Curcumins from <em>Curcuma longa </em>Potential Inhibit PTP1B and α-Glucosidase: Experimental and Computational Study DOI Open Access

Thi-Tu Dinh,

Anh-Tuan Nguyen, Phạm Minh Quân

и другие.

Опубликована: Апрель 25, 2023

Curcuma longa is only a rich source of curcumin (1) and its major analogues demethoxycurcumin (2) bisdemethoxycurcumin (3) among the species. The content ratio these three curcumins in turmeric depended on varieties growing environment. Recently, has been reported as potential inhibitor hepatic enzymatic protein tyrosine phosphatase 1B (PTP1B) related disorders such hypertriglyceridemia, hyperlipidemia liver steatosis. Thus, we further purified (1–3) from C. investigated their inhibitory effects against PTP1B α-glucosidase enzymes. As result, exhibited inhibition with IC50 values 37.8 ± 1.4, 45.3 0.7, 72.6 1.1 μM, respectively, similar manner (IC50 78.2 0.2, 82.4 0.6, 90.6 1.0 respectively). These results reveal key role methoxylation variation activity for curcumins. In addition, density functional theory (DFT) was used accompanying molecular docking (MD) to analyze ligand stability interaction glucoside hydrolase proteins. Assay-based MD data obtained are highly correlation suggesting that deterioration enzyme caused by distortion structural conformation may be arrangement amino acids structure. This first time have examined vitro silico well.

Язык: Английский

Molecules and targets of antidiabetic interest DOI Creative Commons
Kavishankar Gawli,

Kavya Sritha Bojja

Phytomedicine Plus, Год журнала: 2023, Номер 4(1), С. 100506 - 100506

Опубликована: Ноя. 8, 2023

The review is a comprehensive overview of targets antidiabetic interest and molecules that are reported to possess modulatory effects on glucose homeostasis. Drugs available in the market treat diabetes restore blood levels normal but associated with undesirable effects. This has compelled investigators search for more benign candidate molecule could counter high glucose, minimize, or diminish further complications improve lifestyle. In light this, literature survey was performed using scientific databases viz., PubMed, Scopus, Google scholar EMBASE. Twenty 233 molecules, their source, structure, chemical formula, IC50 values mechanism action described. focused growing discovering novel such as antagonists glucagon glucocorticoids receptor, inhibitors aldose reductase, fructose-1,6-bisphosphatase, glycogen phosphorylase have led effective clinical development. enzyme inhibitors, antagonists, agonists, blockers receptors be plant-derived metabolites therefore, can target cellular molecular mechanisms leading Overall, information provided here serve guide drug-based companies explore listed developing potential drug candidates fewer no side

Язык: Английский

Процитировано

3
Curcumins from <em>Curcuma longa </em>Potential Inhibit PTP1B and α-Glucosidase: Experimental and Computational Study DOI Open Access

Thi-Tu Dinh,

Anh-Tuan Nguyen, Phạm Minh Quân

и другие.

Опубликована: Апрель 25, 2023

Curcuma longa is only a rich source of curcumin (1) and its major analogues demethoxycurcumin (2) bisdemethoxycurcumin (3) among the species. The content ratio these three curcumins in turmeric depended on varieties growing environment. Recently, has been reported as potential inhibitor hepatic enzymatic protein tyrosine phosphatase 1B (PTP1B) related disorders such hypertriglyceridemia, hyperlipidemia liver steatosis. Thus, we further purified (1–3) from C. investigated their inhibitory effects against PTP1B α-glucosidase enzymes. As result, exhibited inhibition with IC50 values 37.8 ± 1.4, 45.3 0.7, 72.6 1.1 μM, respectively, similar manner (IC50 78.2 0.2, 82.4 0.6, 90.6 1.0 respectively). These results reveal key role methoxylation variation activity for curcumins. In addition, density functional theory (DFT) was used accompanying molecular docking (MD) to analyze ligand stability interaction glucoside hydrolase proteins. Assay-based MD data obtained are highly correlation suggesting that deterioration enzyme caused by distortion structural conformation may be arrangement amino acids structure. This first time have examined vitro silico well.

Язык: Английский

Процитировано

2