npj Regenerative Medicine,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 17, 2022
Peritubular
capillaries
(PTCs)
are
closely
related
to
renal
tubules
in
structure
and
function,
both
pivotal
regulators
the
development
progression
of
acute
kidney
injury
(AKI).
However,
mechanisms
that
underlie
interaction
between
PTCs
during
AKI
remain
unclear.
Here
we
explored
a
new
mode
tubulovascular
crosstalk
mediated
by
small
extracellular
vesicles
(sEV)
after
AKI.
In
response
ischemia/reperfusion
(I/R)
injury,
endothelial
proliferation
tubular
expression
vascular
growth
factor-A
(VEGF-A)
were
increased,
accompanied
remarkable
redistribution
cytoplasmic
VEGF-A
basolateral
side
cells.
Meanwhile,
secretion
was
converted
injured
cells,
which
showed
much
greater
tendency
secrete
via
sEV
other
than
free
form.
Interestingly,
cell-derived
VEGF-A-enriched
(sEV-VEGF-A)
turned
out
promote
regulated
VEGF
receptors
1
2.
Furthermore,
inhibition
Rab27a
knockdown
resulted
significant
decrease
peritubular
cells
vivo.
Importantly,
taking
advantage
newly
recognized
endogenous
repair
PTCs,
exogenous
supplementation
+
efficiently
recused
PTC
rarefaction,
improved
perfusion,
halted
CKD
transition.
Taken
together,
our
study
uncovered
novel
intrinsic
through
tubule-PTC
sEV-VEGF-A,
could
be
exploited
as
promising
therapeutic
angiogenesis
strategy
diseases
with
ischemia.
Journal of the American Society of Nephrology,
Год журнала:
2024,
Номер
35(6), С. 795 - 808
Опубликована: Фев. 14, 2024
Kidney
injury
molecule-1
(KIM-1),
also
known
as
T-cell
Ig
and
mucin
domain-1
(TIM-1),
is
a
widely
recognized
biomarker
for
AKI,
but
its
biological
function
less
appreciated.
KIM-1/TIM-1
belongs
to
the
domain
family
of
conserved
transmembrane
proteins,
which
bear
characteristic
six-cysteine
Ig-like
variable
domain.
The
latter
enables
binding
natural
ligand,
phosphatidylserine,
expressed
on
surface
apoptotic
cells
necrotic
cells.
in
variety
tissues
plays
fundamental
roles
regulating
sterile
inflammation
adaptive
immune
responses.
In
kidney,
KIM-1
upregulated
injured
renal
proximal
tubule
cells,
transforms
them
into
phagocytes
clearance
dying
helps
dampen
inflammation.
TIM-1,
T
B
killer
essential
cell
activation
regulatory
functions
host.
Functional
polymorphisms
gene
KIM-1/TIM-1,
HAVCR1
,
have
been
associated
with
susceptibility
immunoinflammatory
conditions
hepatitis
A
virus-induced
liver
failure,
thought
be
due
differential
ability
variants
bind
phosphatidylserine.
This
review
will
summarize
role
health
disease
potential
clinical
applications
therapeutic
target
humans.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101534 - 101534
Опубликована: Янв. 29, 2025
The
treatment
and
management
of
kidney
diseases
pose
a
significant
global
burden.
Due
to
the
presence
blood
circulation
barriers
glomerular
filtration
barriers,
drug
therapy
for
faces
challenges
such
as
poor
renal
targeting,
short
half-life,
severe
systemic
side
effects,
severely
hindering
therapeutic
progress.
Therefore,
research
development
kidney-targeted
agents
is
great
clinical
significance.
In
recent
years,
application
nanotechnology
in
field
nephrology
has
shown
potential
revolutionizing
diagnosis
diseases.
Carefully
designed
nanomaterials
can
exhibit
optimal
biological
characteristics,
influencing
various
aspects
circulation,
retention,
excretion.
Rationally
designing
modifying
based
on
anatomical
structure
pathophysiological
environment
achieve
highly
specific
or
nanodrug
delivery
systems
both
feasible
promising.
Based
targeted
diseases,
this
review
discusses
advantages
limitations
current
nanomedicine
summarizes
active/passive
targeting
strategies,
order
further
promote
through
preliminary
summary
previous
studies
future
prospects.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 27, 2025
Chronic
kidney
disease
(CKD)
ultimately
causes
renal
fibrosis
and
end-stage
disease,
thus
seriously
threatens
human
health.
However,
current
medications
for
CKD
are
inefficient,
which
is
often
due
to
poor
targeting
capability
tubule.
In
this
study,
we
discover
that
biomimetic
high-density
lipoprotein
(bHDL)
lipid
nanoparticles
possess
excellent
ability
injured
tubular
epithelial
cells
by
injury
molecule-1(KIM-1)
mediated
internalization.
Thus,
co-load
anti-inflammatory
drug
triptolide
(TP)
anti-fibrotic
nintedanib
(BIBF)
on
bHDL
treat
CKD.
Based
the
targeted
delivery
mutual
enhancement
of
efficacy
co-delivered
drugs,
bHDL-based
system
effectively
reduces
alleviates
in
different
mouse
models.
The
mechanistic
study
shows
BIBF
TP
synergistically
remodel
fibrotic
niches
decreasing
inflammatory
cytokines,
limiting
immune
cell
infiltration
inhibiting
activation
myofibroblasts.
vehicle
also
possesses
high
manufacturability,
good
safety
adequately
toxicity
TP.
promising
treatment
has
potential
delivering
agents
damaged
cells.
Effectively
tubule
delay
or
halt
chronic
progression
remains
a
significant
unmet
clinical
challenge.
Here,
authors
introduce
an
innovative
strategy
using
nanoparticles.
PLoS ONE,
Год журнала:
2025,
Номер
20(1), С. e0311755 - e0311755
Опубликована: Янв. 29, 2025
Acute
kidney
injury
(AKI)
is
a
frequent
clinical
complication
lacking
early
diagnostic
tests
and
effective
treatments.
Novel
biomarkers
have
shown
promise
for
enabling
earlier
detection,
risk
stratification,
guiding
management
of
AKI.
We
conducted
systematic
review
to
synthesize
evidence
on
the
efficacy
novel
AKI
detection
management.
Database
searches
yielded
17
relevant
studies
which
were
critically
appraised.
Key
themes
biomarker
in
predicting
severity
before
functional
changes;
potential
improve
through
diagnosis,
prognostic
enrichment,
interventions;
emerging
roles
as
therapeutic
targets
tools;
ongoing
challenges
requiring
further
validation.
Overall,
like
neutrophil
gelatinase-associated
lipocalin
(NGAL),
molecule-1
(KIM-1),
cell
cycle
arrest
markers
([TIMP-2]
•[IGFBP7])
demonstrate
capability
very
prediction
accurate
stratification.
Their
incorporation
has
facilitate
timely
targeted
interventions
personalized
However,
factors
influencing
performance,
optimal
cutoffs,
cost-effectiveness,
impact
patient
outcomes
require
robust
validation
across
diverse
settings
widespread
implementation.
Addressing
these
limitations
research
can
help
translate
into
improved
prognosis,
practice.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 12, 2025
Renal
fibrosis
and
vascular
rarefaction
are
significant
complications
of
ischemia/reperfusion
(I/R)
injury.
Human
umbilical
cord
mesenchymal
cell-derived
exosomes
(hucMSC-exos)
have
shown
potential
in
mitigating
these
conditions.
This
study
investigates
the
role
miR-29a-3p
its
therapeutic
effects
on
I/R-induced
renal
damage.
Male
C57BL/6
mice
were
subjected
to
unilateral
ischemia
for
28
min
followed
by
reperfusion.
Exosomes
mimics/inhibitors
injected
into
mice.
function,
histological
analysis,
molecular
assays
performed
evaluate
integrity.
Exosome
treatment
significantly
improved
function
reduced
post-I/R.
MiR-29a-3p
was
highly
expressed
hucMSC-exos
but
models.
mimic
reduced,
while
inhibitor
exacerbated
rarefaction.
Collagen
I
TNFR1
identified
as
direct
targets
fibroblasts
endothelial
cells,
respectively.
overexpressing
provided
superior
protection
compared
unmodified
hucMSC-exos.
HucMSC-exos,
particularly
those
miR-29a-3p,
potent
against
collagen
I,
highlighting
therapy.
Nanomaterials,
Год журнала:
2021,
Номер
11(12), С. 3391 - 3391
Опубликована: Дек. 14, 2021
In
designing
a
new
drug,
considering
the
preferred
route
of
administration,
various
requirements
must
be
fulfilled.
Active
molecules
pharmacokinetics
should
reliable
with
valuable
drug
profile
as
well
well-tolerated.
Over
past
20
years,
nanotechnologies
have
provided
alternative
and
complementary
solutions
to
those
an
exclusively
pharmaceutical
chemical
nature
since
scientists
clinicians
invested
in
optimization
materials
methods
capable
regulating
effective
delivery
at
nanometer
scale.
Among
many
carriers,
lipid
nano
vesicular
ones
successfully
support
clinical
candidates
approaching
such
problems
insolubility,
biodegradation,
difficulty
overcoming
skin
biological
barriers
blood-brain
one.
this
review,
authors
discussed
structure,
biochemical
composition,
applications
nanovesicular
namely,
niosomes,
proniosomes,
ethosomes,
transferosomes,
pharmacosomes,
ufasomes,
phytosomes,
catanionic
vesicles,
extracellular
vesicles.
