Effect of Melatonin on Herpesvirus Type 1 Replication
Опубликована: Фев. 29, 2024
Acute
HSV-1
infection
is
associated
with
mild
symptom,
such
as
fever
and
lesions
of
the
mouth,
face
skin.
This
phase
followed
by
a
latency
period
before
reactivation
which
symptoms
ranging
from
ulcers
to
encephalitis.
Despite
available
anti-HSV-1
drugs,
development
new
antiviral
agents
sought
due
presence
resistant
viruses.
Melatonin,
molecule
secreted
pineal
gland,
has
been
shown
be
an
antioxidant,
inducer
antioxidant
enzymes,
regulator
various
biological
processes.
Clinical
trials
have
explored
its
therapeutic
utility
in
conditions
including
infections.
study
focuses
on
melatonin's
role
replication
underlying
mechanisms.
Melatonin
was
found
decrease
synthesis
proteins
infected
Vero
cells
measured
inmunofluorescence
indicating
inhibition
replication.
Additionally,
it
regulates
activities
enzymes
affects
proteasome
activity.
activates
unfolded
protein
response
(UPR)
autophagy
suppresses
apoptosis
HSV-1-infected
cells.
In
summary,
melatonin
demonstrates
inhibitory
modulating
cellular
responses,
suggesting
potential
treatment
viral
Язык: Английский
Antiviral Effect of Melatonin on Caco-2 Cell Organoid Culture: Trick or Treat?
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 11872 - 11872
Опубликована: Ноя. 5, 2024
Melatonin
is
a
hormone
naturally
produced
by
the
body
that
has
recently
been
found
to
have
antiviral
properties.
However,
its
mechanisms
are
not
entirely
understood.
Using
Caco-2
cells,
we
developed
gastrointestinal
organoid
model
investigate
impact
of
melatonin
on
cellular
culture
response
Poly
I:C-induced
viral
inflammation
in
tract.
was
different
effect
when
applied
as
pretreatment
before
induction
or
treatment
after
it.
I:C
stimulation
did
protect
organoids
from
size
reduction
but
enhanced
cell
proliferation,
especially
lower
(1
and
10
µM)
concentrations
were
used.
On
other
hand,
with
helped
maintain
while
reducing
proliferation.
In
pretreated
reduced
IFNLR1
expression
found,
increased
production
cytokines,
such
IFNλ1
STAT1-3,
prevent
apoptosis.
The
findings
this
study
emphasize
importance
type
III
IFNs
defense
epithelial
cells
shed
more
light
properties
potential
therapeutic
substance.
Язык: Английский