Maternal dietary habit influences fetal life DOI Creative Commons
Ruby Dhar, Arun Kumar, Subhradip Karmakar

et al.

Asian Journal of Medical Sciences, Journal Year: 2023, Volume and Issue: 14(11), P. 1 - 2

Published: Nov. 1, 2023

Diet and nutrition have a tremendous influence on health disease. Dietary constituents can affect been known to supplement with essential nutrients, minerals, calories for physiological homeostasis. However, diet also gene expression through epigenetic reprogramming or by altering the level of micronutrients. While nutrigenomics study has delineated this causal link, recent published in EMBO Molecular Medicine Grant et al. went step further establish that maternal intake dietary fibers alter fetal gut microbiome, influencing diversity intestinal bacterial flora, thereby affecting gut-brain axis. Although relationship between fertility males females reported, effect postnatal life is not well documented. In at (Luxembourg Institute Health, Esch-sur-Alzette, Luxembourg), authors reported selected feeding fiber-free diets pregnant mice alters microbiome composition their neonate pups depriving them protective beneficial commensal, Akkermansia muciniphila, mucin-foraging bacterium. Further, these animals exhibited heightened immune activity enriching defense response pathways IL-22 expression. Therefore, role A. muciniphila associated its protection against chronic inflammation TLR4 signaling. The author’s far-reaching conclusions improving human outcomes rational choice food, drugs, lifestyle prevent dysbiosis colonization right microbiome.

Language: Английский

The interplay between diet and the gut microbiome: implications for health and disease DOI
Fiona C. Ross, Dhrati Patangia, Ghjuvan Micaelu Grimaud

et al.

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(11), P. 671 - 686

Published: July 15, 2024

Language: Английский

Citations

112
Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host DOI Creative Commons
Gabriel Vasconcelos Pereira, Marie Boudaud, Mathis Wolter

et al.

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(4), P. 527 - 542.e9

Published: March 20, 2024

Inflammatory bowel diseases (IBDs) are chronic conditions characterized by periods of spontaneous intestinal inflammation and increasing in industrialized populations. Combined with host genetics, diet gut bacteria thought to contribute prominently IBDs, but mechanisms still emerging. In mice lacking the IBD-associated cytokine, interleukin-10, we show that a fiber-deprived microbiota promotes deterioration colonic mucus, leading lethal colitis. Inflammation starts expansion natural killer cells altered immunoglobulin-A coating some bacteria. Lethal colitis is then driven Th1 immune responses increased activities mucin-degrading cause first regions thinner mucus. A fiber-free exclusive enteral nutrition also induces mucus erosion inhibits simultaneously an anti-inflammatory bacterial metabolite, isobutyrate. Our findings underscore importance focusing on microbial functions—not taxa—contributing IBDs diet-mediated functions can oppose those promote disease.

Language: Английский

Citations

22
Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility DOI

Mathis Wolter,

Erica T. Grant, Marie Boudaud

et al.

Molecular Systems Biology, Journal Year: 2024, Volume and Issue: 20(6), P. 596 - 625

Published: May 14, 2024

Language: Английский

Citations

21
Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology DOI Creative Commons

Xiaowen Lu,

Zhan Shi, Lingling Jiang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 13, 2024

Due to the physiological alteration during pregnancy, maternal gut microbiota changes following metabolic processes. Recent studies have revealed that is closely associated with immune microenvironment in utero pregnancy and plays a vital role specific complications, including preeclampsia, gestational diabetes, preterm birth recurrent miscarriages. Some other evidence has also shown aberrant increases risk of various diseases offspring, such as allergic neurodevelopmental disorders, through alignment between mother fetus possible intrauterine microbiota. Probiotics high-fiber diet are effective inventions prevent mothers fetuses from diseases. In this review, we summarize development complications health condition future generations perspective immunology, which may provide new therapeutic strategies for management offspring.

Language: Английский

Citations

17
Maternal diet and gut microbiome composition modulate early‐life immune development DOI Creative Commons
Erica T. Grant, Marie Boudaud, Arnaud Muller

et al.

EMBO Molecular Medicine, Journal Year: 2023, Volume and Issue: 15(8)

Published: June 6, 2023

Abstract In early life, the intestinal mucosa and immune system undergo a critical developmental process to contain expanding gut microbiome while promoting tolerance toward commensals, yet influence of maternal diet microbial composition on offspring maturation remains poorly understood. We colonized germ‐free mice with consortium 14 strains, fed them standard fiber‐rich chow or fiber‐free diet, then longitudinally assessed development during weaning period. Unlike pups born dams fiber‐deprived demonstrated delayed colonization Akkermansia muciniphila , mucin‐foraging bacterium that can also use milk oligosaccharides. The exhibited an enrichment colonic transcripts corresponding defense response pathways peak in Il22 expression at weaning. Removal A . from community, but maintenance was associated reduced proportions RORγt‐positive innate adaptive cell subsets. Our results highlight potent dietary fiber intake discrete changes postnatal assemblage development.

Language: Английский

Citations

26
Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential DOI
Athanasia Ioannou, Maryse D Berkhout,

Sharon Y. Geerlings

et al.

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Language: Английский

Citations

16
A guide to germ‐free and gnotobiotic mouse technology to study health and disease DOI Open Access
Maude Jans, Lars Vereecke

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: March 24, 2024

The intestinal microbiota has major influence on human physiology and modulates health disease. Complex host–microbe interactions regulate various homeostatic processes, including metabolism immune function, while disturbances in composition (dysbiosis) are associated with a plethora of diseases believed to modulate disease initiation, progression therapy response. vast complexity the its metabolic output represents great challenge unraveling molecular basis specific physiological contexts. To increase our understanding these interactions, functional research using animal models reductionistic setting essential. In dynamic landscape gut research, use germ‐free gnotobiotic mouse technology, which causal disease‐driving mechanisms can be dissected, pivotal investigative tool for disease, dissected. A better health‐modulating functions opens perspectives improved therapies many diseases. this review, we discuss practical considerations design execution experiments, around rederivation housing conditions, route timing microbial administration, dosing protocols. This comprehensive overview aims provide researchers valuable insights experimental field research.

Language: Английский

Citations

11
Gut microbial factors predict disease severity in a mouse model of multiple sclerosis DOI Creative Commons
Alex Steimle, Mareike Neumann, Erica T. Grant

et al.

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(9), P. 2244 - 2261

Published: July 15, 2024

Gut bacteria are linked to neurodegenerative diseases but the risk factors beyond microbiota composition limited. Here we used a pre-clinical model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), identify microbial factors. Mice with different genotypes and complex microbiotas or six combinations synthetic human were analysed, resulting in varying probabilities severe neuroinflammation. However, presence relative abundances suspected failed predict disease severity. Akkermansia muciniphila, often associated MS, exhibited variable associations EAE severity depending on background microbiota. Significant inter-individual course variations observed among mice harbouring same Evaluation functional characteristics host immune responses demonstrated that immunoglobulin A coating index certain before onset is robust individualized predictor development. Our study highlights need consider community networks host-specific bidirectional interactions when aiming

Language: Английский

Citations

11
Early life microbiome influences on development of the mucosal innate immune system DOI Creative Commons

Aline Ignácio,

Sonia Czyz,

Kathy D. McCoy

et al.

Seminars in Immunology, Journal Year: 2024, Volume and Issue: 73, P. 101885 - 101885

Published: May 1, 2024

The gut microbiota is well known to possess immunomodulatory capacities, influencing a multitude of cellular signalling pathways maintain host homeostasis. Although the formation immune system initiates before birth in sterile environment, an emerging body literature indicates that neonatal influenced by first wave external stimuli includes signals from maternal microbiota. A second stimulus begins after and must be tightly regulated during period when colonization occurs concomitantly with maturation system, requiring fine adjustment between establishing tolerance towards commensal preserving inflammatory responses against pathogenic invaders. Besides integrating cues microbes, also regulate triggered other environmental signals, such as dietary antigens, which become more complex introduction solid food weaning period. This "window opportunity" early life thought crucial for proper development setting tone subsequent adulthood modulating risk developing chronic metabolic diseases. Here we review importance host-microbiota interactions particularly early-life period, highlighting mechanisms involved communication. discussion focused on recent data demonstrating microbiota-mediated education innate cells its role lymphoid tissues.

Language: Английский

Citations

9
Higher gut Bacteroidetes and Actinobacteria population in early pregnancy is associated with lower risk of gestational diabetes in the second trimester DOI Creative Commons

Seyedeh Neda Mousavi,

Navid Momeni,

Hossein Chiti

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 3, 2025

Despite the association between gut dysbiosis and metabolic disorders, main bacterial phylum in first trimester of pregnancy that predisposes mothers to gestational diabetes mellitus (GDM) second is not clear around world. Three-hundred healthy women aged 18-40 years who were participated this cohort study followed screening time for GDM diagnosis (in 24-28 weeks pregnancy). Stool samples gathered trimester. was diagnosed based on International Association Diabetes Pregnancy Groups. In total, thirty with GDM. Controls (N = 60) selected from non-GDM participants matching terms pre-pregnancy weight, weight gain, dietary intake familial history diabetes. The dominant population determined 16SrRNA gene expression. Mothers lower Bacteroidetes Actinobacteria more susceptible (p < 0.001 p 0.001). Firmicutes ratio significantly higher than controls A significant negative correlation observed 0.001, 0.001) 0.004, 0.02) serum FBS, 1 h-PG 2 levels time. However, 0.003, 0.01) showed a positive FBS levels. at associated risk Higher fasting 1-h glucose intolerance

Language: Английский

Citations

1