South Russian Journal of Therapeutic Practice,
Год журнала:
2023,
Номер
4(2), С. 35 - 45
Опубликована: Июль 4, 2023
Ischemic
stroke
(IS)
remains
the
most
common
neurological
pathology
[1,2]
and
can
manifest
itself
in
form
of
malignant
ischemic
(MIS),
leading
not
only
to
severe
disability
patient,
but
life-threatening
conditions
[3,4].
Malignant
is
one
formidable
manifestations
stroke,
threatening
working
population
likelihood
death
without
appointment
timely
therapy.
Diagnosis:“Malignant
stroke”
occur
no
earlier
than
12-24
hours,
during
which
time
irreversible
changes
brain
may
occur,
accompanied
by
its
pronounced
edema,
with
threat
subsequent
herniation,
therefore,
adequate
therapy
necessary
as
soon
possible
[5,6]
.
Taking
into
account
peculiarities
course
disease,
there
a
need
search
for
predictors
MIS.
In
order
predict
consequences,
above
literature
review,
we
consider
modern
approaches
diagnosing
stroke.
The
analysis
data
allows
us
determine
some
clinical
laboratory
development
methods
assessing
severity
Various
possibilities
using
studied
markers
purpose
practical
use
early
diagnosis
MIS
are
considered.
Based
on
data,
diagnostics
were
analyzed
prescribe
before
onset
brain.
Meditsinskiy sovet = Medical Council,
Год журнала:
2024,
Номер
13, С. 34 - 44
Опубликована: Сен. 1, 2024
Chronic
hypertension
(CH)
complicates
the
course
of
pregnancy
in
1-2%
cases,
and
it
is
increasingly
common.
Compared
with
normotensive
women,
women
CH
have
a
high
risk
maternal
perinatal
complications.
Antihypertensive
treatment
halves
severe
but
does
not
reduce
incidence
preeclampsia
or
serious
complications,
which
may
be
due
to
small
number
observations
studies
conducted.
In
addition,
affect
mortality
morbidity
fetus
and/or
newborn,
regardless
start
date
antihypertensive
therapy.
Traditionally
used
drugs
been
proven
teratogenic,
while
there
an
increase
frequency
congenital
malformations
associated
primarily
uncontrolled
chronic
hypertension.
Although
prescribing
approved
agents
for
all
during
are
effective
lowering
blood
pressure
most
remains
unclear
whether
optimal
drug
monotherapy
combinations
best
used.
An
alternative
approach
individualize
using
characteristics
characteristics,
addition
levels
(for
example,
variability),
also
prognostic
value.
This
review
examines
current
data
on
pregnant
from
perspective
national
international
recommendations.
Discussion
existing
unresolved
issues
can
serve
as
basis
personalized
management
CH.
PULMONOLOGIYA,
Год журнала:
2022,
Номер
32(5), С. 651 - 660
Опубликована: Сен. 21, 2022
According
to
the
World
Health
Organization
(WHO),
bronchial
asthma
(BA)
is
a
major
non-communicable
disease
which
affects
both
adults
and
children
thereby
impacts
economy.
The
aim
.
To
analyze
morbidity
follow-up
care
in
Russia
2019
as
compared
with
2014.
Methods
official
statistical
data
of
Ministry
Federal
State
Statistics
Service
(Rosstat)
on
BA
was
used.
defined
class
X
J45
–
J46
(asthma,
asthmatic
status)
according
International
Classification
Diseases
Health-Related
Problems,
10th
revision
1
989
(ICD-10).
Results
961.6
2014
1085.0
(+11.4%;
p
<
0,001)
per
100
thousand
total
population
(1,592,596
people).
accounted
for
2.7%
all
respiratory
diseases
(RD)
morbidity.
were
higher
than
average
4
federal
districts
(FD)
maximum
rate
Siberian
FD
(1,185.5
1,507.1
population,
respectively).
In
2019,
decreased
among
aged
0
14
years,
did
not
change
15
17
years
increased
adults.
highest
rates
registered
North-Western
(2,943.7
corresponding
age
group).
87.1%
patients
received
care.
32.3%
people
(944.3
population)
under
number
recorded
(1,328.3
population),
lowest
North
Caucasian
(288.3).
Conclusion
There
an
increase
from
numbers
reported
adolescents
FD.
quality
medical
correlated
high
coverage
Pharmacy & Pharmacology,
Год журнала:
2022,
Номер
10(5), С. 404 - 415
Опубликована: Дек. 11, 2022
The
aim
of
the
work
was
to
carry
out
a
systematic
analysis
molecular
mechanisms
that
determine
possibility
combined
use
amino
acid
glycine
and
zinc
compounds
for
treatment
patients
with
manifestations
stress
anxiety.
Materials
methods.
Information
retrieval
(Scopus,
PubMed)
library
(eLibrary)
databases
were
used
as
research
tools.
In
some
cases,
ResearchGate
application
applied
semantic
search.
generalization
references
carried
on
topic,
covering
period
from
2000
present
time.
Results.
It
has
been
shown
glycine,
along
gamma-aminobutyric
(GABA),
is
key
neurotransmitter
regulates
physiological
inhibition
processes
in
central
nervous
system
(CNS)
by
increasing
transmembrane
conductance
specific
pentameric
ligand-gated
ion
channels.
introduction
ions
can
potentiate
opening
these
receptors
their
affinity
resulting
an
inhibitory
increase
CNS
neurons.
replenishment
deficiency
important
element
correction
post-stress
dysfunction
system.
A
balanced
intake
essential
most
people
who
experience
daily
effects
multiple
stresses
This
combination
especially
useful
experiencing
state
chronic
psycho-emotional
maladaptation,
including
those
have
difficulty
falling
asleep.
Conclusion.
maintenance
concentration
body
healthy
person
leads
development
stable
anti-anxiety
effect,
which
accompanied
normalization
sleep-wake
rhythm,
makes
it
possible
good
rest
without
any
loss
working
efficiency
after
waking
up.
Meditsinskiy sovet = Medical Council,
Год журнала:
2023,
Номер
6, С. 76 - 82
Опубликована: Май 4, 2023
Psycho-emotional
disorders,
such
as
anxiety
acute
and
chronic
stress,
are
significant
risk
factors
for
the
development
complicated
course
of
both
major
cardiovascular
other
common
non-communicable
diseases.
The
psycho-emotional
disorders
significantly
reduce
patients’
motivation
adherence
to
lifestyle
changes
drug
therapy,
worse
quality
life,
increase
disability
healthcare
system
expenditures.
topicality
issues
diagnosis
management
in
general
practitioner’s
practice
is
caused,
on
one
hand,
by
high
rates
these
patients
with
diseases,
deterioration
life
an
adverse
outcomes,
inadequate
awareness
risks
associated
sphere
status
patients.
includes
pharmacological
non-pharmacological
treatments.
Antidepressants
that
fall
into
class
selective
serotonin
or
norepinephrine
reuptake
inhibitors
first-line
drugs
used
treatment
most
discussed.
However,
prescription
requires
take
account
a
wide
range
possible
side
effects
including
CVDs.
Drugs
have
fast
onsets
sedative
anti-anxiety
action,
also
known
tranquilizers,
more
widely
real-world
clinical
practice.
Tofisopam
promising
from
this
group
therapeutic
cardiological
efficacy
safety
tofisopam
been
studied
numerous
studies
diseases
long-term
use
drug.
Terapevticheskii arkhiv,
Год журнала:
2023,
Номер
95(8), С. 710 - 715
Опубликована: Окт. 11, 2023
Anxiety
and
anxiety
disorders
are
important
modifiable
risk
factors
for
cardiovascular
other
common
chronic
non-communicable
diseases
complications.
significantly
reduce
the
motivation
adherence
of
patients
to
lifestyle
changes
drug
therapy,
worsen
quality
life,
increase
disability
costs
health
care
system.
The
issues
diagnosis
therapy
relevant
practice
physicians
cardiologists
due
high
incidence
in
with
diseases,
a
decrease
life
an
adverse
outcomes,
also
insufficient
awareness
risks
associated
psycho-emotional
state
patients.
Therapy
includes
both
non-drug
methods.
first-line
drugs
treating
most
selective
serotonin
reuptake
inhibitors
or
serotonin-norepinephrine
inhibitors.
possible
side
effects
these
agents
should
be
considered.
Sedative
anti-anxiety
drugs,
including
non-benzodiazepine
tranquilizers,
more
commonly
used.
studied
from
this
class
therapeutic
cardiological
is
fabomotizole.
efficacy
safety
fabomotizole,
long-term
use,
have
been
numerous
studies
wide
range
disorders.
Bulletin of Science and Practice,
Год журнала:
2024,
Номер
10(4), С. 268 - 303
Опубликована: Апрель 15, 2024
The
review
article
examines
the
issues
of
obesity
regarding
its
prevalence,
phenotypes,
course
and
consequences.
anatomical,
physiological
functional
features
adipose
tissue
are
discussed.
“Discussion”
section
presents
authors’
own
clinical
observations
on
therapeutic
surgical
in
treatment
obesity.
Currently,
is
divided
into
white,
brown
beige.
White
can
turn
each
other
through
beige
stage.
volume
activity
require
greater
expenditure
metabolism
oxygen
molecules
more
pronounced
women.
components
extracellular
matrix
collagen
types
I,
III,
V,
VI.
structure
varies
depending
location,
size
fat,
age,
gender,
state
kidneys,
thyroid
gland,
nature
food,
energy
sleep
patterns.
With
intense
work
cold
exposure,
hormone
irisin
formed
skeletal
muscles,
which
promotes
transformation
white
or
beige,
helps
reduce
body
weight
obesity,
has
a
beneficial
effect
type
2
diabetes
mellitus
associated
diseases.
Traditionally,
obese
individuals
metabolically
healthy
unhealthy
based
degree
metabolic
disorders.
In
visceral
lipolysis
occurs
with
high
intensity,
supports
development
inflammation.
decreased
expression
adiponectin
accelerates
atherosclerotic
cardiovascular
As
increases,
acquires
an
inflammatory
phenotype,
manifested
by
increased
cytokines
(interleukin-6,
interleukin-1,
interleukin-17,
tumor
necrosis
factor-alpha),
hyperactivation
renin-angiotensin-aldosterone
system,
as
well
excessive
cell
infiltration
immune
system
(leukocytes,
neutrophils,
T-lymphocytes,
monocytes,
macrophages).
During
inflammation
tissue,
(M1)
atherogenic
(M4)
phenotypes
macrophages
dominate.
morbid
number
reach
up
to
50%
all
cells.
Healthcare,
Год журнала:
2024,
Номер
12(19), С. 2004 - 2004
Опубликована: Окт. 7, 2024
In
modern
medicine,
studies
devoted
to
the
assessment
of
parameters
residential
infrastructure
and
population’s
attitude
towards
them
have
become
quite
large-scale.
Objectives:
The
aim
study
was
establish
associations
between
individually
perceived
main
modifiable
cardiovascular
risk
factors
(hypertension,
obesity,
lipid
carbohydrate
metabolism
disorders)
in
one
subjects
Russian
Federation.
Methods:
epidemiological
“Study
influence
social
on
chronic
non-communicable
diseases”
started
2015
ended
2023.
sample
formed
by
using
stratification
method
based
assignment
a
medical
organization.
included
1598
respondents
aged
35
70
years
(491
rural
residents).
conducted
subjective
opinions
neighborhood
environment
walkability
scale
(NEWS)
questionnaire,
divided
into
eight
scales.
Logistic
regression
analysis
used
identify
factors;
odds
ratio
(OR)
95%
confidence
interval
were
evaluated.
Results:
Individually
B,
reflecting
accessibility
facilities,
associated
with
hypertension
[OR
=
1.33],
obesity
1.40],
abdominal
1.59].
Elements
C,
describing
streets
area,
increased
likelihood
developing
1.42]
visceral
1.43].
characteristics
represented
D
that
evaluates
pedestrian
infrastructure,
all
major
(hypertension
1.65],
1.62]
1.82],
disorders
1.41]
1.44]).
Conclusion:
Social
various
aspects
important
criteria
for
determining
health.
Environmental
conditions
affect
through
behavioral
patterns
shape
respondent’s
lifestyle.
Interventions
urban
planning—increasing
facilities
population,
pedestrian-friendly
environment,
improving
physical
activity
resources
areas,
planning
recreation
landscaping—can
most
concept
prevention
diseases.
