Cell Biochemistry and Biophysics, Год журнала: 2023, Номер 81(4), С. 621 - 658
Опубликована: Окт. 3, 2023
Язык: Английский
Genes & Diseases, Год журнала: 2023, Номер 11(1), С. 189 - 204
Опубликована: Янв. 14, 2023
Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology, as it represents a major obstacle to effective cancer treatment. Since cells are highly diverse at genetic, epigenetic, and phenotypic levels, intra-tumor can be assumed an important contributing factor nullification chemotherapeutic effects, recurrence tumor. Based on role heterogeneous subpopulations with varying cell-cycle dynamics behavior during progression treatment; herein, we aim establish comprehensive definition for adaptation neoplastic against therapy. We discuss two parallel yet distinct that play pivotal roles reducing effects chemotherapy: "resistant" "tolerant" populations. Furthermore, this review also highlights impact quiescent phase cell cycle survival mechanism cells. Beyond understanding mechanisms underlying quiescence, provides insightful perspective stem (CSCs) their dual intertwined functions based state response Moreover, CSCs, epithelial–mesenchymal transformed cells, circulating (CTCs), disseminated (DTCs), which mostly proved have multiple biological links implicated our viewpoint tumors. Overall, increasing knowledge key identifying new therapeutic solutions, emerging concept may provide us opportunities prevent dreadful recurrence.
Язык: Английский
Процитировано
65
Drug Resistance Updates, Год журнала: 2024, Номер 73, С. 101042 - 101042
Опубликована: Янв. 4, 2024
Drug resistance in cancer remains a major challenge oncology, impeding the effectiveness of various treatment modalities. The nuclear factor-kappa B (NF-κB) signaling pathway has emerged as critical player development drug cells. This comprehensive review explores intricate relationship between NF-κB and cancer. We delve into molecular mechanisms through which activation contributes to against chemotherapeutic agents, targeted therapies, immunotherapies. Additionally, we discuss potential strategies overcome this by targeting signaling, such small molecule inhibitors combination therapies. Understanding multifaceted interactions is crucial for more effective strategies. By dissecting complex network NF-κB, hope shed light on novel therapeutic approaches that can enhance outcomes, ultimately improving prognosis patients. aims provide overview current state knowledge its role resistance, offering insights may guide future research interventions fight
Язык: Английский
Процитировано
37
RSC Advances, Год журнала: 2024, Номер 14(12), С. 8583 - 8601
Опубликована: Янв. 1, 2024
Combining sonochemistry with phytochemistry is a modern trend in the biosynthesis of metallic nanoparticles (NPs), which contributes to sustainability chemical processes and minimizes hazardous effects.
Язык: Английский
Процитировано
12
Cancer Informatics, Год журнала: 2025, Номер 24
Опубликована: Янв. 1, 2025
Objectives: Prostate cancer stem cells (CSCs) play an important role in cell survival, proliferation, metastasis, and recurrence; thus, removing CSCs is for complete removal. However, the mechanisms underlying CSC functions remain largely unknown, making it difficult to develop new anticancer drugs targeting CSCs. Herein, we aimed identify novel factors that regulate stemness predict prognosis. Methods: We reanalyzed 2 single-cell RNA sequencing data of prostate (PCa) tissues using Seurat. used gene set enrichment analysis (GSEA) estimate identified common upregulated genes between these datasets. To investigate whether its expression levels change over differentiation, performed a trajectory monocle 3. In addition, GSEA helped us understand how stemness. Finally, assess their clinical significance, Cancer Genome Atlas database evaluate impact on Results: The thioredoxin ( TXN), redox enzyme, was approximately 1.2 times higher than PCa P < 1 × 10 −10 ), TXN decreased differentiation. suggested intracellular signaling pathways, including MYC, may be involved regulation by TXN. Furthermore, correlated with poor prognosis (P .05) patients high Conclusions: Despite limited sample size our study need further vitro vivo experiments demonstrate functionally regulates CSCs, findings suggest serve as therapeutic target against Moreover, could useful marker predicting patients.
Язык: Английский
Процитировано
1
Seminars in Cancer Biology, Год журнала: 2023, Номер 92, С. 74 - 83
Опубликована: Апрель 11, 2023
Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cells indefinitely perpetuate as well differentiate. stem cell populations within a growing tumor also help evade inhibitory effects chemo- radiation-therapies, in addition playing an important role metastases. NF-κB and STAT-3 are representative transcription factors (TFs) that have long been associated with stemness, thus presenting attractive targets for therapy. The interest non-coding RNAs (ncRNAs) recent years has provided further insight into mechanisms by which TFs influence characteristics. There evidence direct regulation ncRNAs, such as, microRNAs (miRNAs), (lncRNAs) circular (circRNAs), vice versa. Additionally, TF-ncRNAs regulations often indirect, involving ncRNA-target genes or sponging other ncRNA species individual ncRNAs. information rapidly evolving this review provides comprehensive interactions implications on stemness response therapies. Such knowledge will uncover many levels tight control providing novel opportunities therapy process.
Язык: Английский
Процитировано
21
Cells, Год журнала: 2023, Номер 12(16), С. 2083 - 2083
Опубликована: Авг. 17, 2023
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy worldwide, with a poor prognosis limited treatment options. Molecularly targeted therapies for HNSCC are still lacking. However, recent reports provide novel insights about many molecular alterations in that may be useful future therapies. Therefore, it necessary to identify new biomarkers better prediction of disease promising targets personalized therapy. The response therapy attributed small population tumor cells called cancer stem (CSCs). Growing evidence indicates Hedgehog (HH) signaling pathway plays crucial role development maintenance head tissues. HH normally involved embryogenesis, renewal, tissue regeneration. abnormal activation also associated carcinogenesis CSC regulation. Overactivation was observed several tumors, including basal carcinoma, successfully treated inhibitors. clinical studies pathways rare. In this review, we summarize current knowledge advances regarding discuss its possible implications
Язык: Английский
Процитировано
19
Exploration of Targeted Anti-tumor Therapy, Год журнала: 2024, Номер 5(1), С. 20 - 33
Опубликована: Янв. 17, 2024
Pancreatic cancer remains a serious and deadly disease, impacting people globally. There remain prominent gaps in the current understanding of specifically regarding role signal transducer activator transcription (STAT) family proteins pancreatic tumors. STAT proteins, particularly STAT3, play important roles cancer, especially ductal adenocarcinoma (PDAC), which is most prevalent histotype. The STAT3 across continuum molecular processes, such as PDAC tumorigenesis progression, immune escape, drug resistance stemness, modulation tumor microenvironment (TME), are only tip iceberg. In some ways, may hold greater importance than that oncogenic Kirsten rat sarcoma virus (KRAS). This makes highly attractive target for developing targeted therapies treatment cancer. this review, knowledge has been summarized, relating to activation cells, cells TME, state targeting pre-clinical clinical trials PDAC.
Язык: Английский
Процитировано
8
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Апрель 24, 2024
The development of effective therapy for eradicating glioblastoma stem cells remains a major challenge due to their aggressive growth, chemoresistance and radioresistance which are mainly conferred by aldehyde dehydrogenase (ALDH)1A1. latter is the main stemness mediator via enhancing signaling pathways Wnt/β-catenin, phosphatidylinositol 3-kinase/AKT, hypoxia. Furthermore, ALDH1A1 mediates therapeutic resistance inactivating drugs, stimulating expression drug efflux transporters, detoxifying reactive radical species, thereby apoptosis arresting. Recent reports disclosed potent broad-spectrum anticancer activities unique nanocomplexes diethyldithiocarbamate (DE, inhibitor) with ferrous oxide nanoparticles (FeO NPs) inducing lipid peroxidation-dependent non-apoptotic (iron accumulation-triggered ferroptosis), was reported. Accordingly, anti-stemness activity (DE-FeO investigated against human mouse glioma (GSCs) radioresistant GSCs (GSCs-RR). DE-FeO NPs exhibited strongest growth inhibition effect on treated (MGG18 JX39P), (GS PDGF-GSC) (IC 50 ≤ 70 161 μg/mL, respectively). also revealed higher inhibitory impact than standard chemotherapy (temozolomide, TMZ) self-renewal, cancer repopulation, chemoresistance, potentials. Besides, surpassed TMZ regarding relative all studied genes, as well p-AKT/AKT ratio in MGG18, GS (MGG18-RR GS-RR). This influence primarily attributed ferroptosis induction, confirmed significant elevation cellular oxygen species peroxidation depletion glutathione peroxidase 4. recorded optimal Log P value crossing blood brain barrier. vitro novel study declared potency collapsing GSCs-RR improving sensitivity radiotherapy, indicating that may be promising remedy GBM. Glioma animal models will needed in-depth studies its safe effectiveness.
Язык: Английский
Процитировано
8
Science Advances, Год журнала: 2024, Номер 10(25)
Опубликована: Июнь 19, 2024
Pancreatic adenocarcinoma is the fourth leading cause of malignancy-related deaths, with rapid development drug resistance driven by pancreatic cancer stem cells. However, mechanisms sustaining stemness and chemotherapy in ductal (PDAC) remain unclear. Here, we demonstrate that Bicaudal C homolog 1 (BICC1), an RNA binding protein regulating numerous cytoplasmic mRNAs, facilitates chemoresistance PDAC. Mechanistically, BICC1 activated tryptophan catabolism PDAC up-regulating indoleamine 2,3-dioxygenase-1 (IDO1) expression, a tryptophan-catabolizing enzyme. Increased levels metabolites contribute to NAD + synthesis oxidative phosphorylation, cell-like phenotype. Blocking BICC1/IDO1/tryptophan metabolism signaling greatly improves gemcitabine (GEM) efficacy several models high level. These findings indicate critical regulator drives thus potential target for combinatorial therapeutic strategy against chemoresistance.
Язык: Английский
Процитировано
8
Cancer Drug Resistance, Год журнала: 2023, Номер 6(2), С. 273 - 283
Опубликована: Янв. 1, 2023
Colorectal cancer (CRC) is the third most diagnosed and second deadly type of worldwide. In late diagnosis, CRC can resist therapy regimens in which stem cells (CSCs) are intimately related. CSCs a subpopulation tumor responsible for initiation maintenance, metastasis, resistance to conventional treatments. this scenario, colorectal (CCSCs) considered an important key therapeutic failure resistance. its turn, mitochondria organelle involved many mechanisms cancer, including chemoresistance cytotoxic drugs due alterations mitochondrial metabolism, apoptosis, dynamics, mitophagy. Therefore, it crucial understand role CCSCs regarding drug It has been shown that enhanced anti-apoptotic protein expression, mitophagy rate, addiction oxidative phosphorylation major strategies developed by avoid insults. Thus, new mitochondria-targeted approaches must be explored mitigate via ablation CCSCs.
Язык: Английский
Процитировано
16