Cell Transplantation,
Год журнала:
2020,
Номер
29, С. 096368972095309 - 096368972095309
Опубликована: Янв. 1, 2020
Accumulating
evidence
has
shown
that
long
noncoding
RNA
GAS5
is
a
well-known
tumor
suppressor
in
the
pathogenesis
of
variety
human
cancers.
However,
detailed
role
osteosarcoma
still
largely
unclear.
In
this
study,
we
found
was
downregulated
tissues
and
cell
lines
compared
with
matched
adjacent
normal
osteoblast
cells.
Overexpression
could
significantly
suppress
growth
invasion
cells,
while
downregulation
promoted
proliferation
invasion.
We
confirmed
directly
bind
miR-23a-3p
by
using
luciferase
reporter
gene
immunoprecipitation
pull-down
assay.
Downregulation
repressed
counterbalanced
inhibition
effect
on
Further
studies
indicated
overexpression
inhibited
metastasis
regulating
phosphatase
tensin
homolog
(PTEN).
PTEN
authenticated
as
target
miR-23a-3p.
Upregulation
or
silence
increased
level
PTEN,
suppressed
expression
PTEN.
addition,
neutralize
downregulating
functions.
proved
regulated
viability
cells
through
PI3K/AKT
pathway.
Moreover,
inhibit
xenograft
nude
mouse
model
vivo.
summary,
functions
competing
endogenous
RNA,
sponging
miR-23a-3p,
to
promote
Hypertension,
Год журнала:
2020,
Номер
76(4), С. 1069 - 1075
Опубликована: Авг. 31, 2020
Kidney
diseases
secondary
to
several
pathogeneses
affect
millions
of
people
worldwide
and
have
become
increasingly
recognized
as
a
global
public
health
problem.
Recent
evidence
suggests
that
cellular
senescence
plays
an
important
role
in
the
pathogenesis
different
forms
renal
damage,
including
acute
chronic
kidney
disease,
transplantation.
Renal
involves
cell
cycle
arrest
affects
pathways,
manifesting
downregulation
klotho,
elevated
expression
cyclin-dependent
kinase
inhibitors,
telomere
shortening,
oxidative
stress.
Furthermore,
senescent
cells
might
induce
injury
by
paracrine
release
inflammatory
factors.
Yet,
may
be
renoprotective
during
development
some
models
diseases,
reflecting
yin/yang
duality
senescence.
This
review
provides
overview
this
emerging
player
injury,
with
emphasis
on
new
findings
Frontiers in Pharmacology,
Год журнала:
2021,
Номер
11
Опубликована: Янв. 26, 2021
Diabetic
kidney
disease
(DKD)
is
the
most
common
diabetic
complication
and
a
leading
cause
of
end-stage
disease.
Increasing
evidence
shows
that
DKD
regulated
not
only
by
many
classical
signaling
pathways
but
also
epigenetic
mechanisms
involving
chromatin
histone
modifications,
DNA
methylation,
non-coding
RNA
(ncRNAs).
In
this
review,
we
focus
on
our
current
understanding
role
ncRNAs,
including
microRNAs
(miRNAs)
long
RNAs
(lncRNAs)
in
pathogenesis
DKD.
Of
them,
regulatory
TGF-β/Smad3-dependent
miRNAs
lncRNAs
highlighted.
Importantly,
as
biomarkers
therapeutic
targets
for
are
described,
perspective
ncRNAs
novel
approach
combating
nephropathy
discussed.
Frontiers in Pharmacology,
Год журнала:
2021,
Номер
12
Опубликована: Апрель 29, 2021
Long
noncoding
RNA
(lncRNAs)
metastasis-associated
lung
adenocarcinoma
transcript
1
(MALAT1)
has
been
reported
in
diabetic
nephropathy
(DN)
about
its
effect
on
podocyte
function
and
cell
heat
shock
induced
by
hyperglycemia.
However,
the
biological
mechanism
of
MALAT1
regulating
DN
fibrosis
needs
further
study.
In
this
study,
SD
rats
were
administrated
with
streptozotocin
(STZ)
to
establish
a
diabetes
model.
Life,
Год журнала:
2022,
Номер
12(2), С. 274 - 274
Опубликована: Фев. 12, 2022
Diabetes
mellitus
is
a
well-known
metabolic
disorder
with
numerous
complications,
such
as
macrovascular
diseases
(e.g.,
coronary
heart
disease,
diabetic
cardiomyopathy,
stroke,
and
peripheral
vascular
disease),
microvascular
nephropathy,
retinopathy,
cataract),
neuropathy.
Multiple
contributing
factors
are
implicated
in
these
the
accumulation
of
oxidative
stress
one
critical
ones.
Several
lines
evidence
have
suggested
that
may
induce
epigenetic
modifications
eventually
contribute
to
complications.
As
kind
regulator
involved
various
disorders,
non-coding
RNAs
received
great
attention
over
past
few
years.
Non-coding
can
be
roughly
divided
into
short
(such
microRNAs;
~21–25
nucleotides)
or
long
(lncRNAs;
>200
nucleotides).
In
this
review,
we
briefly
discussed
research
regarding
roles
lncRNAs,
MALAT1,
MEG3,
GAS5,
SNHG16,
CASC2,
HOTAIR,
development
complications
response
stimulation
stress.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
160, С. 114361 - 114361
Опубликована: Фев. 6, 2023
Non-coding
RNA
(ncRNA)
is
a
special
type
of
transcript
that
makes
up
more
than
90
%
the
human
genome.
Although
ncRNA
typically
does
not
encode
proteins,
it
indirectly
controls
wide
range
biological
processes,
including
cellular
metabolism,
development,
proliferation,
transcription,
and
post-transcriptional
modification.
NcRNAs
include
small
interfering
(siRNA),
PIWI-interacting
(piRNA),
tRNA-derived
(tsRNA),
etc.
The
most
researched
these
are
miRNA,
lncRNA,
circRNA,
which
crucial
regulators
in
onset
diabetes
development
associated
consequences.
ncRNAs
indicated
above
linked
to
numerous
problems
by
binding
diabetic
foot
(DF),
nephropathy,
cardiomyopathy,
peripheral
neuropathy.
According
recent
studies,
Mir-146a
can
control
AKAP12
axis
promote
proliferation
migration
ulcer
(DFU)
cells,
while
lncRNA
GAS5
activate
HIF1A/VEGF
pathway
TAF15
DFU
wound
healing.
However,
there
still
many
unanswered
questions
about
mechanism
action
ncRNAs.
In
this
study,
we
explored
new
progress
ncRNA-protein
DF,
provide
help
guidance
for
application
early
diagnosis
potential
targeted
intervention
DFU.
Journal of Cellular and Molecular Medicine,
Год журнала:
2021,
Номер
25(11), С. 4922 - 4937
Опубликована: Май 3, 2021
Abstract
Long
non‐coding
RNA
(lncRNA)
lnc‐ISG20
has
been
found
aberrantly
up‐regulated
in
the
glomerular
patients
with
diabetic
nephropathy
(DN).
We
aimed
to
elucidate
function
and
regulatory
mechanism
of
lncRNA
on
DN‐induced
renal
fibrosis.
Expression
patterns
kidney
tissues
DN
were
determined
by
RT‐qPCR.
Mouse
models
constructed,
while
MCs
cultured
under
normal
glucose
(NG)/high
(HG)
conditions.
The
expression
fibrosis
marker
proteins
collagen
IV,
fibronectin
TGF‐β1
measured
Western
blot
assay.
In
addition,
relationship
among
lnc‐ISG20,
miR‐486‐5p,
NFAT5
AKT
analysed
using
dual‐luciferase
reporter
assay
immunoprecipitation.
effect
miR‐486/NFAT5/p‐AKT
axis
DN‐associated
was
also
verified
means
rescue
experiments.
levels
increased
patients,
mouse
HG‐treated
MCs.
Lnc‐ISG20
silencing
alleviated
HG‐induced
delayed
mice.
Mechanistically,
miR‐486‐5p
be
a
downstream
miRNA
inhibited
binding
its
3'UTR.
overexpression
aggravated
stimulating
phosphorylation.
However,
reversed
promotion
vitro
vivo
caused
overexpression.
Our
collective
findings
indicate
that
promotes
process
activating
through
miR‐486‐5p/NFAT5
axis.
High‐expression
may
useful
indicator
for
DN.
Frontiers in Aging Neuroscience,
Год журнала:
2021,
Номер
13
Опубликована: Сен. 20, 2021
The
intracellular
energy
state
will
alter
under
the
influence
of
physiological
or
pathological
stimuli.
In
response
to
this
change,
cells
usually
mobilize
various
molecules
and
their
mechanisms
promote
stability
status.
Mitochondria
are
main
source
ATP.
Previous
studies
have
found
that
function
mitochondria
is
impaired
in
aging,
neurodegenerative
diseases,
metabolic
damaged
bring
lower
ATP
production,
which
further
worsens
progression
disease.
Silent
information
regulator-1
(SIRT1)
a
multipotent
molecule
participates
regulation
important
biological
processes
cells,
including
cellular
metabolism,
cell
senescence,
inflammation.
review,
we
mainly
discuss
promoting
expression
activity
SIRT1
contributes
alleviating
stress
produced
by
conditions.
review
also
discusses
mechanism
precise
dimensions.
Finally,
according
characteristics
recovery
mitochondrial
function,
relationship
between
current
pharmacological
preparations
other
diseases
was
analyzed.
