The Macular Choroidal Thickness in Danish Children with Myopia After Two-Year Low-Dose Atropine and One-Year Wash-Out: A Placebo-Controlled, Randomized Clinical Trial

Ophthalmology and Therapy, Год журнала: 2024, Номер 13(12), С. 3111 - 3122

Опубликована: Окт. 18, 2024

Our aim in this work was to investigate the macular choroidal thickness (ChT) changes 6–12-year-old Danish children with myopia during 2 years of low-dose atropine treatment and 1-year wash-out vs. placebo an investigator-initiated, placebo-controlled, double-blind randomized clinical trial. Ninety-seven participants were either 0.01% for years, 0.1% loading dose 6 months followed by 18 months, or placebo, then a wash-out. The primary outcome ChT sub-foveal inner outer superior, nasal, inferior, temporal sectors. secondary axial length (AL). Outcomes measured at baseline 6, 12, 24, 36 months. One-way analysis variance used detect differences between AL-stratified groups (< 24 mm, 24–25 > 25 mm). To determine longitudinal its effect on AL, all eyes included linear mixed modeling individual nested study ID as random effect. Longer had significantly thinner sectors (adj-P < 0.01) baseline. There no statistically significant change any sector after 3 group. Sub-foveal nasal group not different from 2-year treatment. In group, 1-mm increase AL associated 47-µm (95% confidence interval (CI): – 55; 38, adj-P 0.001). A 10-µm thicker choroid 0.13 mm CI: 0.009; 0.017, 0.001) less 3-year elongation. remained stable over follow-up. onset might predispose increased Treatment did ChT. We speculate that does primarily reduce progression via mechanism. ClinicalTrials.gov identifier, NCT03911271.

Язык: Английский

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Changes in choroidal thickness and lamina cribrosa position in subjects with overdipper pattern of arterial pressure

European Journal of Ophthalmology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 15, 2024

Introduction The purpose is to analyze the changes produced in subjects with an overdipper pattern of ambulatory blood pressure monitoring aim understanding pathophysiology normal tension glaucoma. Methods A cross sectional study was performed patients exhibiting and non-overdipper patterns, respectively. Different optic parameters were assessed including analysis ganglion cell layer (GCL), peripapillary retinal nerve fiber (pRNFL) Bruch's membrane opening-minimum rim width (BMO-MRW), as well choroidal thickness (CT) lamina cribrosa (LC) position at two different periods day (early morning evening). Results total 80 eyes (42 38 non-overdipper) analyzed. shortening distance beginning end LC objectified ( p < 0.003) a statistically significant shift between evening measurements 0.023). In addition, thickening found 13 horizontal vertical plane CT 0.029) both groups morning. No differences pRNFL, BMO-MRW GCL measures objectified. Conclusions Morning assessment showed deeper comparison values. increase these subjects. Altogether, findings could illustrate etiopathogenic mechanism damage glaucoma associated pattern.

Язык: Английский

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Choroidal thickness measurements in young Saudi adult population: a cross-sectional study

International Journal of Ophthalmology, Год журнала: 2023, Номер 16(11), С. 1814 - 1819

Опубликована: Окт. 25, 2023

To determine the choroidal thickness (CT) in young healthy Saudi adults using spectral-domain optical coherence tomography (SD-OCT) with an automated CT segmentation software.Fifty-eight (total of 116 eyes), 39 males and 19 females participated this study between ages 18 38y (mean 22.65±3.9y). All participants underwent ophthalmic screening examination, including SD-OCT for measurements each quadrant egmented into five eccentric regions starting from foveal region up to 4.5 mm towards periphery.The choroid was thickest (central 1 mm, 300±60 µm) began progressively thinner beyond parafovea (1.5-2.5 284±67 peripheral (3.5-4.5 fovea, 254±83 µm). The superior showed profile (309±57 µm), while nasal exhibited thinnest (229±76 rate thinning increasing eccentricity more predominant choroid, which thinned (294±58 (158±55 inferior did not show a statistically significant (all P>0.05). There no difference gender, age, laterality eyes A association myopia subfoveal observed (Pearson's, r=0.37), regression analysis that 10.3 µm diopter increase myopia.CT depends on quadrant. across measured area adult population is comparable other previous reports. Refractive error critical evaluation.

Язык: Английский

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