The preliminary introduction of hydrogen peroxide into the stomach of aquarium fish increases their survival rate in conditions of acute hypoxia DOI

Evgeny Fisher,

Aleksandr Urakov, Петр Д. Шабанов

и другие.

Reviews on Clinical Pharmacology and Drug Therapy, Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

BACKGROUND: A solution of 3% hydrogen peroxide is an over-the-counter oxygen-releasing antiseptic, which forms oxygen foam when interacting locally with the wound surface. Therefore, this drug widely used for mechanical cleansing surface chronic wounds from purulent masses. The release during catalase cleavage indicates possibility achieving anti-ischemic and anti-hypoxic action. AIM: study effect intragastric on resistance aquarium fish to acute hypoxia. MATERIALS AND METHODS: Experiments were conducted 80 adult guppy, blue neon, tri-linear parsings, swordtail zebrafish (Danio rerio) breeds. To create hypoxia, each was placed in a transparent plastic container containing 5, 10 or 20 ml fresh water at temperature +25 - +26 °C together fish, after hermetically sealed. Then, motor activity fish's body, respiratory movements gill arches, opening oral cavity, fluctuations fins dynamics their coloration monitored until complete final immobilization death. Immediately before experiment, 0.05 0.1 control series 0.05% experimental injected into stomach fish. liquid using gastric mini-probe connected insulin syringe. RESULTS: It shown that retain viability small volume inside sealed limited period time, since continuously consume dissolved water, thereby deepening At same sealing container, very quickly assume stationary state, they remain certain time However, just death, immobility disturbed. suddenly appear convulsive body movements, active pectoral fins, mouths change color, defecate water. results showed preliminary injection prolongs hypoxia by average 20%. In all likelihood, immobile state part complex adaptive adjustment cessation supply reflects availability reserves adaptation fact absence muscle contractions stops muscles oxygen, use generate energy. assumed stomach, absorbed blood, where, under action enzyme catalase, it split gaseous replaces gills surrounding CONCLUSIONS: Under model conditions, pre-administration increases survival conditions can be considered as potential antihypoxant prolonging life various types suffocation, including stage COVID-19.

Язык: Английский

Warm alkaline hydrogen peroxide solution as an oxygen-releasing antihypoxic drug: potential benefits and applications DOI
А. N. Osipov, Natalya Urakova,

Aleksandr L. Urakov

и другие.

Medical Gas Research, Год журнала: 2024, Номер 15(1), С. 134 - 135

Опубликована: Окт. 2, 2024

Язык: Английский

Процитировано

3

New generation antihypoxants: alkaline hydrogen peroxide solutions as medical oxygen gas generators DOI
Natalya Urakova, Aleksandr Urakov

Psychopharmacology & biological narcology, Год журнала: 2025, Номер 16(1), С. 35 - 42

Опубликована: Апрель 18, 2025

The cause of biological death in warm-blooded animals and humans is hypoxic brain cell damage. Consequently, oxygen gas the leading antihypoxant emergency medical care for all critical conditions. most common method administration mechanical ventilation. However, cases asphyxia caused by airway obstruction with thick sputum, mucus, pus, and/or blood, inhaled does not reach alveoli absorbed into bloodstream. In such situations, traditional ventilation becomes ineffective fails to prevent due At beginning 21st century, as an alternative gaseous oxygen, ventilation, extracorporeal membrane oxygenation, development intrapulmonary oxygen-producing antihypoxants through physicochemical repurposing hydrogen peroxide was initiated Russia. Professor P.D. Shabanov served mind behind coordinator new-generation antihypoxants. A new group — warm alkaline solutions discovered. effective antihypoxants, when applied locally via route, generate significant volumes catalase-mediated decomposition water molecular oxygen. local intrapulmonary, endotracheal, endobronchial pharmacodynamics pharmacokinetics are inseparable from interactions catalase present serous fluids, purulent masses, blood that obstruct airways during severe acute respiratory obstruction. generation has demonstrated high therapeutic potential powerful generators administered intrapulmonarily, endobronchially, or endotracheally suffocation blockage colloidal liquids containing catalase. It hypothesized could be considered agents saturation lungs oxygenation feasible.

Язык: Английский

Процитировано

0

Intrapulmonary and intrabronchial oxygen-producing antihypoxants eliminate asphyxia and hypoxemia DOI
Natalya Urakova, Aleksandr Urakov, Петр Д. Шабанов

и другие.

Medical Gas Research, Год журнала: 2025, Номер 15(4), С. 550 - 551

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

0

Suffocation in asthma and COVID-19: Supplementation of inhaled corticosteroids with alkaline hydrogen peroxide as an alternative to ECMO DOI Open Access
Aleksandr Urakov, Natalya Urakova, Петр Д. Шабанов

и другие.

Опубликована: Июль 11, 2023

Suffocation syndrome is the leading cause of hypoxia and mortality in most common lung diseases, asthma COVID-19. Inhaled corticosteroids (ICSs) have been shown to be main-stay critical care these diseases. Meanwhile, from strangulated highest low-income countries because ICSs are not currently available many patients. Warm alkaline hydrogen peroxide solutions (WAHPSs) reportedly invented recent years urgently turn thick sputum, mucus, pus, serous fluid, blood clots other biological masses con-taining enzyme catalase into a fluffy oxygenated foam. It has that mechanism action WAHPSs consists saponification lipid protein-lipid complexes bi-ological their transformation oxygen foam, decomposed water gas under At excess absorbed through lungs increases saturation. Based on described high availability ingre-dients, it suggested choking COVID-19 can reduced by combining with inhaled WAHPSs, especially poor countries. The essence inventions underlying formation given.

Язык: Английский

Процитировано

7

Hypoxic irreversible brain cells damage, associated risk factors and antihypoxants DOI
Aleksandr Urakov, Natalya Urakova, Петр Д. Шабанов

и другие.

Reviews on Clinical Pharmacology and Drug Therapy, Год журнала: 2024, Номер unknown

Опубликована: Авг. 19, 2024

It is reported that in the final stage of many diseases immediate cause biological death humans and warm-blooded animals hypoxic irreversible damage to brain cells. This explains fact prevent all critical conditions without exception, inhalation with breathing gases containing oxygen has long been successfully used. also why oxygenation blood considered one main for preserving human life situations forms basis emergency medical care intensive unit. However, gas increasing saturation should be carried out as early possible, more precisely - before onset The after cells die even presence oxygen. In this connection, mechanisms adaptation organism deficiency play a great role longer preservation viability hypoxemia. order increase resistance hypoxemia, antihypoxants are traditionally But they can preserve not always, but only if introduced into body case unused reserves hypoxemia body. Risk factors indicated, among which excessively duration hyperthermia emphasized. shown most important circumstance development so much degree hypoxia tissue its duration, exceeds period hypoxia. assessed using Stange test. fever local cerebral decrease, hibernation hypothermia increase, regard, recommendations eliminate inflammatory processes head, reduce temperature highly appropriate improve pointed methods therapeutic hypothermia, targeted management advanced. addition, it recent years new group promising alkaline solutions hydrogen peroxide created. able decompose very quickly water under action catalase, found tissues. peculiarities we have study future.

Язык: Английский

Процитировано

1

Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds DOI Open Access
Aleksandr Urakov, Natalya Urakova, А. П. Решетников

и другие.

Reviews on Clinical Pharmacology and Drug Therapy, Год журнала: 2023, Номер 21(4), С. 287 - 297

Опубликована: Ноя. 29, 2023

The traditional treatment of chronic wounds involves daily cleansing the wound surface from purulent necrotic masses using mechanical and medicinal methods, accompanied by regular replacement dressing. In this case, lasts 10–15 mins time old dressing with new one. According to established practice, sanitation infected during irrigation solutions, antiseptics, and/or antibiotics. severe cases, above therapy is supplemented live larvae necrophage fly, which are injected into left in them under until completely cleansed pus. Nevertheless, generally accepted course remains ineffective. use pyolytics their supplementation dressings form warm wet compresses, create a local greenhouse effect wounds, was reported accelerate healing wounds. Pyolytics group antiseptics developed Russia. They alkaline solutions hydrogen peroxide; when they interact masses, these dissolve very quickly foam them. Because interaction pyolytics, thick immediately turn fluffy oxygenated foam. have been because physicochemical repurposing aqueous sodium carbonate peroxide. To recommendation irrigate 3% peroxide 2–10% bicarbonate heated 37–45°C, activity at pH 8.4–8.5 enriched dissolved carbon dioxide or oxygen (due excess pressure 0.2 atm). This study presented importance treating politics outcomes along moist demonstrating wound-healing effect. Consequently, physical chemical reprofiling may make effective combination such as on accelerates

Язык: Английский

Процитировано

1

The preliminary introduction of hydrogen peroxide into the stomach of aquarium fish increases their survival rate in conditions of acute hypoxia DOI

Evgeny Fisher,

Aleksandr Urakov, Петр Д. Шабанов

и другие.

Reviews on Clinical Pharmacology and Drug Therapy, Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

BACKGROUND: A solution of 3% hydrogen peroxide is an over-the-counter oxygen-releasing antiseptic, which forms oxygen foam when interacting locally with the wound surface. Therefore, this drug widely used for mechanical cleansing surface chronic wounds from purulent masses. The release during catalase cleavage indicates possibility achieving anti-ischemic and anti-hypoxic action. AIM: study effect intragastric on resistance aquarium fish to acute hypoxia. MATERIALS AND METHODS: Experiments were conducted 80 adult guppy, blue neon, tri-linear parsings, swordtail zebrafish (Danio rerio) breeds. To create hypoxia, each was placed in a transparent plastic container containing 5, 10 or 20 ml fresh water at temperature +25 - +26 °C together fish, after hermetically sealed. Then, motor activity fish's body, respiratory movements gill arches, opening oral cavity, fluctuations fins dynamics their coloration monitored until complete final immobilization death. Immediately before experiment, 0.05 0.1 control series 0.05% experimental injected into stomach fish. liquid using gastric mini-probe connected insulin syringe. RESULTS: It shown that retain viability small volume inside sealed limited period time, since continuously consume dissolved water, thereby deepening At same sealing container, very quickly assume stationary state, they remain certain time However, just death, immobility disturbed. suddenly appear convulsive body movements, active pectoral fins, mouths change color, defecate water. results showed preliminary injection prolongs hypoxia by average 20%. In all likelihood, immobile state part complex adaptive adjustment cessation supply reflects availability reserves adaptation fact absence muscle contractions stops muscles oxygen, use generate energy. assumed stomach, absorbed blood, where, under action enzyme catalase, it split gaseous replaces gills surrounding CONCLUSIONS: Under model conditions, pre-administration increases survival conditions can be considered as potential antihypoxant prolonging life various types suffocation, including stage COVID-19.

Язык: Английский

Процитировано

0