Short-Term Effect of Stimulating the Pterygopalatine Ganglion Via Electroacupuncture on Choroidal Structure in Human Subjects

Translational Vision Science & Technology, Journal Year: 2024, Volume and Issue: 13(10), P. 26 - 26

Published: Oct. 16, 2024

Choroidal dysfunction is implicated in various ocular pathologies. The parasympathetic pterygopalatine ganglion (PPG) innervates orbital vessels supplying the choroid. While PPG stimulation has been shown to dilate cerebral blood flow, its effects on choroid, particularly human subjects, require further elucidation. This study aimed investigate short-term influence of via electroacupuncture choroidal structure.

Language: Английский

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The Macular Choroidal Thickness in Danish Children with Myopia After Two-Year Low-Dose Atropine and One-Year Wash-Out: A Placebo-Controlled, Randomized Clinical Trial

Ophthalmology and Therapy, Journal Year: 2024, Volume and Issue: 13(12), P. 3111 - 3122

Published: Oct. 18, 2024

Our aim in this work was to investigate the macular choroidal thickness (ChT) changes 6–12-year-old Danish children with myopia during 2 years of low-dose atropine treatment and 1-year wash-out vs. placebo an investigator-initiated, placebo-controlled, double-blind randomized clinical trial. Ninety-seven participants were either 0.01% for years, 0.1% loading dose 6 months followed by 18 months, or placebo, then a wash-out. The primary outcome ChT sub-foveal inner outer superior, nasal, inferior, temporal sectors. secondary axial length (AL). Outcomes measured at baseline 6, 12, 24, 36 months. One-way analysis variance used detect differences between AL-stratified groups (< 24 mm, 24–25 > 25 mm). To determine longitudinal its effect on AL, all eyes included linear mixed modeling individual nested study ID as random effect. Longer had significantly thinner sectors (adj-P < 0.01) baseline. There no statistically significant change any sector after 3 group. Sub-foveal nasal group not different from 2-year treatment. In group, 1-mm increase AL associated 47-µm (95% confidence interval (CI): – 55; 38, adj-P 0.001). A 10-µm thicker choroid 0.13 mm CI: 0.009; 0.017, 0.001) less 3-year elongation. remained stable over follow-up. onset might predispose increased Treatment did ChT. We speculate that does primarily reduce progression via mechanism. ClinicalTrials.gov identifier, NCT03911271.

Language: Английский

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Choroidal thickness measurements in young Saudi adult population: a cross-sectional study

International Journal of Ophthalmology, Journal Year: 2023, Volume and Issue: 16(11), P. 1814 - 1819

Published: Oct. 25, 2023

To determine the choroidal thickness (CT) in young healthy Saudi adults using spectral-domain optical coherence tomography (SD-OCT) with an automated CT segmentation software.Fifty-eight (total of 116 eyes), 39 males and 19 females participated this study between ages 18 38y (mean 22.65±3.9y). All participants underwent ophthalmic screening examination, including SD-OCT for measurements each quadrant egmented into five eccentric regions starting from foveal region up to 4.5 mm towards periphery.The choroid was thickest (central 1 mm, 300±60 µm) began progressively thinner beyond parafovea (1.5-2.5 284±67 peripheral (3.5-4.5 fovea, 254±83 µm). The superior showed profile (309±57 µm), while nasal exhibited thinnest (229±76 rate thinning increasing eccentricity more predominant choroid, which thinned (294±58 (158±55 inferior did not show a statistically significant (all P>0.05). There no difference gender, age, laterality eyes A association myopia subfoveal observed (Pearson's, r=0.37), regression analysis that 10.3 µm diopter increase myopia.CT depends on quadrant. across measured area adult population is comparable other previous reports. Refractive error critical evaluation.

Language: Английский

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