Recent advances and new insights on the construction of photocatalytic systems for environmental disinfection
Journal of Environmental Management,
Год журнала:
2024,
Номер
353, С. 120235 - 120235
Опубликована: Фев. 1, 2024
Язык: Английский
Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production
Experimental Cell Research,
Год журнала:
2024,
Номер
438(1), С. 114034 - 114034
Опубликована: Апрель 6, 2024
Язык: Английский
NOX-induced oxidative stress is a primary trigger of major neurodegenerative disorders
Progress in Neurobiology,
Год журнала:
2023,
Номер
231, С. 102539 - 102539
Опубликована: Окт. 12, 2023
Neurodegenerative
diseases
(NDDs)
causing
cognitive
impairment
and
dementia
are
difficult
to
treat
due
the
lack
of
understanding
primary
initiating
factors.
Meanwhile,
major
sporadic
NDDs
share
many
risk
factors
exhibit
similar
pathologies
in
their
early
stages,
indicating
existence
common
initiation
pathways.
Glucose
hypometabolism
associated
with
oxidative
stress
is
one
such
primary,
shared
pathology,
a
likely
cause
detrimental
disease-associated
cascades;
targeting
this
pathology
may
therefore
be
an
effective
preventative
strategy
for
most
NDDs.
However,
its
exact
trigger
remain
unclear.
Recent
research
suggests
that
caused
by
NADPH
oxidase
(NOX)
activation
mechanism
among
could
prove
long-sought
ubiquitous
NDD
trigger.
We
focus
on
two
-
Alzheimer's
disease
(AD)
Parkinson's
(PD),
as
well
acquired
epilepsy
which
increasingly
recognized
comorbidity
also
discuss
available
data
suggesting
relevance
proposed
mechanisms
other
delve
into
commonalities
these
neuroinflammation
NOX
involvement
identify
potential
therapeutic
targets
gain
deeper
underlying
causes
Язык: Английский
Application of Nanomaterials and Related Drug Delivery Systems in Autophagy
Molecules,
Год журнала:
2024,
Номер
29(15), С. 3513 - 3513
Опубликована: Июль 26, 2024
Autophagy,
a
lysosomal
self-degradation
pathway,
plays
critical
role
in
cellular
homeostasis
by
degrading
endogenous
damaged
organelles
and
protein
aggregates
into
recyclable
biological
molecules.
Additionally,
it
detoxifies
extracellular
toxic
substances,
including
drugs
materials,
thereby
preserving
the
stability
of
intracellular
environment.
The
swift
progression
nanotechnology
has
led
to
an
increased
focus
on
understanding
relationship
between
nanomaterials
autophagy.
effects
various
nano
drug
delivery
systems
autophagy
their
functions
have
been
preliminarily
assessed,
revealing
that
modulation
levels
these
agents
represents
novel
response
mechanism.
Notably,
regulation
based
or
for
range
diseases
is
currently
subject
extensive
research.
Given
close
association
tumors,
emerged
as
highly
active
area
research
development
innovative
tumor
therapies.
This
review
synthesizes
current
application
potential
functions,
suggesting
new
avenue
nanomaterial-based
regulation.
Язык: Английский
Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer’s, Parkinson’s, and ALS
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12613 - 12613
Опубликована: Ноя. 24, 2024
Neurodegenerative
diseases,
such
as
Alzheimer's,
Parkinson's,
ALS,
and
Huntington's,
remain
formidable
challenges
in
medicine,
with
their
relentless
progression
limited
therapeutic
options.
These
diseases
arise
from
a
web
of
molecular
disturbances-misfolded
proteins,
chronic
neuroinflammation,
mitochondrial
dysfunction,
genetic
mutations-that
slowly
dismantle
neuronal
integrity.
Yet,
recent
scientific
breakthroughs
are
opening
new
paths
to
intervene
these
once-intractable
conditions.
This
review
synthesizes
the
latest
insights
into
underlying
dynamics
neurodegeneration,
revealing
how
intertwined
pathways
drive
course
diseases.
With
an
eye
on
most
promising
advances,
we
explore
innovative
therapies
emerging
cutting-edge
research:
nanotechnology-based
drug
delivery
systems
capable
navigating
blood-brain
barrier,
gene-editing
tools
like
CRISPR
designed
correct
harmful
variants,
stem
cell
strategies
that
not
only
replace
lost
neurons
but
foster
neuroprotective
environments.
Pharmacogenomics
is
reshaping
treatment
personalization,
enabling
tailored
align
individual
profiles,
while
diagnostics
biomarkers
ushering
era
early,
precise
disease
detection.
Furthermore,
novel
perspectives
gut-brain
axis
sparking
interest
mounting
evidence
suggests
microbiome
modulation
may
play
role
reducing
neuroinflammatory
responses
linked
neurodegenerative
progression.
Taken
together,
advances
signal
shift
toward
comprehensive,
personalized
approach
could
transform
care.
By
integrating
techniques,
this
offers
forward-looking
perspective
future
where
treatments
aim
just
manage
symptoms
fundamentally
alter
progression,
presenting
renewed
hope
for
improved
patient
outcomes.
Язык: Английский
TRIB3 knockdown increases the sensitivity of clear cell renal cell carcinoma to sunitinib by inducing ferroptosis
Cellular Signalling,
Год журнала:
2024,
Номер
124, С. 111421 - 111421
Опубликована: Сен. 17, 2024
Язык: Английский
The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death
Jiufeng Xie,
Cui Yuan,
Sen Yang
и другие.
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Ноя. 8, 2024
Coronavirus
disease
2019
(COVID-19)
represents
the
novel
respiratory
infectious
disorder
caused
by
severe
acute
syndrome
coronavirus
2
(SARS-CoV-2)
and
is
characterized
rapid
spread
throughout
world.
Reactive
oxygen
species
(ROS)
account
for
cellular
metabolic
by-products,
excessive
ROS
accumulation
can
induce
oxidative
stress
due
to
insufficient
endogenous
antioxidant
ability.
In
case
of
stress,
production
exceeds
capacity,
thus
leading
cell
death.
SARS-CoV-2
activate
different
death
pathways
in
context
infection
host
cells,
such
as
neutrophil
extracellular
trap
(NET)osis,
ferroptosis,
apoptosis,
pyroptosis,
necroptosis
autophagy,
which
are
closely
related
signalling
control.
this
review,
we
comprehensively
elucidated
relationship
between
generation
cells
after
infection,
leads
development
COVID-19,
aiming
provide
a
reasonable
basis
existing
interventions
further
therapies
against
SARS-CoV-2.
Язык: Английский