Frontiers in Aging, Год журнала: 2024, Номер 5
Опубликована: Окт. 9, 2024
Normal cells divide, are damaged, and repaired across their lifetime. As age, they enter cellular senescence, characterized by a permanent state of cell-cycle arrest triggered various stressors. The molecular mechanisms that regulate senescent phenotypes have been actively investigated over the last several decades; however, one area has neglected is how G-quadruplex (G4) DNA RNA (G4-DNA G4-RNA) mediate senescence. These non-canonical four-stranded structures most normative RNA-dependent processes, such as transcription, replication, translation, well pathogenic mechanisms, including genomic instability abnormal stress granule function. This review also highlights contribution G4s to sex differences in age-associated diseases emphasizes potential translational approaches target senescence anti-aging through G4 manipulation.
Язык: Английский
Процитировано
0Dedication
Oxford University Press eBooks, Год журнала: 2024, Номер unknown, С. v - vi
Опубликована: Окт. 24, 2024
Процитировано
0Looking for Sowbugs
Oxford University Press eBooks, Год журнала: 2024, Номер unknown, С. 1 - 11
Опубликована: Окт. 24, 2024
Abstract Most people in the developed world pay little attention to biology and nature. Humans live a sheltered existence. When they do “interact” with nature, it is typically at zoo or park breathtakingly beautiful movies television series. The setting nearly always an exotic location (e.g., Kalahari Desert, Antarctic), subconsciously reinforcing concept that happens somewhere else. Yet, humans are animals too, still part of natural world. Nature all around on them. Psychologists have noted benefits interacting E.O. Wilson referred as “biophilia.” Increasing appreciation our place nature desirable goal.
Язык: Английский
Процитировано
0Telling Time
Oxford University Press eBooks, Год журнала: 2024, Номер unknown, С. 249 - 261
Опубликована: Окт. 24, 2024
Abstract Many physiological processes in humans, other animals, and even some bacteria obey a regular pattern based on 24-hour solar day. These circadian rhythms are the most obvious way humans “tell time.” They controlled by molecular clocks genes cells suprachiasmatic nucleus brains. Those can be thrown off jet lag, daylight savings time, external influences. However, there also clocks, such as hormonal cycles sleep phases. For example, human development involves complex programs of genetic pathways that must turned or at proper times, aging many unanswered questions. Animals respond to lunar, seasonal, clocks.
Язык: Английский
Процитировано
0Tides of the Body
Опубликована: Окт. 24, 2024
Язык: Английский
Процитировано
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