Oral Cancer Stem Cells: A Comprehensive Review of Key Drivers of Treatment Resistance and Tumor Recurrence

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177222 - 177222

Опубликована: Янв. 1, 2025

Язык: Английский

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Head and neck cancer: pathogenesis and targeted therapy

MedComm, Год журнала: 2024, Номер 5(9)

Опубликована: Авг. 21, 2024

Head and neck cancer (HNC) is a highly aggressive type of tumor characterized by delayed diagnosis, recurrence, metastasis, relapse, drug resistance. The occurrence HNC were associated with smoking, alcohol abuse (or both), human papillomavirus infection, complex genetic epigenetic predisposition. Currently, surgery radiotherapy are the standard treatments for most patients early-stage HNC. For recurrent or metastatic (R/M) HNC, first-line treatment platinum-based chemotherapy combined antiepidermal growth factor receptor cetuximab, when resurgery radiation therapy not an option. However, curing remains challenging, especially in cases metastasis. In this review, we summarize pathogenesis including changes, abnormal signaling pathways, immune regulation mechanisms, along all potential therapeutic strategies such as molecular targeted therapy, immunotherapy, gene modifications, combination therapies. Recent preclinical clinical studies that may offer future research on also discussed. Additionally, new targets methods, antibody-drug conjugates, photodynamic radionuclide mRNA vaccines, have shown promising results trials, offering prospects

Язык: Английский

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Sonidegib Inhibits the Adhesion of Acute Myeloid Leukemia to the Bone Marrow in Hypoxia: An Optical Tweezer Study

Biomedicines, Год журнала: 2025, Номер 13(3), С. 578 - 578

Опубликована: Фев. 25, 2025

Background: Acute myeloid leukemia (AML) is a heterogeneous disease highly resistant to chemotherapeutic agents. Leukemia stem cells (LSCs) can enter dormant state and avoid apoptosis in the protective niche of bone marrow (BM) microenvironment. Moreover, stromal protect by promoting pro-survival signaling pathways drug resistance. Therefore, attenuating interactions between BM may have positive therapeutic effect. Objectives: In this work, we hypothesized that sondages inhibit adhesion inhibiting Hedgehog (Hh) pathway. The pathway key target AML due its role leukemic cell growth survival. Methods: We investigated effects sonidegib on individual OCI-AML3 spheroid derived from HS-5 line. For purpose, precisely determined minimum cell-to-cell time using optical tweezers under normoxic (21% O2) hypoxic (1% conditions. Results: Our results demonstrated significantly increased necessary for establish adhesive bonds with cells, thereby indicating reduction their properties. Additionally, showed particularly effective at oxygen concentrations. Conclusions: obtained study suggest sonidegib, through modulation pathway, holds promise as potential approach within

Язык: Английский

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Phytochemicals and their Nanoformulations for Overcoming Drug Resistance in Head and Neck Squamous Cell Carcinoma

Pharmaceutical Research, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

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Targeting the interplay between human papillomavirus oncoproteins and hedgehog signaling: assessment of chemopreventive potential of carvacrol in cervical cancer

3 Biotech, Год журнала: 2025, Номер 15(4)

Опубликована: Март 5, 2025

Язык: Английский

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Hair follicle stem cells promote epidermal regeneration under expanded condition

Frontiers in Physiology, Год журнала: 2024, Номер 15

Опубликована: Фев. 22, 2024

Skin soft tissue expansion is the process of obtaining excess skin mixed with development, wound healing, and mechanical stretching. Previous studies have reported that significantly induces epidermal proliferation throughout skin. However, mechanisms underlying regeneration during are yet to be clarified. Hair follicle stem cells (HFSCs) been recognized as a promising approach for regeneration. This study examines HFSC-related under expanded condition proposes potential method its cellular molecular regulation.

Язык: Английский

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Multiomics-based molecular subtyping based on the commensal microbiome predicts molecular characteristics and the therapeutic response in breast cancer

Molecular Cancer, Год журнала: 2024, Номер 23(1)

Опубликована: Май 10, 2024

Abstract The gut microbiota has been demonstrated to be correlated with the clinical phenotypes of diseases, including cancers. However, there are few studies on subtyping based microbiota, especially in breast cancer (BC) patients. Here, using machine learning methods, we analysed BC, colorectal (CRC), and gastric (GC) patients identify their shared metabolic pathways importance these development. Based microbiota-related pathways, human gene expression profile patient prognosis, established a novel BC system identified subtype called “challenging BC”. Tumours this have more genetic mutations complex immune environment than those other subtypes. A score index was proposed for in-depth analysis showed significant negative correlation prognosis. Notably, activation TPK1-FOXP3-mediated Hedgehog signalling pathway TPK1-ITGAE-mediated mTOR linked poor prognosis BC” high scores, as validated patient-derived xenograft (PDX) model. Furthermore, our effective predictors response current neoadjuvant therapy regimens, significantly negatively both treatment efficacy number cells. Therefore, findings provide valuable insights into predicting molecular characteristics responses

Язык: Английский

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Current Status of Hedgehog Signaling Inhibitors

Current Topics in Medicinal Chemistry, Год журнала: 2024, Номер 24(3), С. 243 - 258

Опубликована: Янв. 1, 2024

The Hedgehog (Hh) signaling pathway plays a crucial role in diverse biological processes such as cell differentiation, proliferation, senescence, tumorigenesis, malignant transformation, and drug resistance. Aberrant Hh signaling, resulting from mutations excessive activation, can contribute to the development of various diseases during different stages biogenesis development. Moreover, it has been linked unfavorable outcomes several human cancers, including basal carcinoma (BCC), multiple myeloma (MM), melanoma, breast cancer. Hence, presence activation presents obstacles constraints realm cancer treatment. Extant research demonstrated that small molecule inhibitors are regarded most effective therapeutic approaches for targeting contrast traditional chemotherapy radiotherapy. Consequently, this review focuses on present repertoire target components pathway, ligands, Ptch receptors, Smo transmembrane proteins, Gli nuclear transcription factors. This study provides comprehensive analysis molecules' structural functional aspects preclinical clinical management Additionally, elucidates encountered therapy proposes potential approaches.

Язык: Английский

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Elucidating Hedgehog pathway's role in HNSCC progression: insights from a 6-gene signature

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Фев. 26, 2024

Abstract With the emergence of targeted inhibition strategies for Hedgehog signaling in cancer, multiple pathway-related biomarkers have become focus research. SsGSEA algorithm was employed to analyze pathway scores samples TCGA-HNSC dataset and divide them into two groups. Weighted co-expression network analysis performed identify modules strongly associated with pathway. Differentially up-regulated genes tumor comparison normal ones were screened by Limma, which belonging related further filtered LASSO reduction multivariate Cox regression develop a model. ESTIMATE CIBERSORT served characterize microenvironment (TME). TIDE assessed immunotherapy response. activity significantly higher head neck squamous cell carcinoma (HNSCC) tissues than correlated HNSCC survival, glycan, cofactors vitamins, drug metabolism, matrix scores. Six (SLC2A3, EFNB2, OAF, COX4I2, MT2A TXNRD1) captured form 6-gene signature, resulting risk score an independent indicator prognosis. It positively stromal score, angiogenesis inflammatory Patients low-risk group low had sensitivity relative those high-risk group. This study revealed novel findings progression opened up pathology-related signature help factors contributing predict outcomes.

Язык: Английский

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Construction and validation of a TTN mutation associated immune prognostic model for evaluating immune microenvironment and outcomes of gastric cancer: An observational study

Medicine, Год журнала: 2024, Номер 103(29), С. e38979 - e38979

Опубликована: Июль 19, 2024

Gastric cancer (GC) is a prevalent form of worldwide, and TTN (titin) mutations are frequently observed in GC. However, the association between immunotherapy for GC remains unclear, necessitating development novel prognostic models. The value potential mechanisms stomach adenocarcinoma were evaluated by TCGA (The Cancer Genome Atlas)-stomach cohort analysis, an immune model was constructed based on status. We validated it using GSE84433 dataset. performed Gene Set Enrichment Analysis screened differentially expressed genes, used lasso (least absolute shrinkage selection operator) regression analysis to screen survival genes construct multifactorial model. In addition, we relative proportions 22 cells CIBERSORT algorithm immunogenicity analysis. Finally, nomogram integrating other clinical factors. GESA showed enrichment immune-related phenotypes patients with mutations. 16 could identify gastric higher risk poor prognosis. Immuno-microenvironmental increased infiltration naive B cells, plasma monocyte high-risk patients. Nomo plots predicted probability 1-year, 3-year, 5-year OS (overall survival) patients, showing good predictive performance. this study, identified that gene may be biomarker predictor new prognosis characteristics associated This study provide therapeutic strategies cancer.

Язык: Английский

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