Cancers,
Год журнала:
2021,
Номер
13(15), С. 3688 - 3688
Опубликована: Июль 22, 2021
Breast
cancer
is
the
most
commonly
diagnosed
and
leading
cause
of
mortality
among
women.
Two
thirds
patients
are
classified
as
hormone
receptor
positive,
based
on
expression
estrogen
alpha
(ERα),
main
driver
breast
cell
proliferation,
and/or
progesterone
receptor,
which
regulated
by
ERα.
Despite
presenting
best
prognosis,
these
tumors
can
recur
when
acquire
resistance
to
treatment
aromatase
inhibitors
or
antiestrogen
such
tamoxifen
(Tam).
The
mechanisms
that
involved
in
Tam
complex
involve
multiple
signaling
pathways.
Recently,
roles
for
microRNAs
lncRNAs
controlling
ER
action
have
been
described,
but
underlying
still
little
explored.
In
this
review,
we
will
discuss
current
state
knowledge
positive
cancer.
future,
be
used
identify
at
a
greater
risk
relapse
due
patterns
ncRNAs
impact
response
Tam,
order
guide
their
more
efficiently
possibly
design
therapeutic
strategies
bypass
resistance.
Acta Biochimica et Biophysica Sinica,
Год журнала:
2023,
Номер
55(5), С. 726 - 735
Опубликована: Апрель 7, 2023
Colorectal
cancer
(CRC)
ranks
the
3rd
in
types
globally.
Long
noncoding
RNAs
(lncRNAs)
are
related
to
initiation
and
progression
of
CRC.
The
current
study
plans
reveal
action
rhabdomyosarcoma
2-associated
transcript
(RMST)
results
show
that
RMST
is
downregulated
CRC
specimens
cell
lines
relative
normal
a
fetal
colon
line
(FHC),
respectively.
Elevation
represses
proliferation
colony
formation
induces
apoptosis
cells.
Bioinformatic
analysis
reveals
binding
site
for
miR-27a-3p.
direct
association
between
miR-27a-3p
confirmed
by
dual
luciferase
reporter
assay,
RNA
pull-down
real
time-quantitative
polymerase
chain
reaction
(RT-qPCR).
upregulated
tumor
specimens,
there
negative
correlation
specimens.
In
addition,
effects
overexpression
weakened
elevation
retinoid
X
receptor
(RXRα)
share
same
complementary
with
RXRα
RT-qPCR
western
blot
analysis.
Overexpression
expression
inactivates
Wnt
signaling
pathway
decreasing
β-catenin
levels
Collectively,
our
findings
pivotal
role
regulating
miR-27a-3p/RXRα
axis
counteracting
during
Reproductive Medicine and Biology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Янв. 1, 2024
To
investigate
whether
long
noncoding
RNAs
(lncRNAs)
are
involved
in
the
development
or
malignant
behavior
of
ovarian
high-grade
serous
carcinoma
(HGSC),
we
attempted
to
identify
lncRNAs
specific
HGSC.
Cell Cycle,
Год журнала:
2022,
Номер
21(16), С. 1710 - 1725
Опубликована: Май 3, 2022
This
study
explored
the
mechanism
that
ADAMTS9-AS2/miR-196b-5p/PPP1R12B/cell
cycle
pathway
axis
in
inhibiting
malignant
progression
of
esophageal
cancer
(EC),
providing
a
new
idea
for
targeted
molecular
therapy
EC.
The
expression
data
EC
tissue
were
acquired
from
TCGA
database.
target
lncRNA,
downstream
miRNA
and
its
gene
determined
by
bioinformatics
analysis.
ADAMTS9-AS2,
miR-196b-5p
PPP1R12B
levels
cells
assayed
through
qRT-PCR.
Western
blot
was
applied
to
assess
protein
level
tissues,
as
well
CDK1,
cyclin
A2,
B1
Plk1
cells.
Cell
proliferation
via
CCK-8
assay.
distribution
analyzed
flow
cytometry.
migratory
invasive
abilities
measured
scratch
healing
transwell
assays.
Pearson
correlation
analysis
utilized
analyze
relationship
among
PPP1R12B.
RIP
introduced
binding
three.
Dual-luciferase
assay
verify
sites.
tumor
formation
nude
mice
detect
tumorigenesis
vivo.
ADAMTS9-AS2
significantly
lowly
expressed
while
increased
bound
constrained
expression.
Overexpressed
inhibited
cell
downregulating
miR-196b-5p,
overexpressed
reversed
this
inhibitory
effect.
modulated
competitively
miR-196b-5p.
played
modulatory
role
pathway.
regulated
tumor-forming
ability
vivo
miR-196b-5p/PPP1R12B/cell
signaling
axis.
downregulated
adsorbing
so
regulate
inhibit
progression.
Genes,
Год журнала:
2025,
Номер
16(2), С. 229 - 229
Опубликована: Фев. 17, 2025
Prostate
cancer
(PC)
is
the
most
common
non-cutaneous
in
men
globally,
and
one
which
displays
significant
racial
disparities.
Men
of
African
descent
(AF)
are
more
likely
to
develop
PC
face
higher
mortality
compared
European
(EU).
The
biological
mechanisms
underlying
these
differences
remain
unclear.
Long
non-coding
RNAs
(lncRNAs),
recognized
as
key
regulators
gene
expression
immune
processes,
have
emerged
potential
contributors
This
study
aimed
investigate
regulatory
role
lncRNAs
localized
AF
relative
those
EU
assess
their
involvement
response
inflammation.
A
systems
biology
approach
was
employed
analyze
differentially
expressed
(DE)
roles
prostate
(PC).
Immune-related
pathways
were
investigated
through
over-representation
analysis
lncRNA-mRNA
networks.
also
examined
effects
vitamin
D
supplementation
on
lncRNA
patients,
highlighting
Key
specific
identified,
with
several
being
implicated
for
inflammatory
processes.
Notably,
10
out
top
11
ranked
demonstrated
strong
interactions
immune-related
genes.
Pathway
revealed
influence
antigen
processing
presentation,
chemokine
signaling,
ribosome
pathways,
suggesting
critical
regulation.
These
findings
highlight
pivotal
disparities,
particularly
modulation.
identified
may
serve
biomarkers
or
therapeutic
targets
address
disparities
outcomes.
Cancers,
Год журнала:
2025,
Номер
17(10), С. 1613 - 1613
Опубликована: Май 10, 2025
Renal
cell
carcinoma
(RCC)
accounts
for
about
3%
of
all
human
tumors.
Alterations
oxygen,
lipids,
iron,
and
energy
metabolism
are
involved
in
carcinogenesis,
development,
expansion.
Thirty
percent
patients
affected
by
clear
renal
(ccRCC)
will
develop
relapses
or
distance
metastases
(mRCC),
dramatically
reducing
their
life
expectancy.
Current
first-line
therapies
mRCC
based
on
treatment
with
immune
checkpoint
inhibitors
(ICIs)
alone
combination
each
other
tyrosine
kinase
(TKIs).
However,
only
20%
show
a
mild
response
because
innate
acquired
drug
resistance
during
long-term
treatment;
therefore,
resistant
need
alternative
second-line
therapies.
Pharmacological
represents
big
problem
that
counteracts
the
efficacy
overall
survival
(OS)
patients.
Investigating
molecular
mechanisms
underlying
is
crucial
to
overcoming
insensitivity
enhancing
therapeutic
outcomes.
In
this
review,
we
emphasize
latest
most
significant
studies
drive
ccRCC
carcinoma.
Particular
attention
given
key
signaling
pathways
resistance,
including
those
mediated
HIF,
p53,
Akt-mTOR,
MEK-ERK
cascades,
Wnt
signaling,
autophagy,
membrane
transporters,
ferroptosis,
non-coding
RNAs.
Understanding
these
essential
developing
new
strategies
aimed
OS
improving
quality
This
review
also
discusses
recent
clinical
trial
findings
use
specific
able
circumvent
resistance.
The
data
presented
here
could
be
valuable
clinicians
understanding
ultimately
aiding
management
Genes,
Год журнала:
2021,
Номер
12(8), С. 1154 - 1154
Опубликована: Июль 28, 2021
microRNAs
(miRNAs)
are
emerging
as
relevant
molecules
in
cancer
development
and
progression.
MiRNAs
add
a
post-transcriptional
level
of
control
to
the
regulation
gene
expression.
The
deregulation
miRNA
expression
results
changing
molecular
circuitry
which
miRNAs
involved,
leading
alterations
cell
fate
determination.
In
this
review,
we
describe
that
innovative
biomarkers
from
liquid
biopsies,
not
only
for
diagnosis,
but
also
post-surgery
management
cancer.
We
focus
our
attention
on
renal
carcinoma,
particular
highlighting
crucial
role
circulating
clear
carcinoma
(ccRCC)
management.
addition,
functional
ccRCC
is
discussed,
underline
contribution
progression,
may
be
identification
design
clinical
strategies
against
tumor.
