The Inflammation-Induced Dysregulation of Reelin Homeostasis Hypothesis of Alzheimer’s Disease

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 100(4), С. 1099 - 1119

Опубликована: Июль 12, 2024

Alzheimer's disease (AD) accounts for most dementia cases, but we lack a complete understanding of the mechanisms responsible core pathology associated with (e.g., amyloid plaque and neurofibrillary tangles). Inflammation has been identified as key contributor AD pathology, recent evidence pointing towards Reelin dysregulation being inflammation. Here describe signaling outline existing research involving in Research is described pertaining to inflammatory immunological functions before propose mechanism through which inflammation renders susceptible resulting induction exacerbation pathology. Based on this hypothesis, it predicted that disorders both (including peripheral neuroinflammation) upregulated expression downregulation) have elevated risk developing AD. We conclude description various

Язык: Английский

SARS-CoV-2: A synergy to the Alzheimer’s disease

Journal of NeuroVirology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Язык: Английский