Effect of Melatonin on Herpesvirus Type 1 Replication

Published: Feb. 29, 2024

Acute HSV-1 infection is associated with mild symptom, such as fever and lesions of the mouth, face skin. This phase followed by a latency period before reactivation which symptoms ranging from ulcers to encephalitis. Despite available anti-HSV-1 drugs, development new antiviral agents sought due presence resistant viruses. Melatonin, molecule secreted pineal gland, has been shown be an antioxidant, inducer antioxidant enzymes, regulator various biological processes. Clinical trials have explored its therapeutic utility in conditions including infections. study focuses on melatonin's role replication underlying mechanisms. Melatonin was found decrease synthesis proteins infected Vero cells measured inmunofluorescence indicating inhibition replication. Additionally, it regulates activities enzymes affects proteasome activity. activates unfolded protein response (UPR) autophagy suppresses apoptosis HSV-1-infected cells. In summary, melatonin demonstrates inhibitory modulating cellular responses, suggesting potential treatment viral

Language: Английский

Antiviral Effect of Melatonin on Caco-2 Cell Organoid Culture: Trick or Treat?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11872 - 11872

Published: Nov. 5, 2024

Melatonin is a hormone naturally produced by the body that has recently been found to have antiviral properties. However, its mechanisms are not entirely understood. Using Caco-2 cells, we developed gastrointestinal organoid model investigate impact of melatonin on cellular culture response Poly I:C-induced viral inflammation in tract. was different effect when applied as pretreatment before induction or treatment after it. I:C stimulation did protect organoids from size reduction but enhanced cell proliferation, especially lower (1 and 10 µM) concentrations were used. On other hand, with helped maintain while reducing proliferation. In pretreated reduced IFNLR1 expression found, increased production cytokines, such IFNλ1 STAT1-3, prevent apoptosis. The findings this study emphasize importance type III IFNs defense epithelial cells shed more light properties potential therapeutic substance.

Language: Английский