G-quadruplex DNA and RNA in cellular senescence

Frontiers in Aging, Journal Year: 2024, Volume and Issue: 5

Published: Oct. 9, 2024

Normal cells divide, are damaged, and repaired across their lifetime. As age, they enter cellular senescence, characterized by a permanent state of cell-cycle arrest triggered various stressors. The molecular mechanisms that regulate senescent phenotypes have been actively investigated over the last several decades; however, one area has neglected is how G-quadruplex (G4) DNA RNA (G4-DNA G4-RNA) mediate senescence. These non-canonical four-stranded structures most normative RNA-dependent processes, such as transcription, replication, translation, well pathogenic mechanisms, including genomic instability abnormal stress granule function. This review also highlights contribution G4s to sex differences in age-associated diseases emphasizes potential translational approaches target senescence anti-aging through G4 manipulation.

Language: Английский

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Dedication

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown, P. v - vi

Published: Oct. 24, 2024

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Looking for Sowbugs

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Oct. 24, 2024

Abstract Most people in the developed world pay little attention to biology and nature. Humans live a sheltered existence. When they do “interact” with nature, it is typically at zoo or park breathtakingly beautiful movies television series. The setting nearly always an exotic location (e.g., Kalahari Desert, Antarctic), subconsciously reinforcing concept that happens somewhere else. Yet, humans are animals too, still part of natural world. Nature all around on them. Psychologists have noted benefits interacting E.O. Wilson referred as “biophilia.” Increasing appreciation our place nature desirable goal.

Language: Английский

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Telling Time

Oxford University Press eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 249 - 261

Published: Oct. 24, 2024

Abstract Many physiological processes in humans, other animals, and even some bacteria obey a regular pattern based on 24-hour solar day. These circadian rhythms are the most obvious way humans “tell time.” They controlled by molecular clocks genes cells suprachiasmatic nucleus brains. Those can be thrown off jet lag, daylight savings time, external influences. However, there also clocks, such as hormonal cycles sleep phases. For example, human development involves complex programs of genetic pathways that must turned or at proper times, aging many unanswered questions. Animals respond to lunar, seasonal, clocks.

Language: Английский

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Tides of the Body

Published: Oct. 24, 2024

Language: Английский

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