Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 1, 2024
Abstract
This
investigation
elucidates
the
genetic
connection
between
major
depressive
disorder
(MD)
and
metabolic
syndrome
(MetS),
uncovering
bidirectional
interactions
shared
pleiotropic
genes.
Leveraging
a
comprehensive
genome-wide
association
study
(GWAS)
dataset
from
European
East
Asian
populations,
we
discovered
new
markers
linked
to
MD
enhanced
robustness
of
associations
via
cross-trait
analysis.
Moreover,
harnessed
computational
strategies
for
drug
repurposing,
highlighting
potential
Cytochrome
P450
HDAC
inhibitors
as
novel
treatments
MetS.
Employing
BLISS
technology,
pinpointed
proteins
significantly
both
conditions,
advancing
our
comprehension
their
molecular
underpinnings.
Through
Mendelian
randomization,
investigated
how
diverse
dietary
patterns
across
populations
influence
MetS,
shedding
light
on
relationship
diet
disease
susceptibility.
research
not
only
enriches
understanding
intersecting
biological
pathways
MetS
but
also
opens
avenues
innovative
preventive
therapeutic
measures.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4511 - 4511
Опубликована: Апрель 20, 2024
Major
depressive
disorder
is
a
severe
mood
associated
with
marked
decrease
in
quality
of
life
and
social
functioning,
accompanied
by
risk
suicidal
behavior.
Therefore,
seeking
out
adhering
to
effective
treatment
great
personal
society-wide
importance.
Weight
changes
antidepressant
therapy
are
often
cited
as
the
reason
for
withdrawal
thus
an
important
topic
interest.
There
indeed
exists
significant
mechanistic
overlap
between
depression,
treatment,
regulation
appetite
body
weight.
The
suggested
pathomechanisms
include
abnormal
functioning
homeostatic
(mostly
humoral)
hedonic
dopaminergic)
circuits
regulation,
well
causing
neuromorphological
neurophysiological
underlying
development
disorder.
However,
this
issue
still
extensively
discussed.
This
review
aims
summarize
mechanisms
linked
depression
context
weight
change.
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 10, 2025
While
the
physical
health
effects
of
obesity
are
well-characterized,
an
emerging
branch
research
has
shown
that
additionally
plays
a
critical
role
in
one's
mental
health.
Young
adults,
pivotal
transition
phase
their
lives,
may
be
particularly
prone
to
concurrent
and
adverse
outcomes.
The
purpose
this
review
is
comprehensively
examine
existing
data
regarding
connection
between
two
widely
validated
measures
health:
psychological
distress
depression.
outcomes
mediated
by
complex
interplay
biological
sociocultural
factors,
which
explored
with
particular
focus
on
younger
adults
aged
20-39.
Further,
impact
several
demographic
factors
including
race/ethnicity,
gender,
immigration
status
examined
closely.
To
our
knowledge,
one
first
efforts
integrate
knowledge
health,
regard
for
young
other
key
sociodemographic
characteristics.
This
important
implications
at
interface
most
pressing
public
crises
United
States.
Biomolecules,
Год журнала:
2025,
Номер
15(3), С. 408 - 408
Опубликована: Март 13, 2025
Worldwide,
nearly
40%
of
adults
are
overweight
and
13%
obese.
Health
consequences
excess
weight
include
cardiovascular
diseases,
type
2
diabetes,
dyslipidemia,
increased
mortality.
Treating
obesity
is
challenging
calorie
restriction
often
leads
to
rebound
gain.
Treatments
such
as
bariatric
surgery
create
hesitancy
among
patients
due
their
invasiveness.
GLP-1
medications
have
revolutionized
loss
can
reduce
body
in
obese
by
between
15%
25%
on
average
after
about
1
year.
Their
mode
action
mimic
the
endogenous
GLP-1,
an
intestinal
hormone
that
regulates
glucose
metabolism
satiety.
However,
drugs
carry
known
risks
and,
since
use
for
recent,
may
unforeseen
well.
They
a
boxed
warning
people
with
personal
or
family
history
medullary
thyroid
carcinoma
multiple
endocrine
neoplasia
syndrome
2.
Gastrointestinal
adverse
events
(nausea,
vomiting,
diarrhea)
fairly
common
while
pancreatitis
obstruction
rarer.
There
be
lean
mass
well
premature
facial
aging.
A
significant
disadvantage
using
these
high
rate
regain
when
they
discontinued.
Achieving
success
pharmacologic
treatment
then
weaning
avoid
future
negative
effects
would
ideal.
Journal of Affective Disorders,
Год журнала:
2024,
Номер
365, С. 313 - 320
Опубликована: Авг. 13, 2024
In
recent
years,
several
studies
have
suggested
that
obesity
may
play
an
important
role
in
cognitive
impairment.
Individuals
with
impairment
often
also
exhibit
depressive
symptoms.
This
study
aimed
to
explore
the
association
between
and
elucidate
mediating
of
symptoms
this
association.
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 1994 - 1994
Опубликована: Сен. 2, 2024
Depression
affects
several
aspects
of
life,
including
socioeconomic
status,
relationships,
behavior,
emotions,
and
overall
health.
The
etiology
depression
is
complex
influenced
by
various
factors,
with
obesity
emerging
as
a
significant
contributor.
This
narrative
review
aims
to
investigate
the
factors
associated
development
depression,
particular
focus
on
role
obesity.
literature
search
was
conducted
PubMed,
Embase,
PsycINFO
from
May
July
2024.
highlights
impact
environmental
conditions;
lifestyle
choices,
physical
activity
dietary
habits;
stress;
traumatic
experiences;
neurotransmitter
imbalances;
medical
psychological
hormone
fluctuations;
epigenetic
depression.
A
key
emphasis
placed
inflammatory
processes
linked
obesity,
which
may
drive
bidirectional
relationship
between
findings
suggest
that
an
increased
risk
potentially
due
chronic
inflammation,
neurochemical
dysregulation,
emotional
social
challenges
related
weight
stigma
management.
Understanding
these
interconnected
important
for
developing
targeted
interventions
address
both
leading
improved
quality
life
those
affected.
Heliyon,
Год журнала:
2024,
Номер
10(7), С. e28782 - e28782
Опубликована: Апрель 1, 2024
BackgroundPatients
with
type
2
diabetes
have
a
nearly
twofold
higher
rate
of
diagnosed
mental
disorders
than
those
without
diabetes.
The
association
between
and
is
well
established
in
the
literature
recognized
as
bidirectional
relationship.
This
study
aims
to
conduct
an
umbrella
review
risk
protective
factors
for
health
patients
assess
credibility
evidence
each
factor
disorders.MethodsA
comprehensive
search
was
conducted
Medline
via
PubMed,
Web
Science,
EMBASE,
CINHAL,
PsycINFO
from
inception
November
17,
2022,
identify
systematic
reviews
meta-analyses
examining
associations
For
association,
we
recalculated
summary
effect
size
95%
confidence
intervals
using
random-effects
models.
We
also
reported
prediction
interval
between-group
heterogeneity.ResultsThe
included
11
that
met
inclusion
criteria,
comprising
eight
three
meta-analyses.
involved
approximately
489,930
participants
encompassed
26
unique
factors.
Six
were
rated
having
suggestive
at
Class
III
level.
These
obesity
(n
=
18,456,
OR
1.75
[1.2
2.59],
I2
97.7%),
neuropathy
3898,
2.01
[1.60
2.54],
44.5%),
complications
1769,
1.90
[1.53
2.36],
39.3%),
peripheral
blood
concentrations
CRP
1742,
SMD
0.31
[0.16
0.45],
84.1%),
female
sex
35,162,
1.36
[1.19
1.54],
64.5%),
social
support
3151,
2.02
[1.51
2.70],
87.2%).ConclusionsSeveral
associated
identified
varying
degrees
supporting
evidence.
Significantly,
obesity,
neuropathy,
complications,
concentrations,
sex,
emerged
An
investigation
these
should
be
target
interventions
accordingly.
It
may
helpful
prioritize
who
high-risk
groups
implement
plans
policies
enhance
before
occur.
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 29, 2025
Attention
Deficit
Hyperactivity
Disorder
(ADHD)
is
a
clinically
common
neurodevelopmental
disorder
of
the
brain.
In
addition
to
genetic
factors,
an
imbalance
in
gut
flora
may
also
play
role
development
ADHD.
Currently,
it
critical
investigate
function
and
related
metabolites,
which
form
fundamental
basis
bidirectional
cross-linking
between
brain
gut,
focusing
on
changed
This
study
aimed
possible
relationship
changes
metabolites
ADHD
by
analyzing
metagenome
untargeted
metabolomics
fecal
samples
from
patients.
Specifically,
we
attempted
identify
key
metabolic
pathways
they
are
involved
in,
as
well
analyze
detail
structure
composition
order
further
symptoms,
some
behavioral
studies
were
conducted
following
transplantation
patients
into
rats.
The
results
analysis
revealed
several
distinct
strains,
including
Bacteroides
cellulosilyticus
,
could
be
important
for
diagnosing
Additionally,
group
showed
modifications
nicotinamide
nicotinic
acid
metabolite
this
pathway.
demonstrated
that
rats
with
transplants
displayed
increased
locomotor
activity
interest,
indicating
onset
behaviors
such
facilitated
associated
research
verified
alterations
metabolism
observed
provided
list
significantly
altered
Simultaneously,
our
findings
microbiome
potentially
trigger
animals,
providing
experimental
comprehending
influence
These
might
provide
new
perspectives
novel
treatment
strategies.
Obesity
is
a
major
global
public
health
challenge
affecting
all
countries
and
communities.
The
link
between
obesity
various
types
of
physical
morbidities
has
been
widely
acknowledged
in
different
studies.
Despite
the
immense
impact
on
mental
health,
its
full
effect
areas
not
as
explored
been.
Following
an
extensive
review
recent
studies,
objective
this
study
to
evaluate
correlations
effects
disorders,
addition
reflecting
significance
assessing
correlation.
other
prevalence
mentally
ill
individuals.
We
believe
that
realization
these
objectives
will
address
existing
literature
gaps
within
population
persons
aiding
with
necessary
preventive
knowledge
enable
provision
optimum
health.
Therefore,
entailed
performance
systematic
several
online
databases,
including
Scopus,
Web
Sciences,
PubMed,
Google
Scholar,
MEDLINE.
This
also
utilized
increasingly
robust
methodology
based
Cochrane
guidelines
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
(PRISMA)
guidelines.
Thus,
inclusion
criteria
stipulated
only
studies
published
2010
2024
English
language
were
be
included
review.
quality
was
assessed
using
appraisal
tool
cross-sectional
As
result,
12
met
reviewed.
findings
indicate
rate
individuals
disorders
surpasses
condition
general
population,
suggesting
are
at
higher
risk
developing
obesity,
even
one
side
psychiatric
treatment
excessive
weight
gain.
Individuals
personality
borderline
disorder,
avoidant
dependent
antisocial
among
others,
presented
highest
compared
those
psychosis.
Prospective
should
focus
evaluating
mitigating
factors
underlie
gain
development
occur
across
disorders.
Several
studies
have
indicated
a
potential
association
between
obesity,
depression,
and
sleep
disorders.
However,
the
role
of
depression
in
mediating
relationship
obesity
disorders
remains
unclear.
The
Body
Roundness
Index
(BRI),
more
precise
anthropometric
measure
than
traditional
body
mass
index
(BMI),
is
particularly
effective
assessing
visceral
fat
levels.
This
study
examines
BRI
disorders,
with
focus
on
whether
influences
this
association.
included
data
from
32,504
participants
National
Health
Nutrition
Examination
Survey
(NHANES)
2005–2018
cycle.
was
examined
through
subgroup
analysis,
restricted
cubic
spline
(RCS)
modeling,
threshold
effect
multivariable
logistic
regression.
Furthermore,
predictive
capabilities
various
indices—including
BRI,
weight-adjusted
waist
(WWI),
BMI,
weight—on
disorder
incidence
were
assessed
using
Receiver
Operating
Characteristic
(ROC)
curve
analysis.
Finally,
Mediation
analysis
also
performed
to
explore
relationship.
participants,
whom
4,568
reported
After
adjusting
for
all
covariates
regression,
each
one-unit
increase
associated
13%
higher
prevalence
(OR
=
1.13,
95%
CI:
1.09,
1.16)
an
8%
1.08,
1.05,
1.11).
Similar
results
obtained
when
divided
into
tertiles,
significant
trend
(P
<
0.05).
RCS
analyses
revealed
nonlinear
prevalence,
breakpoint
3.508.
ROC
that
had
superior
capability
compared
indices,
area
under
(AUC)
0.637
(95%
CI,
0.628–0.645,
P
0.001).
further
14%
mediated
by
Elevated
levels
linked
acting
as
partial
mediator
These
findings
emphasize
connection
highlighting
importance
managing
mitigate
risk
Not
applicable.
