ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

Cell Reports, Год журнала: 2023, Номер 42(7), С. 112779 - 112779

Опубликована: Июль 1, 2023

Retinal pigment epithelium (RPE) dysfunction and choroidal neovascularization (CNV) are predominant features of age-related macular degeneration (AMD), with an unclear mechanism. Herein, we show that RNA demethylase α-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5) is up-regulated in AMD. In RPE cells, ALKBH5 overexpression associates depolarization, oxidative stress, disturbed autophagy, irregular lipid homeostasis, elevated VEGF-A secretion, which subsequently promotes proliferation, migration, tube formation vascular endothelial cells. Consistently, mice correlates various pathological phenotypes, including visual impairments, anomalies, (CNV), interrupted retinal homeostasis. Mechanistically, regulates through its demethylation activity. It targets PIK3C2B the AKT/mTOR signaling pathway YTHDF2 as N6-methyladenosine reader. IOX1, inhibitor, suppresses hypoxia-induced CNV progression. Collectively, demonstrate induces progression AMD via PIK3C2B-mediated activation pathway. Pharmacological inhibitors ALKBH5, like promising therapeutic options for

Язык: Английский

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Role of m6A methylation in retinal diseases

Experimental Eye Research, Год журнала: 2023, Номер 231, С. 109489 - 109489

Опубликована: Апрель 20, 2023

Язык: Английский

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Regulation of inflammatory response by LINC00346 via miR-25-3p-mediated modulation of the PTEN/PI3K/AKT/NF-κB pathway

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 709, С. 149828 - 149828

Опубликована: Март 25, 2024

Язык: Английский

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Methyltransferase-like 3 modifications of RNAs: Implications for the pathology in the endocrine system

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(3), С. 167010 - 167010

Опубликована: Янв. 2, 2024

Язык: Английский

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The role of m6A modification in type 2 diabetes: A systematic review and integrative analysis

Gene, Год журнала: 2024, Номер 898, С. 148130 - 148130

Опубликована: Янв. 3, 2024

Язык: Английский

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