Applied Sciences,
Год журнала:
2024,
Номер
15(1), С. 254 - 254
Опубликована: Дек. 30, 2024
Carrot
(Daucus
carota
L.)
is
a
globally
consumed
root
vegetable,
enjoyed
both
raw
and
after
thermal
processing.
This
study
aimed
to
evaluate
the
effect
of
different
heat
treatment
methods
(traditional
boiling
in
water,
steaming
steel
pot,
combi
oven,
baking
sous-vide
technique)
on
carrot
color,
total
phenolic
flavonoid
content,
carotenoid
compound
profiles,
antioxidant
capacity.
It
was
found
that
treatments
resulted
significant
(p
≤
0.05)
changes
with
reductions
lightness
(L*
decreased
by
19–24%),
redness
(a*
52–67%),
yellowness
(b*
15–25%).
Interestingly,
processed
carrots
showed
an
increase
phenolics
(by
25–133%),
flavonoids
60–126%),
carotenoids
levels
16–48%)
compared
carrots.
However,
specific
compounds
notable
treatment,
including
vanillic
acid
rutin
(100%
reduction
all
treatments),
α-carotene
(up
33.3%
baking),
zeaxanthin
13-cis-β-carotene
40.7%
oven).
In
addition,
significantly
increased
capacity
carrots,
as
determined
DPPH
ABTS
assays,
increases
up
2.2-fold
1.6-fold,
respectively.
The
properties
were
strongly
correlated
content
chlorogenic
acid,
p-coumaric
β-carotene
(r
=
0.86–0.96).
Pharmaceutics,
Год журнала:
2024,
Номер
16(10), С. 1276 - 1276
Опубликована: Сен. 30, 2024
Melanoma
is
a
skin
cancer
that
requires
early
treatment
to
prevent
metastasis.
In
particular,
the
superficial
spreading
melanoma,
excisional
surgery
with
local
administration
of
anti-cancer
drugs
via
microneedles
currently
considered
potential
combination
therapy.
Quercetin
natural
flavonoid
having
activities
against
melanoma
cells.
Unfortunately,
therapeutic
effect
limited
by
its
poor
water
solubility.
Biomedicines,
Год журнала:
2024,
Номер
12(6), С. 1138 - 1138
Опубликована: Май 21, 2024
Diabetic
retinopathy
(DR)
is
one
of
the
most
severe
complications
diabetes
mellitus
and
potentially
leads
to
significant
visual
impairment
blindness.
The
complex
mechanisms
involved
in
pathological
changes
DR
make
it
challenging
achieve
satisfactory
outcomes
with
existing
treatments.
Diets
conducive
glycemic
control
have
been
shown
improve
diabetic
patients,
thus
positioning
dietary
interventions
as
promising
avenues
for
treatment.
Investigations
demonstrated
that
natural
products
(NPs)
may
effectively
manage
DR.
Many
types
compounds,
including
saponins,
phenols,
terpenoids,
flavonoids,
saccharides,
alkaloids,
vitamins,
exert
anti-inflammatory,
antioxidant,
anti-neovascular,
antiapoptotic
effects
vivo
vitro.
Nevertheless,
clinical
application
NPs
still
faces
challenges,
such
suboptimal
specificity,
poor
bioavailability,
a
risk
toxicity.
Prospective
studies
are
imperative
validate
therapeutic
potential
delaying
or
preventing
Molecules,
Год журнала:
2024,
Номер
29(11), С. 2540 - 2540
Опубликована: Май 28, 2024
The
synergistic
effect
of
drug
and
gene
delivery
is
expected
to
significantly
improve
cancer
therapy.
However,
it
still
challenging
design
suitable
nanocarriers
that
are
able
load
simultaneously
anticancer
drugs
nucleic
acids
due
their
different
physico-chemical
properties.
In
the
present
work,
an
amphiphilic
block
copolymer
comprising
a
biocompatible
poly(ethylene
glycol)
(PEG)
multi-alkyne-functional
biodegradable
polycarbonate
(PC)
was
modified
with
number
poly(2-(dimethylamino)ethyl
methacrylate)
(PDMAEMA)
side
chains
applying
highly
efficient
azide–alkyne
“click”
chemistry
reaction.
resulting
cationic
graft
architecture
(MPEG-b-(PC-g-PDMAEMA))
self-associated
in
aqueous
media
into
nanosized
micelles
which
were
loaded
antioxidant,
anti-inflammatory,
quercetin.
drug-loaded
nanoparticles
further
used
form
micelleplexes
through
electrostatic
interactions
DNA.
obtained
nanoaggregates—empty
as
well
intended
for
simultaneous
DNA
codelivery—were
physico-chemically
characterized.
Additionally,
initial
vitro
evaluations
performed,
indicating
potential
application
novel
polymer
systems.
Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1497 - 1497
Опубликована: Ноя. 24, 2024
Tuberculosis
(TB)
is
one
of
the
leading
causes
death
due
to
infectious
disease.
It
a
treatable
disease;
however,
conventional
treatment
requires
lengthy
regimen
with
severe
side
effects,
resulting
in
poor
compliance
among
TB
patients.
Intermittent
drug
use,
non-compliance
patients,
and
prescription
errors,
other
factors,
have
led
emergence
multidrug-resistant
TB,
while
mismanagement
(MDR-TB)
has
eventually
development
extensively
drug-resistant
tuberculosis
(XDR-TB).
Thus,
there
an
urgent
need
for
new
development,
but
enormous
expenses
time
required
(up
20
years)
research
therapeutic
approaches
are
required.
Host-directed
therapies
(HDT)
could
be
most
attractive
strategy,
as
they
target
host
defense
processes
instead
microbe
thereby
may
prevent
alarming
rise
MDR-
XDR-TB.
This
paper
reviews
progress
HDT
using
repurposed
drugs
which
been
investigated
clinical
trials
(completed
or
ongoing)
plant-derived
natural
products
that
preclinical
trial
stages.
Additionally,
this
review
describes
existing
challenges
future
directions
implementation
HDT.
Plants,
Год журнала:
2024,
Номер
13(19), С. 2748 - 2748
Опубликована: Сен. 30, 2024
Sulla
coronaria
is
indigenous
to
the
Mediterranean
region.
It
grown
as
fodder
in
southern
Italy
because
it
contains
various
secondary
metabolites
with
beneficial
activities
on
animals.
Recently,
its
potential
use
cosmeceutical
treatments
for
skin
problems
was
reported.
In
this
scenario,
contribute
a
possible
application,
we
characterized
phytochemical
profile
of
flowers’
hydroalcoholic
extract
by
HPLC-DAD,
Folin-Ciocalteu,
Aluminum
Chloride
methods,
DPPH
assay,
and,
first
time,
evaluated
antioxidant
and
anti-inflammatory
dermal
fibroblasts.
The
analysis
confirmed
significant
content
phenolic
compounds
(TPC
69.8
±
0.6
mg
GAE/g
extract,
TFC
15.07
CE/g
extract)
remarkable
presence
rutin,
quercetin,
isorhamnetin
derivatives
that
give
phytocomplex
good
activity
highlighted
assay
(IC50
8.04
0.5
µg/mL).
Through
reduction
NO•
ROS
levels
human
fibroblasts,
biological
tests
demonstrated
both
safety
ability
counteract
inflammatory
state
generated
Interleukin-1β
exposure.
Our
findings
indicate
are
strictly
related
action
flowers
confirming
plant
could
be
valuable
source
bioactive
molecules
nutraceutical
applications.
Biosensors,
Год журнала:
2024,
Номер
14(9), С. 413 - 413
Опубликована: Авг. 26, 2024
Fisetin
and
Luteolin
are
important
flavonoids
produced
in
plants
known
for
their
antioxidant,
anti-inflammatory,
neuroprotective,
analgesic
properties.
They
also
good
candidates
different
types
of
biosensors.
The
model
used
to
describe
the
fluorescence
(FL)
emission
these
involves
an
excited-state
intermolecular
proton
transfer
(ESIPT)
process
that
causes
a
change
molecule
configuration
corresponding
decrease
energy.
Due
molecular
structures
Luteolin,
only
one
possible
within
is
allowed
each
them:
H3
H5
Luteolin.
Here,
we
compare
calculated
wavelengths,
obtained
using
TDDFT/M06-2X/6-31++G(d,p),
with
FL
spectra
measured
on
powders
solutions
show
experimental
data
consistent
presence
ESIPT
process.
We
wavelengths
found
those
Quercetin,
where,
under
photoexcitation,
transfers
both
protons
possible.
analyze
difference
processes
associated
discuss
reason
predominance
Quercetin.
Additionally,
new
system
notation
flavonoid
molecules
developed.
Nutrients,
Год журнала:
2024,
Номер
16(22), С. 3803 - 3803
Опубликована: Ноя. 6, 2024
Soccer
is
linked
to
an
acute
inflammatory
response
and
the
release
of
reactive
oxygen
species
(ROS).
Antioxidant
supplements
have
shown
promising
effects
in
reducing
muscle
damage
oxidative
stress
enhancing
recovery
process
after
eccentric
exercise.
This
critical
review
highlights
influence
antioxidant
on
performance
following
soccer-related
activity,
training,
or
competition.
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5900 - 5900
Опубликована: Дек. 13, 2024
Quercetin
is
a
natural
polyphenolic
flavonoid
widely
found
in
plants,
fruits,
and
vegetables,
has
been
reported
to
play
pharmacological
roles
numerous
pathogenic
conditions.
The
anti-inflammatory
effects
of
quercetin
various
inflammatory
conditions
diseases
have
well-documented.
However,
its
regulatory
role
noncanonical
inflammasome
activation
not
yet
demonstrated.
This
study
investigated
the
caspase-11
inflammasome-activated
responses
macrophages
mouse
model
acute
lethal
sepsis.
protected
J774A.1
from
lipopolysaccharide
(LPS)-induced
cell
death
inflammasome-induced
pyroptosis.
It
significantly
decreased
production
mRNA
expression
pro-inflammatory
cytokines,
such
as
interleukin
(IL)-1β,
IL-18,
IL-6,
but
tumor
necrosis
factor
(TNF)-α,
molecules,
nitric
oxide
(NO)
inducible
NO
synthase
cells.
Mechanistically,
strongly
suppressed
autoproteolysis
secretion
proteolysis
gasdermin
D
did
inhibit
direct
binding
LPS.
In
vivo,
revealed
that
increased
survival
rate
mice
with
sepsis
serum
levels
cytokines
without
causing
significant
toxicity.
conclusion,
this
highlights
quercetin-mediated
action
through
novel
mechanism
targets
macrophages,
suggesting
promising
agent
medicine.
Metabolites,
Год журнала:
2024,
Номер
15(1), С. 6 - 6
Опубликована: Дек. 31, 2024
In
this
study,
we
present
a
novel
approach
using
amperometric
microsensors
to
detect
quercetin
in
cosmetic
formulations
and
track
its
metabolic
behavior
after
topical
application.
This
method
offers
sensitive,
real-time
alternative
conventional
techniques,
enabling
the
detection
of
quercetin’s
bioavailability,
transformation
into
active
metabolites,
potential
therapeutic
effects
when
applied
skin.
Quercetin
(Q)
is
bioactive
flavonoid
known
for
potent
antioxidant
properties,
naturally
numerous
plants,
particularly
those
with
applications
formulations.
response
growing
interest
developing
plant-based
dermo-cosmetic
solutions,
study
investigates
electrochemical
quercetin,
ketone-type
flavonoid,
extracted
from
Gingko
biloba
essential
oil.
Three
newly
designed
were
developed
assess
their
efficacy
detecting
botanical
samples.
The
sensor
configurations
utilized
two
forms
carbon
material
as
foundation:
graphite
(G)
nanoparticles
(CNs).
These
base
materials
modified
paraffin
oil,
chitosan
(CHIT),
cobalt(II)
tetraphenylporphyrin
(Co(II)TPP)
enhance
sensitivity.
Differential
pulse
voltammetry
(DPV)
served
analytical
investigation.
Among
sensors,
CHIT/G–CN
microsensor
exhibited
highest
sensitivity,
limit
1.22
×
10−7
mol
L−1,
followed
by
G–CN
(5.64
10−8
L−1)
Co(II)TPP/G–CN
(9.80
microsensors.
minimum
detectable
concentration
was
observed
CoP/G–CN
microsensors,
achieving
threshold
low
0.0001
μmol
L−1.
Recovery
rates
relative
standard
deviation
(RSD)
values
averaged
97.4%
±
0.43,
underscoring
sensors’
reliability
matrices.
Applied Sciences,
Год журнала:
2024,
Номер
15(1), С. 254 - 254
Опубликована: Дек. 30, 2024
Carrot
(Daucus
carota
L.)
is
a
globally
consumed
root
vegetable,
enjoyed
both
raw
and
after
thermal
processing.
This
study
aimed
to
evaluate
the
effect
of
different
heat
treatment
methods
(traditional
boiling
in
water,
steaming
steel
pot,
combi
oven,
baking
sous-vide
technique)
on
carrot
color,
total
phenolic
flavonoid
content,
carotenoid
compound
profiles,
antioxidant
capacity.
It
was
found
that
treatments
resulted
significant
(p
≤
0.05)
changes
with
reductions
lightness
(L*
decreased
by
19–24%),
redness
(a*
52–67%),
yellowness
(b*
15–25%).
Interestingly,
processed
carrots
showed
an
increase
phenolics
(by
25–133%),
flavonoids
60–126%),
carotenoids
levels
16–48%)
compared
carrots.
However,
specific
compounds
notable
treatment,
including
vanillic
acid
rutin
(100%
reduction
all
treatments),
α-carotene
(up
33.3%
baking),
zeaxanthin
13-cis-β-carotene
40.7%
oven).
In
addition,
significantly
increased
capacity
carrots,
as
determined
DPPH
ABTS
assays,
increases
up
2.2-fold
1.6-fold,
respectively.
The
properties
were
strongly
correlated
content
chlorogenic
acid,
p-coumaric
β-carotene
(r
=
0.86–0.96).
