Investigation of Silicon Oxide Nanoparticle-Enhanced Self-Healing Hydrogel for Cartilage Repair and Regeneration in Rabbit Earlobe Models DOI
Seyedeh‐Sara Hashemi, Reza Alizadeh, Alireza Rafati

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: Feb. 28, 2025

This study developed an alginate, gelatin, and chondroitin sulfate hydrogel incorporating silicon oxide nanoparticles to assess morphology, cell proliferation, viability. The effectiveness of these hydrogels for cartilage repair was evaluated in vivo using male albino rabbits, divided into three groups: a control group without hydrogels, observer with lacking nanoparticles, treatment nanoparticle-enhanced post-injury repair. At 15, 30, 60 days post-surgery, the rabbits were humanely euthanized, excised tissue samples fixed 10% formalin histopathological analysis, then processed embedded paraffin microscopic evaluation. Statistical analysis performed SPSS software ANOVA Tukey's post hoc test. Results indicated that supported viability encouraged differentiation chondrocyte-like phenotypes. Scanning Electron Microscopy (SEM) confirmed hydrogels' porosity showed significant differences survival rates compared group, underscoring potential engineering regenerative strategies.

Language: Английский

Nanoengineered immune check point inhibitors delivery for targeted brain cancer treatment: Current status and future perspectives DOI

Juan Liu,

Yichao Wang,

Zhidu Song

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 233, P. 116789 - 116789

Published: Feb. 1, 2025

Language: Английский

Citations

0
Opportunities for Investing in Organ-on-a-Chip (OoC) Technology, Breast-on-a-Chip (BoC) as an Example Technology Transfer into Islamic Development Bank Members Countries (IsDB-MCs) DOI
Ahmed A. M. Elnour, Nureddin Ashammakhi,

El Bashier Sallam

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Investigation of Silicon Oxide Nanoparticle-Enhanced Self-Healing Hydrogel for Cartilage Repair and Regeneration in Rabbit Earlobe Models DOI
Seyedeh‐Sara Hashemi, Reza Alizadeh, Alireza Rafati

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: Feb. 28, 2025

This study developed an alginate, gelatin, and chondroitin sulfate hydrogel incorporating silicon oxide nanoparticles to assess morphology, cell proliferation, viability. The effectiveness of these hydrogels for cartilage repair was evaluated in vivo using male albino rabbits, divided into three groups: a control group without hydrogels, observer with lacking nanoparticles, treatment nanoparticle-enhanced post-injury repair. At 15, 30, 60 days post-surgery, the rabbits were humanely euthanized, excised tissue samples fixed 10% formalin histopathological analysis, then processed embedded paraffin microscopic evaluation. Statistical analysis performed SPSS software ANOVA Tukey's post hoc test. Results indicated that supported viability encouraged differentiation chondrocyte-like phenotypes. Scanning Electron Microscopy (SEM) confirmed hydrogels' porosity showed significant differences survival rates compared group, underscoring potential engineering regenerative strategies.

Language: Английский

Citations

0