions regulate various homeostatic processes, including metabolism immune function, while disturbances in composition (dysbiosis) are associated with a plethora of diseases believed to modulate disease initiation, progression therapy response. vast complexity the its metabolic output represents great challenge unraveling molecular basis specific physiological contexts. To increase our understanding these interactions, functional research using animal models reductionistic setting essential. In dynamic landscape gut research, use germ‐free gnotobiotic mouse technology, which causal disease‐driving mechanisms can be dissected, pivotal investigative tool for disease, dissected. A better health‐modulating functions opens perspectives improved therapies many diseases. this review, we discuss practical considerations design execution experiments, around rederivation housing conditions, route timing microbial administration, dosing protocols. This comprehensive overview aims provide researchers valuable insights experimental field research.
Язык: Английский
Процитировано
11
Seminars in Immunology, Год журнала: 2024, Номер 73, С. 101885 - 101885
Опубликована: Май 1, 2024
The gut microbiota is well known to possess immunomodulatory capacities, influencing a multitude of cellular signalling pathways maintain host homeostasis. Although the formation immune system initiates before birth in sterile environment, an emerging body literature indicates that neonatal influenced by first wave external stimuli includes signals from maternal microbiota. A second stimulus begins after and must be tightly regulated during period when colonization occurs concomitantly with maturation system, requiring fine adjustment between establishing tolerance towards commensal preserving inflammatory responses against pathogenic invaders. Besides integrating cues microbes, also regulate triggered other environmental signals, such as dietary antigens, which become more complex introduction solid food weaning period. This "window opportunity" early life thought crucial for proper development setting tone subsequent adulthood modulating risk developing chronic metabolic diseases. Here we review importance host-microbiota interactions particularly early-life period, highlighting mechanisms involved communication. discussion focused on recent data demonstrating microbiota-mediated education innate cells its role lymphoid tissues.
Язык: Английский
Процитировано
10