Exosomal hsa_circ_0125310 promotes cell proliferation and fibrosis in diabetic nephropathy via sponging miR‐422a and targeting the IGF1R/p38 axis DOI
Yingchun Zhu,

Fangfang Zha,

Bo Tang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2021, Volume and Issue: 26(1), P. 151 - 162

Published: Dec. 2, 2021

Abstract Diabetic nephropathy (DN) is still on the rise worldwide, and millions of patients have to be treated through dialysis or transplant because kidney failure caused by DN. Recent reports highlighted circRNAs in treatment Herein, we aimed investigate mechanism which high glucose‐induced exo‐circ_0125310 promotes diabetic progression. circ_0125310 highly expressed exosomes isolated from mesangial cells (MCs). High promote proliferation fibrosis MCs. However, results showed that effects MCs can reversed knockdown circ_0125310. miR‐422a, targets IGF1R, was direct target regulated IGF1R/p38 axis sponging miR‐422a. Exo‐circ_0125310 increased luciferase activity WT‐IGF1R reporter dual‐luciferase gene assays upregulated expression level IGF1R p38. Finally, vivo research indicated overexpression promoted Above demonstrated cell via miR‐422a targeting axis.

Language: Английский

Podocyte-derived extracellular vesicles mediate renal proximal tubule cells dedifferentiation via microRNA-221 in diabetic nephropathy DOI

Hong Su,

Jiao Qiao,

Jinxiu Hu

et al.

Molecular and Cellular Endocrinology, Journal Year: 2020, Volume and Issue: 518, P. 111034 - 111034

Published: Sept. 12, 2020

Language: Английский

Citations

46
Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease DOI Creative Commons
Yue-Yu Gu, Fuhua Lu,

Xiao‐Ru Huang

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 26, 2021

Diabetic kidney disease (DKD) is the most common diabetic complication and a leading cause of end-stage disease. Increasing evidence shows that DKD regulated not only by many classical signaling pathways but also epigenetic mechanisms involving chromatin histone modifications, DNA methylation, non-coding RNA (ncRNAs). In this review, we focus on our current understanding role ncRNAs, including microRNAs (miRNAs) long RNAs (lncRNAs) in pathogenesis DKD. Of them, regulatory TGF-β/Smad3-dependent miRNAs lncRNAs highlighted. Importantly, as biomarkers therapeutic targets for are described, perspective ncRNAs novel approach combating nephropathy discussed.

Language: Английский

Citations

41
lncRNA MALAT1 Promotes Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-2355-3p/IL6ST Axis DOI Creative Commons

Haozi Huang,

Guowei Zhang, Zhenying Ge

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: April 29, 2021

Long noncoding RNA (lncRNAs) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been reported in diabetic nephropathy (DN) about its effect on podocyte function and cell heat shock induced by hyperglycemia. However, the biological mechanism of MALAT1 regulating DN fibrosis needs further study. In this study, SD rats were administrated with streptozotocin (STZ) to establish a diabetes model.

Language: Английский

Citations

41
Cellular Senescence DOI Open Access
Yong‐Xin Li, Lilach O. Lerman

Hypertension, Journal Year: 2020, Volume and Issue: 76(4), P. 1069 - 1075

Published: Aug. 31, 2020

Kidney diseases secondary to several pathogeneses affect millions of people worldwide and have become increasingly recognized as a global public health problem. Recent evidence suggests that cellular senescence plays an important role in the pathogenesis different forms renal damage, including acute chronic kidney disease, transplantation. Renal involves cell cycle arrest affects pathways, manifesting downregulation klotho, elevated expression cyclin-dependent kinase inhibitors, telomere shortening, oxidative stress. Furthermore, senescent cells might induce injury by paracrine release inflammatory factors. Yet, may be renoprotective during development some models diseases, reflecting yin/yang duality senescence. This review provides overview this emerging player injury, with emphasis on new findings

Language: Английский

Citations

40
LncRNA lnc‐ISG20 promotes renal fibrosis in diabetic nephropathy by inducing AKT phosphorylation through miR‐486‐5p/NFAT5 DOI

Yurui Duan,

Bao‐Ping Chen,

Fang Chen

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2021, Volume and Issue: 25(11), P. 4922 - 4937

Published: May 3, 2021

Abstract Long non‐coding RNA (lncRNA) lnc‐ISG20 has been found aberrantly up‐regulated in the glomerular patients with diabetic nephropathy (DN). We aimed to elucidate function and regulatory mechanism of lncRNA on DN‐induced renal fibrosis. Expression patterns kidney tissues DN were determined by RT‐qPCR. Mouse models constructed, while MCs cultured under normal glucose (NG)/high (HG) conditions. The expression fibrosis marker proteins collagen IV, fibronectin TGF‐β1 measured Western blot assay. In addition, relationship among lnc‐ISG20, miR‐486‐5p, NFAT5 AKT analysed using dual‐luciferase reporter assay immunoprecipitation. effect miR‐486/NFAT5/p‐AKT axis DN‐associated was also verified means rescue experiments. levels increased patients, mouse HG‐treated MCs. Lnc‐ISG20 silencing alleviated HG‐induced delayed mice. Mechanistically, miR‐486‐5p be a downstream miRNA inhibited binding its 3'UTR. overexpression aggravated stimulating phosphorylation. However, reversed promotion vitro vivo caused overexpression. Our collective findings indicate that promotes process activating through miR‐486‐5p/NFAT5 axis. High‐expression may useful indicator for DN.

Language: Английский

Citations

33
Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node DOI Creative Commons
Fang Yang, Xifeng Wang,

Danying Yang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: Sept. 20, 2021

The intracellular energy state will alter under the influence of physiological or pathological stimuli. In response to this change, cells usually mobilize various molecules and their mechanisms promote stability status. Mitochondria are main source ATP. Previous studies have found that function mitochondria is impaired in aging, neurodegenerative diseases, metabolic damaged bring lower ATP production, which further worsens progression disease. Silent information regulator-1 (SIRT1) a multipotent molecule participates regulation important biological processes cells, including cellular metabolism, cell senescence, inflammation. review, we mainly discuss promoting expression activity SIRT1 contributes alleviating stress produced by conditions. review also discusses mechanism precise dimensions. Finally, according characteristics recovery mitochondrial function, relationship between current pharmacological preparations other diseases was analyzed.

Language: Английский

Citations

33
Regulation of Oxidative Stress by Long Non-Coding RNAs in Vascular Complications of Diabetes DOI Creative Commons

Pei‐Ming Chu,

Cheng‐Chia Yu, Kun‐Ling Tsai

et al.

Life, Journal Year: 2022, Volume and Issue: 12(2), P. 274 - 274

Published: Feb. 12, 2022

Diabetes mellitus is a well-known metabolic disorder with numerous complications, such as macrovascular diseases (e.g., coronary heart disease, diabetic cardiomyopathy, stroke, and peripheral vascular disease), microvascular nephropathy, retinopathy, cataract), neuropathy. Multiple contributing factors are implicated in these the accumulation of oxidative stress one critical ones. Several lines evidence have suggested that may induce epigenetic modifications eventually contribute to complications. As kind regulator involved various disorders, non-coding RNAs received great attention over past few years. Non-coding can be roughly divided into short (such microRNAs; ~21–25 nucleotides) or long (lncRNAs; >200 nucleotides). In this review, we briefly discussed research regarding roles lncRNAs, MALAT1, MEG3, GAS5, SNHG16, CASC2, HOTAIR, development complications response stimulation stress.

Language: Английский

Citations

26
lncRNA TUG1 promotes endometrial fibrosis and inflammation by sponging miR-590-5p to regulate Fasl in intrauterine adhesions DOI

Ying Ai,

Mingqing Chen, Jia Liu

et al.

International Immunopharmacology, Journal Year: 2020, Volume and Issue: 86, P. 106703 - 106703

Published: June 26, 2020

Language: Английский

Citations

35
RETRACTED: Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation DOI
Ziyuan Guo,

Zhuo Zhao,

Chuang Yang

et al.

Translational research, Journal Year: 2020, Volume and Issue: 226, P. 83 - 95

Published: July 10, 2020

Language: Английский

Citations

35
The long intergenic noncoding RNA GAS5 reduces cisplatin-resistance in non-small cell lung cancer through the miR-217/LHPP axis DOI Creative Commons
Xuhui Yang, Lifei Meng,

Yuang Zhong

et al.

Aging, Journal Year: 2021, Volume and Issue: 13(2), P. 2864 - 2884

Published: Jan. 8, 2021

Long noncoding RNAs (lncRNAs) are known to exert their effects tumor progression. In this study, the role of lncRNA GAS5 (growth arrest specific 5) was confirmed in reducing non-small cell lung cancer (NSCLC) cisplatin (DDP) resistance. NSCLC tissue samples, expression decreased significantly. Low levels were positively correlated with characteristics including TNM, size and lymphatic metastasis. Functionally, significantly reduced NSCLC/DDP migration, invasion epithelial-mesenchymal transition (EMT) progression vitro. vivo, upregulation inhibited remarkably growth. Mechanism analysis suggested that a molecular sponge miR-217, inhibiting phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP). conclusion, study reveals GAS5/miR-217/LHPP pathway reduces resistance LHPP may serve as potential therapeutic target for

Language: Английский

Citations

31