Combination therapy in combating cancer

Oncotarget, Год журнала: 2017, Номер 8(23), С. 38022 - 38043

Опубликована: Март 30, 2017

// Reza Bayat Mokhtari 1,2,4 , Tina S. Homayouni 1 Narges Baluch 3 Evgeniya Morgatskaya Sushil Kumar Bikul Das 4 and Herman Yeger 1,2 Developmental Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada 2 Department of Paediatric Laboratory Medicine, Children Institute Medical Science, University Pathology Molecular Queen’s University, Kingston, Immunology Infectious Diseases, Forsyth Institute, Cambridge, Massachusetts, USA Correspondence to: Yeger, email: Mokhtari, Keywords : Nrf2-Keap1, HIF-1alpha, carbonic anhydrase 9 (CAIX), histone deacetylase inhibitor (HDACi), (CAI) Received October 19, 2016 Accepted February 27, 2017 Published March 30, Abstract Combination therapy, a treatment modality that combines two or more therapeutic agents, is cornerstone cancer therapy. amalgamation anti-cancer drugs enhances efficacy compared to the mono-therapy approach because it targets key pathways in characteristically synergistic an additive manner. This potentially reduces drug resistance, while simultaneously providing benefits, such as reducing tumour growth metastatic potential, arresting mitotically active cells, stem cell populations, inducing apoptosis. 5-year survival rates most cancers are still quite low, process developing new costly extremely time-consuming. Therefore, strategies target provide efficient effective results at affordable cost being considered. One incorporates repurposing agents initially used different diseases other than cancer. primarily when FDA-approved agent similar found Because one combination therapy already FDA-approved, overall costs research reduced. increases efficiency thereby benefiting “medically underserved”. In addition, repurposed pharmaceutical with therapeutics has shown promising mitigating burden. this systematic review, we discuss important commonly targeted Furthermore, also review primary have gained popularity clinical trials since 2012.

Язык: Английский

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Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy

Cancer Letters, Год журнала: 2017, Номер 402, С. 16 - 31

Опубликована: Май 20, 2017

Язык: Английский

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Plant-Derived Anticancer Compounds as New Perspectives in Drug Discovery and Alternative Therapy

Molecules, Год журнала: 2021, Номер 26(4), С. 1109 - 1109

Опубликована: Фев. 19, 2021

Despite the recent advances in field of chemically synthetized pharmaceutical agents, nature remains main supplier bioactive molecules. The research natural products is a valuable approach for discovery and development novel biologically active compounds possessing unique structures mechanisms action. Although their use belongs to traditional treatment regimes, plant-derived still cover large portion current-day agents. Their medical importance well recognized oncology, especially as an alternative limitations conventional chemotherapy (severe side effects inefficacy due occurrence multi-drug resistance). This review offers comprehensive perspective first blockbuster chemotherapeutic agents origin's (e.g. taxol, vincristine, doxorubicin) mechanism action using 3D representation. In addition portrayed step-by-step evolution from preclinical clinical evaluation most recently studied with potent antitumor activity resveratrol, curcumin, betulinic acid, etc.) terms anticancer possible indications or chemopreventive sensitizers. Finally, this describes several efficient platforms encapsulation targeted delivery cancer treatment.

Язык: Английский

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Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review

Molecules, Год журнала: 2020, Номер 25(6), С. 1397 - 1397

Опубликована: Март 19, 2020

Curcumin exerts a wide range of beneficial physiological and pharmacological activities, including antioxidant, anti-amyloid, anti-inflammatory, anti-microbial, anti-neoplastic, immune-modulating, metabolism regulating, anti-depressant, neuroprotective tissue protective effects. However, its poor solubility absorption in the free form gastrointestinal tract rapid biotransformation to inactive metabolites greatly limit utility as health-promoting agent dietary supplement. Recent advances micro- nano-formulations curcumin with enhanced resulting desirable blood levels active forms now make it possible address potential applications, pain management, protective. Using these highly bioavailable enable broad spectrum appropriate studies be conducted. This review discusses formulations designed enhance bioavailability, curcumin, relationships between particle size relative human pharmacokinetic involving formulated products, widely used but inappropriate practice hydrolyzing plasma samples for quantification current applications promising directions health maintenance applications.

Язык: Английский

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Natural Products as Anticancer Agents: Current Status and Future Perspectives

Molecules, Год журнала: 2022, Номер 27(23), С. 8367 - 8367

Опубликована: Ноя. 30, 2022

Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds synthesized from natural by modifying their structures or using naturally occurring as building blocks in synthesis these for various purposes different fields, such biology, medicine, engineering. Multiple modern costly treatments applied to combat cancer limit its lethality, but results are not significantly refreshing. products, which a significant new therapeutic drugs, currently being investigated potential cytotoxic shown positive trend preclinical research prompted numerous innovative strategies order expedite clinical research. becoming increasingly important drug discovery due high molecular diversity novel biofunctionality. Furthermore, can provide superior efficacy safety unique properties. The objective current review is overview emergence treatment prevention cancer, chemosensitizers, immunotherapeutics, combinatorial therapies with other formulations mechanisms underlying

Язык: Английский

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Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance

Cancers, Год журнала: 2021, Номер 13(17), С. 4363 - 4363

Опубликована: Авг. 28, 2021

The ability of tumor cells to evade apoptosis is established as one the hallmarks cancer. deregulation apoptotic pathways conveys a survival advantage enabling cancer develop multi-drug resistance (MDR), complex phenotype referring concurrent toward agents with different function and/or structure. Proteins implicated in intrinsic pathway apoptosis, including Bcl-2 superfamily and Inhibitors Apoptosis (IAP) family members, well their regulator, suppressor p53, have been development MDR many types. PI3K/AKT pivotal promoting proliferation often overactive tumors. In addition, microenvironment, particularly factors secreted by cancer-associated fibroblasts, can inhibit reduce effectiveness anti-cancer drugs. this review, we describe main alterations that occur apoptosis-and related promote MDR. We also summarize therapeutic approaches against resistant tumors, targeting small molecule inhibitors IAPs or AKT natural origin may be used monotherapy combination conventional therapeutics. Finally, highlight potential exploitation epigenetic modifications reverse phenotype.

Язык: Английский

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Role of Phytochemicals in Cancer Chemoprevention: Insights

Antioxidants, Год журнала: 2021, Номер 10(9), С. 1455 - 1455

Опубликована: Сен. 14, 2021

Cancer is a condition where the body cells multiply in an uncontrollable manner. Chemoprevention of cancer broad term that describes involvement external agents to slow down or suppress growth. Synthetic and natural compounds are found useful chemoprevention. The occurrence global type varies, depending on many factors such as environmental, lifestyle, genetic etc. often preventable developed countries with advanced treatment modalities, whereas it painful death sentence developing low-income due lack modern therapies awareness. One best practice identify control measures study origin risk associated common types. Based these health status patients, stage, severity cancer, decided. Even though there well-established therapies, still stands one major causes public burden globally. Research shows most cancers can be prevented, treated, incidence delayed. Phytochemicals from various medicinal plants were reported reduce different types through their chemopreventive role. This review highlights role bioactive products chemoprevention cancer. There plant based dietary involved process. discusses process carcinogenesis using phytocompounds, special reference five phytocompounds. article also summarizes important mechanisms signaling molecules Since antioxidants inevitable, insight into plant-based antioxidant fight against this dreadful disease at stages progression discussed. will fill research gap search encourage scientists clinical trials anticancer plants.

Язык: Английский

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New insights into therapeutic activity and anticancer properties of curcumin

Journal of Experimental Pharmacology, Год журнала: 2017, Номер Volume 9, С. 31 - 45

Опубликована: Март 1, 2017

Natural compounds obtained from plants are capable of garnering considerable attention the scientific community, primarily due to their ability check and prevent onset progress cancer. These natural used nontoxic nature fewer side effects they cause compared chemotherapeutic drugs. Furthermore, such products perform even better when given as an adjuvant along with traditional drugs, thereby enhancing potential chemotherapeutics simultaneously reducing undesired effects. Curcumin, a naturally occurring polyphenol compound found in plant

Язык: Английский

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Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Cells, Год журнала: 2020, Номер 9(6), С. 1451 - 1451

Опубликована: Июнь 11, 2020

Cancer is a prevalent cause of mortality around the world. Aberrated activation Janus kinase (JAK)/signal transducer and activator transcription (STAT) signaling pathway promotes tumorigenesis. Natural agents, including phytochemicals, exhibit potent anticancer activities via various mechanisms. However, therapeutic potency phytoconstituents as inhibitors JAK/STAT against cancer has only come into focus in recent days. The current review highlights phytochemicals that can suppress order to impede cell growth. Various databases, such PubMed, ScienceDirect, Web Science, SpringerLink, Scopus, Google Scholar, were searched using relevant keywords. Once authors agreement regarding suitability study, full-length form article was obtained, information gathered cited. All complete articles incorporated after literature collection rejection criteria applied perused in-depth material extracted based on importance, relevance, advancement apprehending their relation phytochemicals. Based critical comprehensive analysis presented this review, from diverse plant origins exert preventive effects, at least part, through regulation pathway. Nevertheless, more preclinical clinical research necessary completely comprehend capability modulating achieve efficient control treatment.

Язык: Английский

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The Power of Phytochemicals Combination in Cancer Chemoprevention

Journal of Cancer, Год журнала: 2020, Номер 11(15), С. 4521 - 4533

Опубликована: Янв. 1, 2020

Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses.In contrast, complementary alternative medicine (CAM), employing phytochemicals recently received increased attention owing to their capability modulate a myriad of molecular mechanisms with less toxic effect.Increasing evidence from preclinical clinical studies suggest that can favorably several signaling pathways involved in development progression.Combinations promote cell death, inhibit proliferation invasion, sensitize cancerous cells, boost the immune system, thus making them striking alternatives therapy.We previously investigated effect six (Indol-3-Carbinol, Resveratrol, C-phycocyanin, Isoflavone, Curcumin Quercetin), at bioavailable levels on breast lines were compared primary over period 6 days.This study showed compounds had synergestic inhibiting proliferation, reducing cellular migration inducing both cycle arrest apoptosis.Despite vast number basic science involving phytochemicals, CAM trials still remains nascent.In this review, we summarize findings studies, our work use individually as well combination further discuss potential these pave way integrate health care.

Язык: Английский

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