Abstract
Sciatica
is
a
severe
form
of
pain
caused
by
compression
the
sciatic
nerve
that
radiates
from
back
toward
hip
and
outer
side
leg.
Conventional
treatments
for
sciatica
include
medication,
physical
therapy,
surgery
in
cases.
However,
these
approaches
can
be
invasive
costly
may
not
provide
long‐term
relief.
Occupational
therapy
refers
to
intentional
strategic
application
various
activities
associated
with
daily
life,
work,
education,
leisure
address
functional
impairments.
Focusing
on
targeted
exercises,
manual
techniques,
ergonomic
modifications
alleviate
symptoms
improve
function,
it
offers
promising
alternative
medical
treatments.
interventions
reduce
pain,
increase
mobility,
enhance
overall
quality
life.
As
an
empowering
approach,
such
techniques
aid
symptom
management
independence.
This
article
explores
occupational
therapy‐based
assessments,
interventions,
outcomes,
progress
tracking,
pharmacotherapy,
challenges
owing
surgical
approaches,
devices
rehabilitation,
assessments
aimed
at
improving
life
individuals
affected
this
condition.
Future
research
should
focus
developing
validating
new
assessment
tools
outcome
measures
specific
sciatica,
enabling
more
accurate
evaluation
monitoring.
Biomolecules and Biomedicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 20, 2024
Lumbar
disc
herniation
(LDH)
often
results
in
significant
pain
and
disability,
histopathologic
(HP)
evaluation
of
intervertebral
discs
(IVDs)
offers
critical
insights
into
treatment
outcomes.
This
prospective
observational
study
explores
HP
changes
IVDs
their
association
with
clinical
outcomes
following
surgical
for
LDH.
A
cohort
141
patients
undergoing
MRI-confirmed
LDH
surgery
underwent
using
a
semi-quantitative
degeneration
score
(HDS).
Preoperatively
at
six-month
follow-up,
the
comprehensive
assessment
included
Oswestry
disability
index
(ODI)
visual
analog
scale
(VAS),
minimal
clinically
important
difference
(MCID)
calculated
from
ODI
VAS.
Results
indicated
associations
between
higher
HDS
adverse
outcomes,
including
persistent
greater
post-surgery.
Specifically,
an
≥
7
was
predictive
(OR
=
6.25,
95%
CI:
2.56–15.23)
measured
MCID-ODI
(AUC:
0.692,
0.609–0.767,
P
<
0.001),
8
1.72,
1.04–2.77)
MCID-VAS
(AUC
0.628,
0.598–0.737,
0.008),
highlighting
diagnostic
potential
assessing
postoperative
recovery.
underscores
to
provide
valuable
disease
progression
patients,
complementing
conventional
radiologic
methods.
The
findings
support
application
personalized
strategies
based
on
while
acknowledging
challenges
interpretation
implementation.
Advancements
in
minimally
invasive
spine
surgery
have
markedly
enhanced
patient
outcomes
the
management
of
lumbar
intervertebral
disc
herniation
and
degenerative
disorders.
The
Unilateral
Biportal
Endoscopic
Interlaminar
Lumbar
Intervertebral
Discectomy
spinal
nerve
decompression
are
prominent
these
methods.
This
method
is
based
on
principles
established
by
several
endoscopic
techniques,
which
lauded
for
their
limited
invasiveness,
less
trauma,
expedited
recovery
periods
contrast
to
conventional
open
operations.
177
patients
treated
with
Transforaminal
were
selected
assigned
into
Sutured
(39
patients)
Un-sutured
groups
(138
patients).
Different
variables,
including
clinical
estimated
cost,
evaluated
using
IBM
SPSS
27.0.1
a
p-value
<
0.05
considered
statistically
significant.
study
identified
disparities
outcomes,
such
as
reoperation
problems,
durations,
projected
costs
between
two
groups.
Reoperation
rates
lower
sutured
group.
had
shorter
time.
Both
comparable
Visual
Analog
Scale
(VAS)
Japanese
Orthopaedic
Association
(JOA)
scores.
similar
Body
Mass
Indexes
(BMIs)
throughout
hospitalization.
equal
discharge
satisfaction
There
not
much
variation
surgical
bleeding
across
Follow-up
times
identical
both
(26.46
±
2.01
group
26.83
2.68
un-sutured
group).
showed
slight
difference
costs,
averaging
RMB
29,234.78
5,265.83,
compared
22,311.10
3,527.00
Annulus
fibrosus
suturing
during
may
increase
time
expense
reduce
risk
recurrent
reoperation.
non-sutured
techniques
results
low
intraoperative
blood
loss,
making
them
feasible
alternatives
depending
situation
demands.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(10), С. 3390 - 3390
Опубликована: Май 13, 2025
Background/Objectives:
Lumbar
spine
surgery
has
undergone
significant
technological
transformation
in
recent
years,
driven
by
the
goals
of
minimizing
invasiveness,
improving
precision,
and
enhancing
clinical
outcomes.
Emerging
tools-including
robotics,
augmented
reality,
computer-assisted
navigation,
artificial
intelligence-have
complemented
evolution
minimally
invasive
surgical
(MIS)
approaches,
such
as
endoscopic
lateral
interbody
fusions.
Methods:
This
systematic
review
evaluates
literature
from
February
2020
to
2025
on
procedural
innovations
LSS.
Eligible
studies
focused
degenerative
lumbar
pathologies,
advanced
technologies,
reported
or
perioperative
Randomized
controlled
trials,
comparative
studies,
meta-analyses,
large
case
series
were
included.
Results:
A
total
32
met
inclusion
criteria.
Robotic-assisted
demonstrated
high
accuracy
pedicle
screw
placement
(~92-94%)
reduced
intraoperative
blood
loss
radiation
exposure,
although
long-term
outcomes
comparable
conventional
techniques.
Intraoperative
navigation
improved
instrumentation
while
AR
enhanced
ergonomic
workflow
surgeon
distraction.
AI
tools
showed
promise
planning,
guidance,
outcome
prediction
but
lacked
definitive
evidence
superiority.
MIS
techniques-including
discectomy
MIS-TLIF-offered
loss,
shorter
hospital
stays,
faster
recovery,
with
equivalent
pain
relief,
fusion
rates,
complication
profiles
compared
open
procedures.
Lateral
oblique
approaches
(XLIF/OLIF)
further
optimized
alignment
indirect
decompression,
favorable
metrics.
Conclusions:
Recent
have
technical
precision
efficiency
without
compromising
patient
While
short-term
benefits
are
clear,
advantages
cost-effectiveness
require
investigation.
Integration
AI,
into
reflects
an
ongoing
shift
toward
personalized,
data-driven,
less
care.
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Май 30, 2025
Abstract
Phase
separation
is
fundamental
for
cellular
organization
and
function,
profoundly
impacting
a
range
of
biological
processes
from
gene
expression
to
signaling
pathways,
pivotal
in
stem
cell
biology.
This
review
explores
the
primary
types
phase
their
mechanisms,
emphasizing
how
integral
maintaining
integrity
its
significant
implications
disease
progression.
It
elaborates
on
current
insights
into
influences
biology,
discussing
challenges
translating
these
practical
applications.
These
complex
dynamics
separation,
need
advanced
imaging
techniques,
necessity
real-time,
situ
analysis
within
living
systems.
Addressing
through
innovative
methodologies
gaining
deeper
understanding
molecular
interactions
that
govern
cells
are
essential
developing
precise,
targeted
therapies.
Ultimately,
advancing
our
could
transform
cell-based
therapeutic
approaches,
opening
up
novel
strategies
treatment
advancements
regenerative
medicine.
European Journal of Medical and Health Research,
Год журнала:
2024,
Номер
2(3), С. 137 - 147
Опубликована: Май 1, 2024
The
opioid
epidemic
poses
a
significant
public
health
challenge,
stemming
from
the
widespread
misuse
and
abuse
of
opioids
for
pain
management.
Stem
cell
therapy
(SCT)
non-opioid
anesthesia
emerge
as
promising
alternatives
to
traditional
opioid-based
treatments,
offering
effective
relief
while
mitigating
risks
addiction
overdose.
SCT
involves
undifferentiated
cells,
which
can
differentiate
into
various
types
promote
tissue
repair
alleviate
pain.
Non-opioid
employs
techniques
such
regional
multimodal
analgesia
manage
during
surgeries
without
relying
on
opioids.Both
demonstrate
advantages
in
reducing
dependence
improving
patient
outcomes.
releases
neurotrophic
factors
neuropathic
prevent
tolerance,
provides
robust
control
with
fewer
side
effects.Although
further
research
is
needed
optimize
their
use,
integration
affords
comprehensive
approach
addressing
crisis.
By
prescriptions
promoting
safer
management
practices,
these
interventions
not
only
benefit
individual
patients
but
also
socioeconomic
burden
opioid-related
complications.
Ethical
considerations,
informed
consent
autonomy,
are
essential
ensuring
alternative
treatments’
responsible
equitable
implementation.
represent
advancements
combating
outcomes.Abbreviations:
CPSP:
Chronic
Post-Surgical
Pain;
ESCs:
Embryonic
Cells;
HSCs:
Hematopoietic
MSCs:
Mesenchymal
NSAIDs:
Nonsteroidal
Anti-Inflammatory
Drugs;
OFA:
Opioid-Free
Anesthesia;
PONV:
Postoperative
Nausea
Vomiting;
QoL:
Quality
Life;
SCT:
Cell
Therapy;
TKA:
Total
Knee
Arthroplasty
