Cancer Biology & Therapy,
Год журнала:
2020,
Номер
21(9), С. 806 - 814
Опубликована: Июль 20, 2020
Globally,
lung
cancer
is
known
as
a
major
cause
of
cancer-associated
death
and
non-small-cell
(NSCLC)
accounts
for
majority
all
cases.
Growing
evidence
has
emerged
that
long
non-coding
RNAs
(lncRNAs)
act
vital
regulatory
molecules
in
various
malignancies.
Nevertheless,
the
function
SLCO4A1
antisense
RNA
1(SLCO4A1-AS1)
NSCLC
vague.
This
study
intended
to
investigate
biological
role
probable
mechanism
SLCO4A1-AS1
NSCLC.
qRT-PCR
revealed
level
was
upregulated
Function
assays
manifested
silence
attenuated
cell
proliferation,
migration
invasion
but
promoted
apoptosis.
Furthermore,
we
disclosed
activated
NF-κB
pathway
NSCLC,
IKKα,
an
pathway-related
gene,
possessed
enhanced
tissues
cells.
Importantly,
miR-223-3p
bound
with
IKKα.
Further,
competitively
increase
IKKα
expression,
thereby
activating
signaling
pathway.
In
conclusion,
drove
progression
by
via
sponging
enhance
expression.
Thus,
might
be
promising
biomarker
treatment.
Briefings in Bioinformatics,
Год журнала:
2021,
Номер
23(1)
Опубликована: Сен. 8, 2021
Ferroptosis
is
a
form
of
regulated
cell
death
initiated
by
oxidative
perturbations
that
can
be
blocked
iron
chelators
and
lipophilic
antioxidants,
ferroptosis
may
the
silver
bullet
treatment
for
multiple
cancers,
including
immunotherapy-
chemotherapy-insensitive
cancers
such
as
pancreatic
ductal
adenocarcinoma
(PDAC).
Numerous
studies
have
noted
long
non-coding
RNAs
(lncRNAs)
regulate
biological
behaviour
cancer
cells
binding
to
DNA,
RNA
protein.
However,
few
reported
role
lncRNAs
in
processes
function
ferroptosis-associated
lncRNAs.
The
primary
objective
present
study
was
identify
ferroptosis-related
using
bioinformatic
approaches
combined
with
experimental
validation.
second
construct
prognostic
model
predict
overall
survival
patients
PDAC.
identified
approach
validated
them
an
independent
cohort
from
Fudan
University
Shanghai
Cancer
Center.
lncRNA
SLCO4A1-AS1
novel
molecule
mediating
resistance
vitro.
A
algorithm
used
'0
or
1'
matrix-based
prognosis
model,
which
showed
promising
diagnostic
accuracy
potential
clinical
translation
(area
under
curve
=
0.89
2-year
rate).
Notably,
molecular
subtypes
classified
risk
scores
did
not
belong
any
previously
immune
microenvironment,
metabolic
activities,
mutation
landscape
sensitivity
were
significantly
distinct
between
different
scores.
Sensitivity
(IC50)
30
common
anticancer
drugs
analysed
risks,
imatinib
axitinib
found
lower
Overall,
we
developed
accurate
based
on
expression
patterns
lncRNAs,
contribute
greatly
evaluation
patient
prognosis,
characteristics
modalities
could
further
translated
into
applications.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
154, С. 113609 - 113609
Опубликована: Авг. 27, 2022
Epigenetic
factors
are
critical
regulators
of
biological
and
pathological
mechanisms
they
could
interact
with
different
molecular
pathways.
Targeting
epigenetic
has
been
an
idea
approach
in
disease
therapy,
especially
cancer.
Accumulating
evidence
highlighted
function
long
non-coding
RNAs
(lncRNAs)
as
cancer
initiation
development
focused
on
their
association
downstream
targets.
microRNAs
(miRNAs)
the
most
well-known
targets
lncRNAs
present
review
focuses
lncRNA-miRNA
axis
malignancy
therapy
resistance
tumors.
LncRNA-miRNA
regulates
cell
death
such
apoptosis
autophagy
cancers.
This
affects
tumor
metastasis
via
regulating
EMT
MMPs.
Besides,
determines
sensitivity
cells
to
chemotherapy,
radiotherapy
immunotherapy.
Based
studies,
can
be
affected
by
drugs
genetic
tools
this
may
affect
expression
level
miRNAs
targets,
leading
suppression/progression.
LncRNAs
have
both
tumor-promoting
tumor-suppressor
functions
unique
complicated
implication
therapy.
also
other
signaling
networks
PI3K/Akt,
STAT3,
Wnt/β-catenin
EZH2
among
others.
Notably,
lncRNA/miRNA
considered
a
signature
for
diagnosis
prognosis
Autophagy,
Год журнала:
2021,
Номер
18(5), С. 949 - 970
Опубликована: Фев. 2, 2021
As
a
self-degradative
mechanism,
macroautophagy/autophagy
has
role
in
the
maintenance
of
energy
homeostasis
during
critical
periods
development
cells.
It
also
controls
cellular
damage
through
eradication
damaged
proteins
and
organelles.
This
process
is
accomplished
by
tens
ATG
(autophagy-related)
proteins.
Recent
studies
have
shown
involvement
non-coding
RNAs
regulation
autophagy.
These
transcripts
mostly
modulate
expression
genes.
Both
long
(lncRNAs)
microRNAs
(miRNAs)
been
to
autophagy
mechanism.
Levels
several
lncRNAs
miRNAs
are
altered
this
process.
In
present
review,
we
discuss
diverse
contexts
such
as
cancer,
deep
vein
thrombosis,
spinal
cord
injury,
diabetes
its
complications,
acute
myocardial
infarction,
osteoarthritis,
pre-eclampsia
epilepsy.Abbreviations:
AMI:
infarction;
ATG:
autophagy-related;
lncRNA:
RNA;
miRNA:
microRNA.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Фев. 2, 2022
Colorectal
cancer
(CRC)
is
a
common
malignancy
with
high
mortality.
However,
the
molecular
mechanisms
underlying
CRC
remain
unclear.
Controversies
over
exact
functions
of
non-coding
RNAs
(ncRNAs)
in
progression
have
been
prevailing
for
multiple
years.
Recently,
accumulating
evidence
has
demonstrated
regulatory
roles
ncRNAs
various
human
cancers,
including
CRC.
The
intracellular
signaling
pathways
by
which
act
on
tumor
cells
explored,
and
CRC,
studies
identified
numerous
dysregulated
that
serve
as
oncogenes
or
suppressors
process
tumorigenesis
through
diverse
mechanisms.
In
this
review,
we
summarized
(mainly
lncRNAs,
miRNAs,
circRNAs)
We
also
discuss
potential
applications
diagnostic
prognostic
tools,
well
therapeutic
targets
This
review
details
strategies
trigger
recognition
CRC-related
ncRNAs,
methodologies
challenges
studying
these
molecules,
forthcoming
clinical
findings.
Journal of Biomedical Science,
Год журнала:
2022,
Номер
29(1)
Опубликована: Янв. 17, 2022
Abstract
Background
SLCO4A1-AS1
was
found
to
be
upregulated
in
several
cancer
types,
including
colorectal
(CRC).
However,
the
detailed
roles
of
CRC
remain
elucidated.
Therefore,
we
investigated
functions,
mechanism,
and
clinical
significance
tumourigenesis.
Methods
We
measured
expression
tissues
using
qRT-PCR
determined
its
correlation
with
patient
prognosis.
Promoter
methylation
analyses
were
used
assess
status
SLCO4A1-AS1.
Gain-
loss-of-function
assays
evaluate
effects
on
growth
vitro
vivo.
RNA
pull-down,
immunoprecipitation,
RNA-seq,
luciferase
reporter
immunohistochemistry
performed
identify
molecular
mechanism
CRC.
Results
frequently
based
multiple
cohorts
associated
poor
prognoses.
Aberrant
overexpression
is
partly
attributed
DNA
hypomethylation
promoter.
Ectopic
promoted
cell
growth,
whereas
knockdown
repressed
proliferation
both
Mechanistic
investigations
revealed
that
functions
as
a
scaffold
strengthen
interaction
between
Hsp90
Cdk2,
promoting
protein
stability
Cdk2.
The
SLCO4A1-AS1-induced
increase
Cdk2
levels
activates
c-Myc
signalling
pathway
by
phosphorylation
at
Ser62,
resulting
increased
tumour
growth.
Conclusions
Our
data
demonstrate
acts
an
oncogene
regulating
Hsp90/Cdk2/c-Myc
axis,
supporting
potential
therapeutic
target
prognostic
factor
for
Genes & Diseases,
Год журнала:
2023,
Номер
11(1), С. 367 - 381
Опубликована: Июнь 16, 2023
The
incidence
and
mortality
rates
of
cancer
are
increasing
every
year
worldwide
but
the
survival
rate
patients
is
still
unsatisfactory.
Therefore,
it
necessary
to
further
elucidate
molecular
mechanisms
involved
in
tumor
development
drug
resistance
improve
cure
or
rates.
In
recent
years,
autophagy
has
become
a
hot
topic
field
oncology
research,
which
plays
double-edged
role
tumorigenesis,
progression,
resistance.
Meanwhile,
long
non-coding
RNA
(lncRNA)
also
been
shown
regulate
autophagy,
two-sided
nature
determines
dual
regulatory
autophagy-related
lncRNAs
(ARlncRNAs).
ARlncRNAs
can
be
effective
therapeutic
targets
for
various
cancers.
Furthermore,
high
abundance
stability
tissues
make
them
promising
biomarkers.
this
review,
we
summarized
roles
cell
proliferation,
apoptosis,
migration,
invasion,
resistance,
angiogenesis,
radiation
immune
regulation.
addition,
described
clinical
significance
these
ARlncRNAs,
including
as
biomarkers/therapeutic
their
association
with
drugs.
Cells,
Год журнала:
2023,
Номер
12(5), С. 810 - 810
Опубликована: Март 6, 2023
Cancer
has
become
a
global
health
hazard
accounting
for
10
million
deaths
in
the
year
2020.
Although
different
treatment
approaches
have
increased
patient
overall
survival,
advanced
stages
still
suffers
from
poor
clinical
outcomes.
The
ever-increasing
prevalence
of
cancer
led
to
reanalysis
cellular
and
molecular
events
hope
identify
develop
cure
this
multigenic
disease.
Autophagy,
an
evolutionary
conserved
catabolic
process,
eliminates
protein
aggregates
damaged
organelles
maintain
homeostasis.
Accumulating
evidence
implicated
deregulation
autophagic
pathways
be
associated
with
various
hallmarks
cancer.
Autophagy
exhibits
both
tumor-promoting
suppressive
effects
based
on
tumor
stage
grades.
Majorly,
it
maintains
microenvironment
homeostasis
by
promoting
viability
nutrient
recycling
under
hypoxic
nutrient-deprived
conditions.
Recent
investigations
discovered
long
non-coding
RNAs
(lncRNAs)
as
master
regulators
gene
expression.
lncRNAs,
sequestering
autophagy-related
microRNAs,
been
known
modulate
cancer,
such
proliferation,
EMT,
migration,
invasion,
angiogenesis,
metastasis.
This
review
delineates
mechanistic
role
lncRNAs
involved
modulating
autophagy
their
related
proteins
cancers.
Epigenetics & Chromatin,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 15, 2025
Colorectal
cancer
(CRC)
remains
one
of
the
most
common
causes
cancer-related
mortality
worldwide.
Its
progression
is
influenced
by
complex
interactions
involving
genetic,
epigenetic,
and
environmental
factors.
Non-coding
RNAs
(ncRNAs),
including
microRNAs
(miRNAs),
long
non-coding
(lncRNAs),
circular
(circRNAs),
have
been
identified
as
key
regulators
gene
expression,
affecting
diverse
biological
processes,
notably
programmed
cell
death
(PCD).
This
review
aims
to
explore
relationship
between
ncRNAs
PCD
in
CRC,
focusing
on
how
influence
survival,
proliferation,
treatment
resistance.
A
comprehensive
literature
analysis
was
conducted
examine
recent
findings
role
modulating
various
mechanisms,
apoptosis,
autophagy,
necroptosis,
pyroptosis,
their
impact
CRC
development
therapeutic
response.
were
found
significantly
regulate
pathways,
impacting
tumor
growth,
metastasis,
sensitivity
CRC.
Their
these
pathways
highlights
potential
biomarkers
for
early
detection
targets
innovative
interventions.
Understanding
involvement
regulation
offers
new
insights
into
biology.
The
targeted
modulation
ncRNA-PCD
presents
promising
avenues
personalized
treatment,
which
may
improve
patient
outcomes
enhancing
effectiveness
reducing
