Frontiers in Oncology,
Journal Year:
2020,
Volume and Issue:
10
Published: Nov. 27, 2020
Objective:
The
roles
of
long
non-coding
RNAs
(lncRNAs)
in
the
diagnosis
clear
cell
renal
carcinoma
(ccRCC)
are
still
not
well-defined.
We
aimed
to
identify
differentially
expressed
lncRNAs
and
mRNAs
plasma
ccRCC
patients
health
controls
systematically.
Methods:
Expression
profile
healthy
was
analyzed
based
on
microarray
assay.
Gene
ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway-based
approaches
were
used
investigate
biological
function
signaling
pathways
mediated
by
mRNAs.
SOCS2-AS1
selected
for
validation
using
Real-Time
PCR.
further
compared
with
E-MTAB-1830
datasets
Venn
NetworkAnalyst
website.
GEPIA
ULCAN
websites
utilized
evaluation
expression
level
mRNA
their
association
overall
survival
(OS).
Results:
A
total
3,664
identified
patients,
including
1,511
up-regulated
2,153
down-regulated
(fold
change
≥2
P
<
0.05),
respectively.
There
2,268
mRNAs,
932
1,336
respectively
0.05).
Pathway
analysis
deregulated
mainly
involved
melanogenesis
Hippo
pathway
(
In
line
lncRNA
findings,
tissues,
as
well
lines.
Compared
gene
profiles,
we
18
87
differently
both
neoplastic
tissues
ccRCC.
10
EPB41L4B,
CCND1,
GGT1,
CGNL1,
CYSLTR1,
PLAUR,
UGT3A1,
PROM2,
MUC12
,
PCK1
)
correlated
(OS)
rate
websites.
Conclusions:
firstly
reported
systemically.
Several
identified,
which
might
serve
diagnostic
or
prognostic
markers.
these
should
be
validated.
Our
study
may
contribute
future
treatment
provide
novel
insights
into
cancer
biology.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(20), P. 11193 - 11193
Published: Oct. 17, 2021
The
fundamental
novelty
in
the
pathogenesis
of
renal
cell
carcinoma
(RCC)
was
discovered
as
a
result
recent
identification
role
long
non-coding
RNAs
(lncRNAs).
Here,
we
discuss
several
mechanisms
for
dysregulation
expression
protein-coding
genes
initiated
by
lncRNAs
most
common
and
aggressive
type
kidney
cancer—clear
RCC
(ccRCC).
A
model
competitive
endogenous
RNA
(ceRNA)
is
considered,
which
lncRNA
acts
on
through
lncRNA/miRNA/mRNA
axis.
For
studied
oncogenic
lncRNAs,
such
HOTAIR,
MALAT1,
TUG1,
regulatory
axes
were
identified
ccRCC,
demonstrating
number
sites
various
miRNAs.
Interestingly,
LINC00973/miR-7109/Siglec-15
axis
represents
novel
agent
that
can
suppress
immune
response
patients
with
serving
valuable
target
addition
to
PD1/PD-L1
pathway.
Other
action
involving
direct
binding
proteins,
mRNAs,
genes/DNA,
are
also
considered.
Our
review
briefly
highlights
methods
verified.
We
pay
special
attention
protein
targets
signaling
pathways
associated
ccRCC.
Thus,
these
new
data
different
functioning
provide
basis
understanding
ccRCC
prognostic
markers
therapy.
Acta Biochimica et Biophysica Sinica,
Journal Year:
2023,
Volume and Issue:
55(5), P. 726 - 735
Published: April 7, 2023
Colorectal
cancer
(CRC)
ranks
the
3rd
in
types
globally.
Long
noncoding
RNAs
(lncRNAs)
are
related
to
initiation
and
progression
of
CRC.
The
current
study
plans
reveal
action
rhabdomyosarcoma
2-associated
transcript
(RMST)
results
show
that
RMST
is
downregulated
CRC
specimens
cell
lines
relative
normal
a
fetal
colon
line
(FHC),
respectively.
Elevation
represses
proliferation
colony
formation
induces
apoptosis
cells.
Bioinformatic
analysis
reveals
binding
site
for
miR-27a-3p.
direct
association
between
miR-27a-3p
confirmed
by
dual
luciferase
reporter
assay,
RNA
pull-down
real
time-quantitative
polymerase
chain
reaction
(RT-qPCR).
upregulated
tumor
specimens,
there
negative
correlation
specimens.
In
addition,
effects
overexpression
weakened
elevation
retinoid
X
receptor
(RXRα)
share
same
complementary
with
RXRα
RT-qPCR
western
blot
analysis.
Overexpression
expression
inactivates
Wnt
signaling
pathway
decreasing
β-catenin
levels
Collectively,
our
findings
pivotal
role
regulating
miR-27a-3p/RXRα
axis
counteracting
during
Genes,
Journal Year:
2025,
Volume and Issue:
16(2), P. 229 - 229
Published: Feb. 17, 2025
Prostate
cancer
(PC)
is
the
most
common
non-cutaneous
in
men
globally,
and
one
which
displays
significant
racial
disparities.
Men
of
African
descent
(AF)
are
more
likely
to
develop
PC
face
higher
mortality
compared
European
(EU).
The
biological
mechanisms
underlying
these
differences
remain
unclear.
Long
non-coding
RNAs
(lncRNAs),
recognized
as
key
regulators
gene
expression
immune
processes,
have
emerged
potential
contributors
This
study
aimed
investigate
regulatory
role
lncRNAs
localized
AF
relative
those
EU
assess
their
involvement
response
inflammation.
A
systems
biology
approach
was
employed
analyze
differentially
expressed
(DE)
roles
prostate
(PC).
Immune-related
pathways
were
investigated
through
over-representation
analysis
lncRNA-mRNA
networks.
also
examined
effects
vitamin
D
supplementation
on
lncRNA
patients,
highlighting
Key
specific
identified,
with
several
being
implicated
for
inflammatory
processes.
Notably,
10
out
top
11
ranked
demonstrated
strong
interactions
immune-related
genes.
Pathway
revealed
influence
antigen
processing
presentation,
chemokine
signaling,
ribosome
pathways,
suggesting
critical
regulation.
These
findings
highlight
pivotal
disparities,
particularly
modulation.
identified
may
serve
biomarkers
or
therapeutic
targets
address
disparities
outcomes.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(10), P. 1613 - 1613
Published: May 10, 2025
Renal
cell
carcinoma
(RCC)
accounts
for
about
3%
of
all
human
tumors.
Alterations
oxygen,
lipids,
iron,
and
energy
metabolism
are
involved
in
carcinogenesis,
development,
expansion.
Thirty
percent
patients
affected
by
clear
renal
(ccRCC)
will
develop
relapses
or
distance
metastases
(mRCC),
dramatically
reducing
their
life
expectancy.
Current
first-line
therapies
mRCC
based
on
treatment
with
immune
checkpoint
inhibitors
(ICIs)
alone
combination
each
other
tyrosine
kinase
(TKIs).
However,
only
20%
show
a
mild
response
because
innate
acquired
drug
resistance
during
long-term
treatment;
therefore,
resistant
need
alternative
second-line
therapies.
Pharmacological
represents
big
problem
that
counteracts
the
efficacy
overall
survival
(OS)
patients.
Investigating
molecular
mechanisms
underlying
is
crucial
to
overcoming
insensitivity
enhancing
therapeutic
outcomes.
In
this
review,
we
emphasize
latest
most
significant
studies
drive
ccRCC
carcinoma.
Particular
attention
given
key
signaling
pathways
resistance,
including
those
mediated
HIF,
p53,
Akt-mTOR,
MEK–ERK
cascades,
Wnt
signaling,
autophagy,
membrane
transporters,
ferroptosis,
non-coding
RNAs.
Understanding
these
essential
developing
new
strategies
aimed
OS
improving
quality
This
review
also
discusses
recent
clinical
trial
findings
use
specific
able
circumvent
resistance.
The
data
presented
here
could
be
valuable
clinicians
understanding
ultimately
aiding
management
Cell Cycle,
Journal Year:
2022,
Volume and Issue:
21(16), P. 1710 - 1725
Published: May 3, 2022
This
study
explored
the
mechanism
that
ADAMTS9-AS2/miR-196b-5p/PPP1R12B/cell
cycle
pathway
axis
in
inhibiting
malignant
progression
of
esophageal
cancer
(EC),
providing
a
new
idea
for
targeted
molecular
therapy
EC.
The
expression
data
EC
tissue
were
acquired
from
TCGA
database.
target
lncRNA,
downstream
miRNA
and
its
gene
determined
by
bioinformatics
analysis.
ADAMTS9-AS2,
miR-196b-5p
PPP1R12B
levels
cells
assayed
through
qRT-PCR.
Western
blot
was
applied
to
assess
protein
level
tissues,
as
well
CDK1,
cyclin
A2,
B1
Plk1
cells.
Cell
proliferation
via
CCK-8
assay.
distribution
analyzed
flow
cytometry.
migratory
invasive
abilities
measured
scratch
healing
transwell
assays.
Pearson
correlation
analysis
utilized
analyze
relationship
among
PPP1R12B.
RIP
introduced
binding
three.
Dual-luciferase
assay
verify
sites.
tumor
formation
nude
mice
detect
tumorigenesis
vivo.
ADAMTS9-AS2
significantly
lowly
expressed
while
increased
bound
constrained
expression.
Overexpressed
inhibited
cell
downregulating
miR-196b-5p,
overexpressed
reversed
this
inhibitory
effect.
modulated
competitively
miR-196b-5p.
played
modulatory
role
pathway.
regulated
tumor-forming
ability
vivo
miR-196b-5p/PPP1R12B/cell
signaling
axis.
downregulated
adsorbing
so
regulate
inhibit
progression.
Genes,
Journal Year:
2021,
Volume and Issue:
12(8), P. 1154 - 1154
Published: July 28, 2021
microRNAs
(miRNAs)
are
emerging
as
relevant
molecules
in
cancer
development
and
progression.
MiRNAs
add
a
post-transcriptional
level
of
control
to
the
regulation
gene
expression.
The
deregulation
miRNA
expression
results
changing
molecular
circuitry
which
miRNAs
involved,
leading
alterations
cell
fate
determination.
In
this
review,
we
describe
that
innovative
biomarkers
from
liquid
biopsies,
not
only
for
diagnosis,
but
also
post-surgery
management
cancer.
We
focus
our
attention
on
renal
carcinoma,
particular
highlighting
crucial
role
circulating
clear
carcinoma
(ccRCC)
management.
addition,
functional
ccRCC
is
discussed,
underline
contribution
progression,
may
be
identification
design
clinical
strategies
against
tumor.
