Long non-coding RNA SLCO4A1-AS1 drives the progression of non-small-cell lung cancer by modulating miR-223-3p/IKKα/NF-κB signaling DOI Open Access
Qingpeng Li, Bo Jiang, Qi Yang

et al.

Cancer Biology & Therapy, Journal Year: 2020, Volume and Issue: 21(9), P. 806 - 814

Published: July 20, 2020

Globally, lung cancer is known as a major cause of cancer-associated death and non-small-cell (NSCLC) accounts for majority all cases. Growing evidence has emerged that long non-coding RNAs (lncRNAs) act vital regulatory molecules in various malignancies. Nevertheless, the function SLCO4A1 antisense RNA 1(SLCO4A1-AS1) NSCLC vague. This study intended to investigate biological role probable mechanism SLCO4A1-AS1 NSCLC. qRT-PCR revealed level was upregulated Function assays manifested silence attenuated cell proliferation, migration invasion but promoted apoptosis. Furthermore, we disclosed activated NF-κB pathway NSCLC, IKKα, an pathway-related gene, possessed enhanced tissues cells. Importantly, miR-223-3p bound with IKKα. Further, competitively increase IKKα expression, thereby activating signaling pathway. In conclusion, drove progression by via sponging enhance expression. Thus, might be promising biomarker treatment.

Language: Английский

Ferroptosis-related lncRNA pairs to predict the clinical outcome and molecular characteristics of pancreatic ductal adenocarcinoma DOI
Rong Tang, Zijian Wu, Zeyin Rong

et al.

Briefings in Bioinformatics, Journal Year: 2021, Volume and Issue: 23(1)

Published: Sept. 8, 2021

Ferroptosis is a form of regulated cell death initiated by oxidative perturbations that can be blocked iron chelators and lipophilic antioxidants, ferroptosis may the silver bullet treatment for multiple cancers, including immunotherapy- chemotherapy-insensitive cancers such as pancreatic ductal adenocarcinoma (PDAC). Numerous studies have noted long non-coding RNAs (lncRNAs) regulate biological behaviour cancer cells binding to DNA, RNA protein. However, few reported role lncRNAs in processes function ferroptosis-associated lncRNAs. The primary objective present study was identify ferroptosis-related using bioinformatic approaches combined with experimental validation. second construct prognostic model predict overall survival patients PDAC. identified approach validated them an independent cohort from Fudan University Shanghai Cancer Center. lncRNA SLCO4A1-AS1 novel molecule mediating resistance vitro. A algorithm used '0 or 1' matrix-based prognosis model, which showed promising diagnostic accuracy potential clinical translation (area under curve = 0.89 2-year rate). Notably, molecular subtypes classified risk scores did not belong any previously immune microenvironment, metabolic activities, mutation landscape sensitivity were significantly distinct between different scores. Sensitivity (IC50) 30 common anticancer drugs analysed risks, imatinib axitinib found lower Overall, we developed accurate based on expression patterns lncRNAs, contribute greatly evaluation patient prognosis, characteristics modalities could further translated into applications.

Language: Английский

Citations

68
LncRNA-miRNA axis in tumor progression and therapy response: An emphasis on molecular interactions and therapeutic interventions DOI Open Access
Maliheh Entezari, Afshin Taheriazam,

Sima Orouei

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113609 - 113609

Published: Aug. 27, 2022

Epigenetic factors are critical regulators of biological and pathological mechanisms they could interact with different molecular pathways. Targeting epigenetic has been an idea approach in disease therapy, especially cancer. Accumulating evidence highlighted function long non-coding RNAs (lncRNAs) as cancer initiation development focused on their association downstream targets. microRNAs (miRNAs) the most well-known targets lncRNAs present review focuses lncRNA-miRNA axis malignancy therapy resistance tumors. LncRNA-miRNA regulates cell death such apoptosis autophagy cancers. This affects tumor metastasis via regulating EMT MMPs. Besides, determines sensitivity cells to chemotherapy, radiotherapy immunotherapy. Based studies, can be affected by drugs genetic tools this may affect expression level miRNAs targets, leading suppression/progression. LncRNAs have both tumor-promoting tumor-suppressor functions unique complicated implication therapy. also other signaling networks PI3K/Akt, STAT3, Wnt/β-catenin EZH2 among others. Notably, lncRNA/miRNA considered a signature for diagnosis prognosis

Language: Английский

Citations

55
Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy DOI Creative Commons
Seyed Reza Taha, Mehdi Karimi, Bahar Mahdavi

et al.

Epigenetics & Chromatin, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 15, 2025

Colorectal cancer (CRC) remains one of the most common causes cancer-related mortality worldwide. Its progression is influenced by complex interactions involving genetic, epigenetic, and environmental factors. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs), have been identified as key regulators gene expression, affecting diverse biological processes, notably programmed cell death (PCD). This review aims to explore relationship between ncRNAs PCD in CRC, focusing on how influence survival, proliferation, treatment resistance. A comprehensive literature analysis was conducted examine recent findings role modulating various mechanisms, apoptosis, autophagy, necroptosis, pyroptosis, their impact CRC development therapeutic response. were found significantly regulate pathways, impacting tumor growth, metastasis, sensitivity CRC. Their these pathways highlights potential biomarkers for early detection targets innovative interventions. Understanding involvement regulation offers new insights into biology. The targeted modulation ncRNA-PCD presents promising avenues personalized treatment, which may improve patient outcomes enhancing effectiveness reducing

Language: Английский

Citations

1
LncRNA signature in colorectal cancer DOI
Soudeh Ghafouri‐Fard, Bashdar Mahmud Hussen, Alireza Gharebaghi

et al.

Pathology - Research and Practice, Journal Year: 2021, Volume and Issue: 222, P. 153432 - 153432

Published: April 7, 2021

Language: Английский

Citations

56
Exploring the role of non-coding RNAs in autophagy DOI Open Access
Soudeh Ghafouri‐Fard, Hamed Shoorei,

Mahdi Mohaqiq

et al.

Autophagy, Journal Year: 2021, Volume and Issue: 18(5), P. 949 - 970

Published: Feb. 2, 2021

As a self-degradative mechanism, macroautophagy/autophagy has role in the maintenance of energy homeostasis during critical periods development cells. It also controls cellular damage through eradication damaged proteins and organelles. This process is accomplished by tens ATG (autophagy-related) proteins. Recent studies have shown involvement non-coding RNAs regulation autophagy. These transcripts mostly modulate expression genes. Both long (lncRNAs) microRNAs (miRNAs) been to autophagy mechanism. Levels several lncRNAs miRNAs are altered this process. In present review, we discuss diverse contexts such as cancer, deep vein thrombosis, spinal cord injury, diabetes its complications, acute myocardial infarction, osteoarthritis, pre-eclampsia epilepsy.Abbreviations: AMI: infarction; ATG: autophagy-related; lncRNA: RNA; miRNA: microRNA.

Language: Английский

Citations

52
Long non-coding RNAs in colorectal cancer: Novel oncogenic mechanisms and promising clinical applications DOI
Yufei Yang, Xuebing Yan, Xinxiang Li

et al.

Cancer Letters, Journal Year: 2021, Volume and Issue: 504, P. 67 - 80

Published: Feb. 10, 2021

Language: Английский

Citations

42
Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms DOI Creative Commons

Zimo Jia,

Jiaqi An, Ziyuan Liu

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Feb. 2, 2022

Colorectal cancer (CRC) is a common malignancy with high mortality. However, the molecular mechanisms underlying CRC remain unclear. Controversies over exact functions of non-coding RNAs (ncRNAs) in progression have been prevailing for multiple years. Recently, accumulating evidence has demonstrated regulatory roles ncRNAs various human cancers, including CRC. The intracellular signaling pathways by which act on tumor cells explored, and CRC, studies identified numerous dysregulated that serve as oncogenes or suppressors process tumorigenesis through diverse mechanisms. In this review, we summarized (mainly lncRNAs, miRNAs, circRNAs) We also discuss potential applications diagnostic prognostic tools, well therapeutic targets This review details strategies trigger recognition CRC-related ncRNAs, methodologies challenges studying these molecules, forthcoming clinical findings.

Language: Английский

Citations

31
SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling DOI Creative Commons
Jia Zhang, Kaisa Cui, Liuying Huang

et al.

Journal of Biomedical Science, Journal Year: 2022, Volume and Issue: 29(1)

Published: Jan. 17, 2022

Abstract Background SLCO4A1-AS1 was found to be upregulated in several cancer types, including colorectal (CRC). However, the detailed roles of CRC remain elucidated. Therefore, we investigated functions, mechanism, and clinical significance tumourigenesis. Methods We measured expression tissues using qRT-PCR determined its correlation with patient prognosis. Promoter methylation analyses were used assess status SLCO4A1-AS1. Gain- loss-of-function assays evaluate effects on growth vitro vivo. RNA pull-down, immunoprecipitation, RNA-seq, luciferase reporter immunohistochemistry performed identify molecular mechanism CRC. Results frequently based multiple cohorts associated poor prognoses. Aberrant overexpression is partly attributed DNA hypomethylation promoter. Ectopic promoted cell growth, whereas knockdown repressed proliferation both Mechanistic investigations revealed that functions as a scaffold strengthen interaction between Hsp90 Cdk2, promoting protein stability Cdk2. The SLCO4A1-AS1-induced increase Cdk2 levels activates c-Myc signalling pathway by phosphorylation at Ser62, resulting increased tumour growth. Conclusions Our data demonstrate acts an oncogene regulating Hsp90/Cdk2/c-Myc axis, supporting potential therapeutic target prognostic factor for

Language: Английский

Citations

30
Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword DOI Creative Commons
Yunchao Zhang, Jiayu Tang, Cheng Wang

et al.

Genes & Diseases, Journal Year: 2023, Volume and Issue: 11(1), P. 367 - 381

Published: June 16, 2023

The incidence and mortality rates of cancer are increasing every year worldwide but the survival rate patients is still unsatisfactory. Therefore, it necessary to further elucidate molecular mechanisms involved in tumor development drug resistance improve cure or rates. In recent years, autophagy has become a hot topic field oncology research, which plays double-edged role tumorigenesis, progression, resistance. Meanwhile, long non-coding RNA (lncRNA) also been shown regulate autophagy, two-sided nature determines dual regulatory autophagy-related lncRNAs (ARlncRNAs). ARlncRNAs can be effective therapeutic targets for various cancers. Furthermore, high abundance stability tissues make them promising biomarkers. this review, we summarized roles cell proliferation, apoptosis, migration, invasion, resistance, angiogenesis, radiation immune regulation. addition, described clinical significance these ARlncRNAs, including as biomarkers/therapeutic their association with drugs.

Language: Английский

Citations

21
Targeting Autophagy Using Long Non-Coding RNAs (LncRNAs): New Landscapes in the Arena of Cancer Therapeutics DOI Creative Commons
Aviral Kumar, Sosmitha Girisa, Mohammed S. Alqahtani

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(5), P. 810 - 810

Published: March 6, 2023

Cancer has become a global health hazard accounting for 10 million deaths in the year 2020. Although different treatment approaches have increased patient overall survival, advanced stages still suffers from poor clinical outcomes. The ever-increasing prevalence of cancer led to reanalysis cellular and molecular events hope identify develop cure this multigenic disease. Autophagy, an evolutionary conserved catabolic process, eliminates protein aggregates damaged organelles maintain homeostasis. Accumulating evidence implicated deregulation autophagic pathways be associated with various hallmarks cancer. Autophagy exhibits both tumor-promoting suppressive effects based on tumor stage grades. Majorly, it maintains microenvironment homeostasis by promoting viability nutrient recycling under hypoxic nutrient-deprived conditions. Recent investigations discovered long non-coding RNAs (lncRNAs) as master regulators gene expression. lncRNAs, sequestering autophagy-related microRNAs, been known modulate cancer, such proliferation, EMT, migration, invasion, angiogenesis, metastasis. This review delineates mechanistic role lncRNAs involved modulating autophagy their related proteins cancers.

Language: Английский

Citations

20