Warm alkaline hydrogen peroxide solution as an oxygen-releasing antihypoxic drug: potential benefits and applications
Medical Gas Research,
Год журнала:
2024,
Номер
15(1), С. 134 - 135
Опубликована: Окт. 2, 2024
Язык: Английский
New generation antihypoxants: alkaline hydrogen peroxide solutions as medical oxygen gas generators
Psychopharmacology & biological narcology,
Год журнала:
2025,
Номер
16(1), С. 35 - 42
Опубликована: Апрель 18, 2025
The
cause
of
biological
death
in
warm-blooded
animals
and
humans
is
hypoxic
brain
cell
damage.
Consequently,
oxygen
gas
the
leading
antihypoxant
emergency
medical
care
for
all
critical
conditions.
most
common
method
administration
mechanical
ventilation.
However,
cases
asphyxia
caused
by
airway
obstruction
with
thick
sputum,
mucus,
pus,
and/or
blood,
inhaled
does
not
reach
alveoli
absorbed
into
bloodstream.
In
such
situations,
traditional
ventilation
becomes
ineffective
fails
to
prevent
due
At
beginning
21st
century,
as
an
alternative
gaseous
oxygen,
ventilation,
extracorporeal
membrane
oxygenation,
development
intrapulmonary
oxygen-producing
antihypoxants
through
physicochemical
repurposing
hydrogen
peroxide
was
initiated
Russia.
Professor
P.D.
Shabanov
served
mind
behind
coordinator
new-generation
antihypoxants.
A
new
group
—
warm
alkaline
solutions
discovered.
effective
antihypoxants,
when
applied
locally
via
route,
generate
significant
volumes
catalase-mediated
decomposition
water
molecular
oxygen.
local
intrapulmonary,
endotracheal,
endobronchial
pharmacodynamics
pharmacokinetics
are
inseparable
from
interactions
catalase
present
serous
fluids,
purulent
masses,
blood
that
obstruct
airways
during
severe
acute
respiratory
obstruction.
generation
has
demonstrated
high
therapeutic
potential
powerful
generators
administered
intrapulmonarily,
endobronchially,
or
endotracheally
suffocation
blockage
colloidal
liquids
containing
catalase.
It
hypothesized
could
be
considered
agents
saturation
lungs
oxygenation
feasible.
Язык: Английский
Intrapulmonary and intrabronchial oxygen-producing antihypoxants eliminate asphyxia and hypoxemia
Medical Gas Research,
Год журнала:
2025,
Номер
15(4), С. 550 - 551
Опубликована: Апрель 29, 2025
Язык: Английский
Suffocation in asthma and COVID-19: Supplementation of inhaled corticosteroids with alkaline hydrogen peroxide as an alternative to ECMO
Опубликована: Июль 11, 2023
Suffocation
syndrome
is
the
leading
cause
of
hypoxia
and
mortality
in
most
common
lung
diseases,
asthma
COVID-19.
Inhaled
corticosteroids
(ICSs)
have
been
shown
to
be
main-stay
critical
care
these
diseases.
Meanwhile,
from
strangulated
highest
low-income
countries
because
ICSs
are
not
currently
available
many
patients.
Warm
alkaline
hydrogen
peroxide
solutions
(WAHPSs)
reportedly
invented
recent
years
urgently
turn
thick
sputum,
mucus,
pus,
serous
fluid,
blood
clots
other
biological
masses
con-taining
enzyme
catalase
into
a
fluffy
oxygenated
foam.
It
has
that
mechanism
action
WAHPSs
consists
saponification
lipid
protein-lipid
complexes
bi-ological
their
transformation
oxygen
foam,
decomposed
water
gas
under
At
excess
absorbed
through
lungs
increases
saturation.
Based
on
described
high
availability
ingre-dients,
it
suggested
choking
COVID-19
can
reduced
by
combining
with
inhaled
WAHPSs,
especially
poor
countries.
The
essence
inventions
underlying
formation
given.
Язык: Английский
Hypoxic irreversible brain cells damage, associated risk factors and antihypoxants
Reviews on Clinical Pharmacology and Drug Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 19, 2024
It
is
reported
that
in
the
final
stage
of
many
diseases
immediate
cause
biological
death
humans
and
warm-blooded
animals
hypoxic
irreversible
damage
to
brain
cells.
This
explains
fact
prevent
all
critical
conditions
without
exception,
inhalation
with
breathing
gases
containing
oxygen
has
long
been
successfully
used.
also
why
oxygenation
blood
considered
one
main
for
preserving
human
life
situations
forms
basis
emergency
medical
care
intensive
unit.
However,
gas
increasing
saturation
should
be
carried
out
as
early
possible,
more
precisely
-
before
onset
The
after
cells
die
even
presence
oxygen.
In
this
connection,
mechanisms
adaptation
organism
deficiency
play
a
great
role
longer
preservation
viability
hypoxemia.
order
increase
resistance
hypoxemia,
antihypoxants
are
traditionally
But
they
can
preserve
not
always,
but
only
if
introduced
into
body
case
unused
reserves
hypoxemia
body.
Risk
factors
indicated,
among
which
excessively
duration
hyperthermia
emphasized.
shown
most
important
circumstance
development
so
much
degree
hypoxia
tissue
its
duration,
exceeds
period
hypoxia.
assessed
using
Stange
test.
fever
local
cerebral
decrease,
hibernation
hypothermia
increase,
regard,
recommendations
eliminate
inflammatory
processes
head,
reduce
temperature
highly
appropriate
improve
pointed
methods
therapeutic
hypothermia,
targeted
management
advanced.
addition,
it
recent
years
new
group
promising
alkaline
solutions
hydrogen
peroxide
created.
able
decompose
very
quickly
water
under
action
catalase,
found
tissues.
peculiarities
we
have
study
future.
Язык: Английский
Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds
Reviews on Clinical Pharmacology and Drug Therapy,
Год журнала:
2023,
Номер
21(4), С. 287 - 297
Опубликована: Ноя. 29, 2023
The
traditional
treatment
of
chronic
wounds
involves
daily
cleansing
the
wound
surface
from
purulent
necrotic
masses
using
mechanical
and
medicinal
methods,
accompanied
by
regular
replacement
dressing.
In
this
case,
lasts
10–15
mins
time
old
dressing
with
new
one.
According
to
established
practice,
sanitation
infected
during
irrigation
solutions,
antiseptics,
and/or
antibiotics.
severe
cases,
above
therapy
is
supplemented
live
larvae
necrophage
fly,
which
are
injected
into
left
in
them
under
until
completely
cleansed
pus.
Nevertheless,
generally
accepted
course
remains
ineffective.
use
pyolytics
their
supplementation
dressings
form
warm
wet
compresses,
create
a
local
greenhouse
effect
wounds,
was
reported
accelerate
healing
wounds.
Pyolytics
group
antiseptics
developed
Russia.
They
alkaline
solutions
hydrogen
peroxide;
when
they
interact
masses,
these
dissolve
very
quickly
foam
them.
Because
interaction
pyolytics,
thick
immediately
turn
fluffy
oxygenated
foam.
have
been
because
physicochemical
repurposing
aqueous
sodium
carbonate
peroxide.
To
recommendation
irrigate
3%
peroxide
2–10%
bicarbonate
heated
37–45°C,
activity
at
pH
8.4–8.5
enriched
dissolved
carbon
dioxide
or
oxygen
(due
excess
pressure
0.2
atm).
This
study
presented
importance
treating
politics
outcomes
along
moist
demonstrating
wound-healing
effect.
Consequently,
physical
chemical
reprofiling
may
make
effective
combination
such
as
on
accelerates
Язык: Английский
The preliminary introduction of hydrogen peroxide into the stomach of aquarium fish increases their survival rate in conditions of acute hypoxia
Reviews on Clinical Pharmacology and Drug Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 26, 2024
BACKGROUND:
A
solution
of
3%
hydrogen
peroxide
is
an
over-the-counter
oxygen-releasing
antiseptic,
which
forms
oxygen
foam
when
interacting
locally
with
the
wound
surface.
Therefore,
this
drug
widely
used
for
mechanical
cleansing
surface
chronic
wounds
from
purulent
masses.
The
release
during
catalase
cleavage
indicates
possibility
achieving
anti-ischemic
and
anti-hypoxic
action.
AIM:
study
effect
intragastric
on
resistance
aquarium
fish
to
acute
hypoxia.
MATERIALS
AND
METHODS:
Experiments
were
conducted
80
adult
guppy,
blue
neon,
tri-linear
parsings,
swordtail
zebrafish
(Danio
rerio)
breeds.
To
create
hypoxia,
each
was
placed
in
a
transparent
plastic
container
containing
5,
10
or
20
ml
fresh
water
at
temperature
+25
-
+26
°C
together
fish,
after
hermetically
sealed.
Then,
motor
activity
fish's
body,
respiratory
movements
gill
arches,
opening
oral
cavity,
fluctuations
fins
dynamics
their
coloration
monitored
until
complete
final
immobilization
death.
Immediately
before
experiment,
0.05
0.1
control
series
0.05%
experimental
injected
into
stomach
fish.
liquid
using
gastric
mini-probe
connected
insulin
syringe.
RESULTS:
It
shown
that
retain
viability
small
volume
inside
sealed
limited
period
time,
since
continuously
consume
dissolved
water,
thereby
deepening
At
same
sealing
container,
very
quickly
assume
stationary
state,
they
remain
certain
time
However,
just
death,
immobility
disturbed.
suddenly
appear
convulsive
body
movements,
active
pectoral
fins,
mouths
change
color,
defecate
water.
results
showed
preliminary
injection
prolongs
hypoxia
by
average
20%.
In
all
likelihood,
immobile
state
part
complex
adaptive
adjustment
cessation
supply
reflects
availability
reserves
adaptation
fact
absence
muscle
contractions
stops
muscles
oxygen,
use
generate
energy.
assumed
stomach,
absorbed
blood,
where,
under
action
enzyme
catalase,
it
split
gaseous
replaces
gills
surrounding
CONCLUSIONS:
Under
model
conditions,
pre-administration
increases
survival
conditions
can
be
considered
as
potential
antihypoxant
prolonging
life
various
types
suffocation,
including
stage
COVID-19.
Язык: Английский