Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 258 - 258

Published: Jan. 15, 2024

Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is congenital blood disorder characterized by considerable phenotypic diversity. It comprises group of disorders, with sickle anemia (SCA) being most prevalent serious genotype. Although there have been some systematic reviews global data, worldwide statistics regarding SCD prevalence, morbidity, mortality remain scarce. In developed countries lower number patients, cutting-edge technologies led to development new treatments. However, developing settings where (SCD) more prevalent, medical management, rather than cure, still relies on use hydroxyurea, transfusions, analgesics. This that affects red cells, consequently affecting organs diverse manners. We discuss its etiology advent technologies, but aim this study understand various types nutrition-related studies involving individuals suffering from SCD, particularly Africa. The interplay environment, food, gut microbiota, along their respective genomes collectively known as microbiome, host metabolism responsible for mediating metabolic phenotypes modulating microbiota. addition, it serves purpose providing essential nutrients. Moreover, engages direct interactions homeostasis immune system, well indirect via metabolites. Nutrition interventions nutritional care are mechanisms addressing increased nutrient expenditures important aspects supportive management patients SCD. Underprivileged areas Sub-Saharan Africa should be accompanied efforts define promote Their importance key maintaining well-being quality life, especially because products limited, while native medicinal plant resources acknowledged.

Language: Английский

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Crosstalk Between Sickle Cell Disease and Ferroptosis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3675 - 3675

Published: April 13, 2025

Sickle cell disease (SCD) is an inherited hemoglobin disorder that widespread across the globe. It characterized by a very complex pathogenesis, but at basis of mutation HBB gene, which determines production mutated hemoglobin: sickle (HbS). The polymerization HbS, occurs when protein in deoxygenated state, and greater fragility red blood cells (sRBCs) determine release iron, free heme, HbS blood, favoring oxidative stress reactive oxygen species (ROS). These features are common to new model death known as ferroptosis, increase iron ROS concentrations inhibition glutathione peroxidase 4 (GPx4) System Xc−. In this context, review aims discuss potential molecular biochemical pathways ferroptosis involved SCD, aiming highlight possible tags treating inhibiting ferroptosis.

Language: Английский

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A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle cell Anaemia

Published: July 17, 2023

Abstract Sickle cell anaemia (SCD) is a life-threatening haematological disorder which predominant in sub-Saharan Africa and triggered by genetic mutation of the β-chain haemoglobin gene resulting substitution glutamic acid with valine. This leads to production an abnormal molecule called S (HbS). When deoxygenated, (HbS) polymerizes results sickle-shaped red blood rigid has significantly shortened life span. Various reports have shown strong link between oxidative stress, inflammation, immune response, pathogenesis sickle disease. The consequence these processes lead development vasculopathy (disease vessels) several other complications. role system, particularly innate SCD become increasingly clear recent years research, However, little known about roles adaptive system this review examines interaction transfusion, their effects on

Language: Английский

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Evaluating the Diagnostic and Prognostic Roles of Fibrinogen Degradation Products and C-reactive Protein in Management of Sickle Cell Disease

Published: Dec. 13, 2024

Introduction: Abnormal hemoglobin is a hallmark of sickle cell disease (SCD), genetic blood abnormality that can cause number clinical consequences, such as vaso-occlusive crises and an elevated risk infection.One potential biomarker for evaluating activity consequences in SCD patients C-reactive protein (CRP), acute-phase reactant frequently increased inflammatory conditions.Aim/Objectives: The purpose this study to assess the diagnostic prognostic value FDP CRP levels at University College Hospital Ibadan, Nigeria.

Language: Английский

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Individuals afflicted with concurrent anemia, tuberculosis, and Candida albicans infection manifest: A pronounced state of immunosuppression

Open Journal of Clinical and Medical Case Reports, Journal Year: 2023, Volume and Issue: 9(36)

Published: Oct. 20, 2023

This study delved into the immune functionality of individuals grappling with anemia, tuberculosis, and Candida albicans infection. The findings conclusively revealed that this cohort manifested a pronounced state immunosuppression, thereby emphasizing intricate interplay these concurrent maladies on landscape. Subsequent investigations should aim to unravel underlying mechanisms orchestrating immunosuppressive milieu contemplate potential interventions aimed at alleviating its impact response dynamics.

Language: Английский

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