Insights into mitochondrial creatine kinase: examining preventive role of creatine supplement in doxorubicin-induced cardiotoxicity DOI
Salaheddin M Sharif,

David S. Hydock

Toxicology Mechanisms and Methods, Год журнала: 2024, Номер unknown, С. 1 - 10

Опубликована: Авг. 21, 2024

Doxorubicin (Dox) is an effective and commonly used anticancer drug; however, it leads to several side effects including cardiotoxicity which contributes poor quality of life for cancer patients. Creatine (Cr) a promising intervention alleviate Dox-induced cardiotoxicity. This study aimed examine the Cr beforeDox on cardiac mitochondrial creatine kinase (MtCK). Male rats were randomly assigned one two 4-week feeding interventions (standard diet or loading diet) control (Con, n = 20). Rats in standard (Cr1, 20) fed 2% 4-weeks. (Cr2, 4% 1-week followed by 3-weeks. After 4-weeks, received either bolus injection 15 mg/kg Dox placebo saline (Sal). Five days post-injections left ventricle (LV) was excised analyzed MtCK expression using Western blot ELISA. A significant drug effect observed LV mass (p < 0.05), post hoc testing revealed Con + Cr2 significantly lower than Sal 0.05). 0.03) through blot. interaction 0.02) Post that had higher Cr1 Sal. Data suggest reduction may contribute cardiotoxicity, supplementation play potential role mitigating preserving CK.

Язык: Английский

The role of cardiomyocyte senescence in cardiovascular diseases: a molecular biology update DOI

Shuang-Yi He,

Yan Li, Chao Yuan

и другие.

European Journal of Pharmacology, Год журнала: 2024, Номер 983, С. 176961 - 176961

Опубликована: Авг. 28, 2024

Язык: Английский

Процитировано

7
Oxidative stress and cell senescence as drivers of ageing: chicken and egg DOI
Thomas von Zglinicki

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102558 - 102558

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

3
Spermine alleviates myocardial cell aging by inhibiting mitochondrial oxidative stress damage DOI

Jing Yang,

Chunrui Zhang, Zixuan Li

и другие.

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177477 - 177477

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
AMD1, a cardiotoxicity target for Maduramicin DOI Creative Commons
Z. P. Xie, Haiqing Liu, Jie Zhao

и другие.

BMC Pharmacology and Toxicology, Год журнала: 2025, Номер 26(1)

Опубликована: Март 11, 2025

The aim of this study was to investigate AMD1 cardiotoxicity function for Maduramicin (Mad). SD rats were divided into control (Control) group and Mad treatment (3.5 mg/kg) After with seven days, the levels LDH CK-MB in serum detected, H&E staining TUNEL performed. In vitro, 1.0 μm used subsequently experiment, observing cell apoptosis from Flow cytometry. Caspase-3 detected Western blotting. cytometry blotting also performed after use siRNA-AMD1-1. Then, analysis potential bioinformatics techniques including GO, KEGG, PPI, immune infiltration molecular docking. has myocardial toxic effects vivo which raised. When knocked down, alleviated. Apoptosis, proliferation inflammation major pathophysiological changes process AMD1-knockdown. This involved IL1A, IL1B, PTGS2, VEGFA, VEGFC HBEFG, as hub genes related Maduramicin. their microenvironment changes: Effector memory CD4 T Natural killer more infiltrated, Mast less infiltrated. exerted cardiotoxic by upregulating gene, may be associated apoptosis, inflammatory response. had function, impact both cells they live.

Язык: Английский

Процитировано

0
Insights into mitochondrial creatine kinase: examining preventive role of creatine supplement in doxorubicin-induced cardiotoxicity DOI
Salaheddin M Sharif,

David S. Hydock

Toxicology Mechanisms and Methods, Год журнала: 2024, Номер unknown, С. 1 - 10

Опубликована: Авг. 21, 2024

Doxorubicin (Dox) is an effective and commonly used anticancer drug; however, it leads to several side effects including cardiotoxicity which contributes poor quality of life for cancer patients. Creatine (Cr) a promising intervention alleviate Dox-induced cardiotoxicity. This study aimed examine the Cr beforeDox on cardiac mitochondrial creatine kinase (MtCK). Male rats were randomly assigned one two 4-week feeding interventions (standard diet or loading diet) control (Con, n = 20). Rats in standard (Cr1, 20) fed 2% 4-weeks. (Cr2, 4% 1-week followed by 3-weeks. After 4-weeks, received either bolus injection 15 mg/kg Dox placebo saline (Sal). Five days post-injections left ventricle (LV) was excised analyzed MtCK expression using Western blot ELISA. A significant drug effect observed LV mass (p < 0.05), post hoc testing revealed Con + Cr2 significantly lower than Sal 0.05). 0.03) through blot. interaction 0.02) Post that had higher Cr1 Sal. Data suggest reduction may contribute cardiotoxicity, supplementation play potential role mitigating preserving CK.

Язык: Английский

Процитировано

2