Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics
Yang-Nan Ding,
Hui-Yu Wang,
Xiaofeng Chen
и другие.
Circulation Research,
Год журнала:
2025,
Номер
136(5), С. 524 - 550
Опубликована: Фев. 27, 2025
Cardiovascular
diseases
(CVDs)
are
experiencing
a
rapid
surge
and
widely
recognized
as
the
leading
cause
of
mortality
in
current
aging
society.
Given
multifactorial
etiology
CVDs,
understanding
intricate
molecular
cellular
mechanisms
is
imperative.
Over
past
2
decades,
many
scientists
have
focused
on
Sirtuins,
family
nicotinamide
adenine
dinucleotide–dependent
deacylases.
Sirtuins
highly
conserved
across
species,
from
yeasts
to
primates,
play
crucial
role
linking
diseases.
participate
nearly
all
key
physiological
pathological
processes,
ranging
embryogenic
development
stress
response
aging.
Abnormal
expression
activity
exist
aging-related
diseases,
while
their
activation
has
shown
efficacy
mitigating
these
(eg,
CVDs).
In
terms
research,
this
field
maintained
fast,
sustained
growth
recent
years,
fundamental
studies
clinical
trials.
review,
we
present
comprehensive,
up-to-date
discussion
biological
functions
roles
regulating
cardiovascular
biology
CVDs.
Furthermore,
highlight
latest
advancements
utilizing
Sirtuin-activating
compounds
dinucleotide
boosters
potential
pharmacological
targets
for
preventing
treating
The
unresolved
issues
field—from
chemicobiological
regulation
Sirtuin-targeted
CVD
investigations—are
also
discussed.
This
timely
review
could
be
critical
updated
knowledge
Sirtuin
CVDs
facilitating
accessibility
Sirtuin-targeting
interventions.
Язык: Английский
Cellular Senescence and Cardiovascular Aging
Опубликована: Янв. 1, 2025
Body Composition and Senescence: Impact of Polyphenols on Aging-Associated Events
Nutrients,
Год журнала:
2024,
Номер
16(21), С. 3621 - 3621
Опубликована: Окт. 25, 2024
Aging
is
a
dynamic
and
progressive
process
characterized
by
the
gradual
accumulation
of
cellular
damage.
The
continuous
functional
decline
in
intrinsic
capacity
living
organisms
to
precisely
regulate
homeostasis
leads
an
increased
susceptibility
vulnerability
diseases.
Among
factors
contributing
these
changes,
body
composition-comprised
fat
mass
lean
deposits-plays
crucial
role
trajectory
disability.
Particularly,
visceral
intermuscular
deposits
increase
with
aging
are
associated
adverse
health
outcomes,
having
been
linked
pathogenesis
sarcopenia.
Adipose
tissue
involved
secretion
bioactive
that
can
ultimately
mediate
inter-organ
pathology,
including
skeletal
muscle
through
induction
pro-inflammatory
profile
such
as
SASP,
senescence,
immunosenescence,
among
other
events.
Extensive
research
has
shown
natural
compounds
have
ability
modulate
mechanisms
addition
exhibiting
anti-inflammatory,
antioxidant,
immunomodulatory
potential,
making
them
interesting
strategies
for
promoting
healthy
aging.
In
this
review,
we
will
discuss
how
senescence
presence
phenotype
negatively
impact
composition
lead
development
age-related
diseases,
well
use
polyphenols
be
measure
restoring
balance,
maintaining
quality
composition,
health.
Язык: Английский
Proteomic Profiling of Endothelial Cell Secretomes After Exposure to Calciprotein Particles Reveals Downregulation of Basement Membrane Assembly and Increased Release of Soluble CD59
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11382 - 11382
Опубликована: Окт. 23, 2024
Calciprotein
particles
(CPPs)
are
essential
circulating
scavengers
of
excessive
Ca
Язык: Английский