Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics

Circulation Research, Journal Year: 2025, Volume and Issue: 136(5), P. 524 - 550

Published: Feb. 27, 2025

Cardiovascular diseases (CVDs) are experiencing a rapid surge and widely recognized as the leading cause of mortality in current aging society. Given multifactorial etiology CVDs, understanding intricate molecular cellular mechanisms is imperative. Over past 2 decades, many scientists have focused on Sirtuins, family nicotinamide adenine dinucleotide–dependent deacylases. Sirtuins highly conserved across species, from yeasts to primates, play crucial role linking diseases. participate nearly all key physiological pathological processes, ranging embryogenic development stress response aging. Abnormal expression activity exist aging-related diseases, while their activation has shown efficacy mitigating these (eg, CVDs). In terms research, this field maintained fast, sustained growth recent years, fundamental studies clinical trials. review, we present comprehensive, up-to-date discussion biological functions roles regulating cardiovascular biology CVDs. Furthermore, highlight latest advancements utilizing Sirtuin-activating compounds dinucleotide boosters potential pharmacological targets for preventing treating The unresolved issues field—from chemicobiological regulation Sirtuin-targeted CVD investigations—are also discussed. This timely review could be critical updated knowledge Sirtuin CVDs facilitating accessibility Sirtuin-targeting interventions.

Language: Английский

---

Cellular Senescence and Cardiovascular Aging

Published: Jan. 1, 2025

---

Body Composition and Senescence: Impact of Polyphenols on Aging-Associated Events

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3621 - 3621

Published: Oct. 25, 2024

Aging is a dynamic and progressive process characterized by the gradual accumulation of cellular damage. The continuous functional decline in intrinsic capacity living organisms to precisely regulate homeostasis leads an increased susceptibility vulnerability diseases. Among factors contributing these changes, body composition-comprised fat mass lean deposits-plays crucial role trajectory disability. Particularly, visceral intermuscular deposits increase with aging are associated adverse health outcomes, having been linked pathogenesis sarcopenia. Adipose tissue involved secretion bioactive that can ultimately mediate inter-organ pathology, including skeletal muscle through induction pro-inflammatory profile such as SASP, senescence, immunosenescence, among other events. Extensive research has shown natural compounds have ability modulate mechanisms addition exhibiting anti-inflammatory, antioxidant, immunomodulatory potential, making them interesting strategies for promoting healthy aging. In this review, we will discuss how senescence presence phenotype negatively impact composition lead development age-related diseases, well use polyphenols be measure restoring balance, maintaining quality composition, health.

Language: Английский

---

Proteomic Profiling of Endothelial Cell Secretomes After Exposure to Calciprotein Particles Reveals Downregulation of Basement Membrane Assembly and Increased Release of Soluble CD59

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11382 - 11382

Published: Oct. 23, 2024

Calciprotein particles (CPPs) are essential circulating scavengers of excessive Ca

Language: Английский

---