Purpose:
This
study
aimed
to
describe
the
molecular
epidemiology
and
seasonality
of
human
rhinovirus
(HRV)
in
chronic
obstructive
pulmonary
disease
(COPD)
its
association
with
COPD
exacerbations
Abu
Dhabi,
United
Arab
Emirates
(UAE).
Methods:
Sputum
specimens
were
collected
for
analysis
from
all
patients
who
visited
a
medical
center
November
2021
October
2022.
The
real-time
quantitative
polymerase
chain
reaction
(qPCR)
test
was
used
detect
HRV.
Results:
Of
78
included
study,
58
(74%)
pa-tients
presented
one
or
more
exacerbation
episodes.
incidence
peaked
over
winter
substantially
decreased
during
summer.
HRV
positivity
(E1)
11/58
(19%)
15/58
(26%)
two
weeks
after
episode
(E2).
There
no
significant
difference
load
these
patients.
No
statistically
observed
detection
compared
stable
COPD.
Conclusion:
is
first
assess
between
by
qPCR
UAE.
high
sensitivity
detec-tion
technology
helped
collect
reliable
epidemiologic
data.
Few
studies
have
provided
similar
Middle
East
study's
pattern
parallels
that
temperate
countries.
information
can
help
future,
extensive
surveillance
res-piratory
viruses
UAE
their
exacerbations.
Infection and Drug Resistance,
Год журнала:
2025,
Номер
Volume 18, С. 285 - 295
Опубликована: Янв. 1, 2025
Pneumocystis
jirovecii
pneumonia
(PJP)
is
an
opportunistic
fungal
infection
that
often
occurs
secondary
to
human
immunodeficiency
virus
(HIV)
infection.However,
for
non-HIV
immunocompromised
patients,
such
as
those
undergoing
novel
immunosuppressive
treatments
manage
malignancies,
organ
transplants,
or
connective
tissue
diseases,
PJP
emerging
increasing
threat.The
clinical
manifestations
of
in
HIV-infected
and
non-HIV-infected
patients
differ
significantly.In
progresses
rapidly
challenging
diagnose,
resulting
severe
respiratory
failure
a
poor
prognosis.We
describe
lymphocytopenia
two
women
who
were
recently
treated
with
methotrexate,
tacrolimus,
corticosteroids
therapy
following
adjuvant
chemotherapy
breast
cancer
kidney
transplantation.The
initial
examination
included
high-resolution
chest
CT
indicating
atypical
pneumonia,
treatment
was
initiated
trimethoprim
-sulfamethoxazole
oxygen
support.Subsequently,
bronchoscopy
bronchoalveolar
lavage
mNGS
detected
jirovecii.After
3
weeks
cotrimoxazole,
the
recovered
significantly
their
condition
stable.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 4086 - 4086
Опубликована: Фев. 17, 2023
The
wide
diversity
of
microbiota
at
the
genera
and
species
levels
across
sites
individuals
is
related
to
various
causes
observed
differences
between
individuals.
Efforts
are
underway
further
understand
characterize
human-associated
its
microbiome.
Using
16S
rDNA
as
a
genetic
marker
for
bacterial
identification
improved
detection
profiling
qualitative
quantitative
changes
within
population.
In
this
light,
review
provides
comprehensive
overview
basic
concepts
clinical
applications
respiratory
microbiome,
alongside
an
in-depth
explanation
molecular
targets
potential
relationship
microbiome
disease
pathogenesis.
paucity
robust
evidence
supporting
correlation
pathogenesis
currently
main
challenge
not
considering
novel
druggable
target
therapeutic
intervention.
Therefore,
studies
needed,
especially
prospective
studies,
identify
other
drivers
better
in
lung
along
with
association
medications.
Thus,
finding
unfolding
significance
would
be
crucial.
Journal of Personalized Medicine,
Год журнала:
2023,
Номер
13(4), С. 677 - 677
Опубликована: Апрель 18, 2023
Asthma
and
COPD
have
characteristic
symptoms,
yet
patients
with
both
are
prevalent.
Despite
this,
there
is
currently
no
globally
accepted
definition
for
the
overlap
between
asthma
COPD,
commonly
referred
to
as
asthma–COPD
(ACO).
Generally,
ACO
not
considered
a
distinct
disease
or
symptom
from
either
clinical
mechanistic
perspectives.
However,
identifying
who
present
conditions
crucial
guiding
therapy.
Similar
heterogeneous
presumably
multiple
underlying
processes.
The
variability
of
led
establishment
definitions
describing
condition’s
essential
clinical,
physiological,
molecular
characteristics.
comprises
numerous
phenotypes,
which
affects
optimal
medication
choice
can
serve
predictor
prognosis.
Various
phenotypes
been
suggested
based
on
host
factors
including
but
limited
demographics,
spirometric
findings,
smoking
history,
airway
inflammation.
This
review
provides
comprehensive
guide
be
used
in
practice
available
data.
Future
longitudinal
studies
must
evaluate
stability
over
time
explore
their
predictive
powers
facilitate
more
precise
effective
management
approach.
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(6), С. 2118 - 2118
Опубликована: Март 8, 2023
The
immediate
aim
of
this
study
was
to
comparatively
examine
the
bacterial
respiratory
microbiome
patients
in
a
stable
state
and
during
an
exacerbation
asthma–COPD
(chronic
obstructive
pulmonary
disease)
overlap
(ACO).
This
prospective
observational
took
place
Jordan
between
1
September
2021
30
April
2022.
Sputum
samples
from
with
recognized
ACO
were
acquired
within
48
h
onset
again
at
3
weeks
following
exacerbation.
next-generation
sequencing
Illumina
MiSeq
employed
uncovered
significantly
high
diversity
sputa.
results
showed
significant
decrease
taxonomic
richness
sputum
collected
episodes
compared
those
(p
=
0.008),
increase
evenness
<
0.005).
change
composition
airway
community
suggests
that
replacement
portion
certain
microorganisms
may
play
role
microbial
observed
Greater
knowledge
link
could
allow
for
more
focused
administration
antibiotics,
especially
exacerbations,
improving
clinical
efficacy
patient
outcomes.
Libyan Journal of Medicine,
Год журнала:
2024,
Номер
19(1)
Опубликована: Янв. 30, 2024
This
study
aimed
to
describe
the
molecular
epidemiology
and
seasonality
of
human
rhinovirus
(HRV)
in
chronic
obstructive
pulmonary
disease
(COPD)
its
association
with
COPD
exacerbations
Abu
Dhabi,
United
Arab
Emirates
(UAE).
Sputum
specimens
were
collected
for
analysis
from
all
patients
who
visited
a
medical
center
November
2021
October
2022.
The
real-time
quantitative
polymerase
chain
reaction
(qPCR)
test
was
used
detect
HRV.
Of
78
included
study,
58
(74%)
presented
one
or
more
exacerbation
episodes.
incidence
peaked
over
winter
substantially
decreased
during
summer.
HRV
positivity
(E1)
11/58
(19%)
15/58
(26%)
two
weeks
after
episode
(E2).
There
no
significant
difference
load
these
patients.
No
statistically
observed
detection
compared
stable
COPD.
is
first
assess
between
by
qPCR
UAE.
high
sensitivity
technology
helped
collect
reliable
epidemiologic
data.
Few
studies
have
provided
similar
Middle
East
study’s
pattern
parallels
that
temperate
countries.
information
can
help
future,
extensive
surveillance
respiratory
viruses
UAE
their
exacerbations.
Therapeutic Advances in Infectious Disease,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 1, 2024
Background
and
aims:
The
presence
of
fungal
infections
has
been
described
in
patients
after
recovering
from
COVID-19.
This
study
aims
to
conduct
a
systematic
review
studies
that
reported
(
Mucor
spp.,
Pneumocystis
jirovecii,
or
Aspergillus
spp.)
adults
Methods:
We
performed
through
PubMed,
Web
Science,
OVID-Medline,
Embase,
Scopus.
selection
process
was
independently
by
at
least
two
authors.
risk
bias
assessment
using
the
Newcastle–Ottawa
Scale
for
cohort
case–control
studies,
Joanna
Briggs
Institute’s
Checklists
Case
Series
Reports.
Results:
search
found
33
meeting
all
inclusion
criteria.
There
total
population
774
participants,
ranging
21
87
years.
From
them,
746
developed
infection.
In
19
spp.
as
main
mycosis.
10
P.
jirovecii
seven
Regarding
quality
assessment,
12
were
classified
low
remaining
high
bias.
Conclusion:
Patients’
clinical
presentation
prognosis
COVID-19
with
infection
differ
those
acute
without
Expert Review of Respiratory Medicine,
Год журнала:
2022,
Номер
16(11-12), С. 1167 - 1190
Опубликована: Ноя. 2, 2022
Introduction
Pneumocystis
jirovecii
is
an
opportunistic,
human-specific
fungus
that
causes
pneumonia
(PCP).
PCP
symptoms
are
nonspecific.
A
patient
with
P.
and
another
lung
infection
faces
a
diagnostic
challenge.
It
may
be
difficult
to
determine
which
of
these
agents
responsible
for
the
clinical
symptoms,
preventing
effective
treatment.
Diagnostic
treatment
efforts
have
been
made
more
by
rising
frequency
coronavirus
2019
(COVID-19)
co-occur.Areas
covered
Herein,
we
provide
comprehensive
review
pharmacological
recommendations
along
literature
in
immunocompromised
patients
focusing
on
HIV-uninfected
patients.Expert
Opinion
masked
identifying
co-existing
pathogens
not
necessarily
observed
infection.
Patients
severe
form
COVID-19
should
examined
underlying
immunodeficiency,
co-infections
must
considered
as
co-infection
worsen
COVID-19ʹs
severity
fatality.
investigated
risk
factors
who
come
suggestive
radiographic
but
previously
received
prophylaxis.
prophylaxis
explored
individuals
various
conditions
impair
immune
system,
depending
their
risk.
Journal of Multidisciplinary Healthcare,
Год журнала:
2024,
Номер
Volume 17, С. 391 - 404
Опубликована: Янв. 1, 2024
Purpose:
This
study
aimed
to
evaluate
Jordanian
healthcare
professionals'
knowledge,
skills,
and
experience
in
dealing
with
treating
adult
asthmatic
patients
assess
compliance
the
Global
Initiative
for
Asthma
(GINA)
guideline
recommendations
asthma
treatment
management
Jordan.
Patients
Methods:
A
cross-sectional
survey
was
conducted
Jordan
between
May
June
2023.
included
physicians,
pharmacists,
nurses
working
clinical
settings
directly
interacting
Jordan's
private
governmental
facilities
who
were
eligible
participate
this
research.
Three
primary
sections
of
an
online
constructed
using
Google
Forms
demographic
data,
a
diagnosis
illness,
list
worldwide
medical
references
asthma.
Results:
total
300
professionals,
including
pharmacists
(103),
(87),
Doctor
Pharmacy
(28),
physicians
(82),
took
part
The
respondents'
general
knowledge
nature
symptoms
is
quite
high,
exceeding
84%
86%,
respectively.
also
showed
high
degree
awareness
diagnosis.
It
revealed
that
around
one-quarter
participants
consistently
reported
severity
most
frequent
factor
influencing
decision
take
controller
or
maintenance
medicines
symptom
(reported
from
86%
participants).
GINA
guidelines
selected
as
information
source
by
almost
half
participants.
Finally,
47%
aware
GINA's
2019
adjustments
recommendations.
Conclusion:
professionals
understand
nature,
symptoms,
diagnoses
disease.
However,
many
lack
adherence,
awareness,
understanding
about
management.
More
research
required
adherence
evidence-based
impact
training
courses.
Keywords:
asthma,
GINA,
healthcare,
practitioners
