Investigation of Silicon Oxide Nanoparticle-Enhanced Self-Healing Hydrogel for Cartilage Repair and Regeneration in Rabbit Earlobe Models DOI
Seyedeh‐Sara Hashemi, Reza Alizadeh, Alireza Rafati

и другие.

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 24

Опубликована: Фев. 28, 2025

This study developed an alginate, gelatin, and chondroitin sulfate hydrogel incorporating silicon oxide nanoparticles to assess morphology, cell proliferation, viability. The effectiveness of these hydrogels for cartilage repair was evaluated in vivo using male albino rabbits, divided into three groups: a control group without hydrogels, observer with lacking nanoparticles, treatment nanoparticle-enhanced post-injury repair. At 15, 30, 60 days post-surgery, the rabbits were humanely euthanized, excised tissue samples fixed 10% formalin histopathological analysis, then processed embedded paraffin microscopic evaluation. Statistical analysis performed SPSS software ANOVA Tukey's post hoc test. Results indicated that supported viability encouraged differentiation chondrocyte-like phenotypes. Scanning Electron Microscopy (SEM) confirmed hydrogels' porosity showed significant differences survival rates compared group, underscoring potential engineering regenerative strategies.

Язык: Английский

Nanoengineered immune check point inhibitors delivery for targeted brain cancer treatment: Current status and future perspectives DOI

Juan Liu,

Yichao Wang,

Zhidu Song

и другие.

Biochemical Pharmacology, Год журнала: 2025, Номер 233, С. 116789 - 116789

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Opportunities for Investing in Organ-on-a-Chip (OoC) Technology, Breast-on-a-Chip (BoC) as an Example Technology Transfer into Islamic Development Bank Members Countries (IsDB-MCs) DOI
Ahmed A. M. Elnour, Nureddin Ashammakhi,

El Bashier Sallam

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Investigation of Silicon Oxide Nanoparticle-Enhanced Self-Healing Hydrogel for Cartilage Repair and Regeneration in Rabbit Earlobe Models DOI
Seyedeh‐Sara Hashemi, Reza Alizadeh, Alireza Rafati

и другие.

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 24

Опубликована: Фев. 28, 2025

This study developed an alginate, gelatin, and chondroitin sulfate hydrogel incorporating silicon oxide nanoparticles to assess morphology, cell proliferation, viability. The effectiveness of these hydrogels for cartilage repair was evaluated in vivo using male albino rabbits, divided into three groups: a control group without hydrogels, observer with lacking nanoparticles, treatment nanoparticle-enhanced post-injury repair. At 15, 30, 60 days post-surgery, the rabbits were humanely euthanized, excised tissue samples fixed 10% formalin histopathological analysis, then processed embedded paraffin microscopic evaluation. Statistical analysis performed SPSS software ANOVA Tukey's post hoc test. Results indicated that supported viability encouraged differentiation chondrocyte-like phenotypes. Scanning Electron Microscopy (SEM) confirmed hydrogels' porosity showed significant differences survival rates compared group, underscoring potential engineering regenerative strategies.

Язык: Английский

Процитировано

0