Applications of dielectrophoresis in microfluidic-based exosome separation and detection
Chemical Engineering Journal,
Год журнала:
2024,
Номер
491, С. 152067 - 152067
Опубликована: Май 9, 2024
Язык: Английский
Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia
Cells,
Год журнала:
2025,
Номер
14(6), С. 409 - 409
Опубликована: Март 11, 2025
Small
extracellular
vesicles
(sEVs),
including
exosomes
as
a
subtype,
with
diameter
typically
less
than
200
nm
and
originating
from
the
endosomal
system,
are
capable
of
transporting
diverse
array
bioactive
molecules,
proteins,
nucleic
acids,
lipids,
thereby
facilitating
intercellular
communication
modulating
cellular
functions.
Vascular
dementia
(VaD)
represents
form
cognitive
impairment
attributed
to
cerebrovascular
disease,
characterized
by
complex
multifaceted
pathophysiological
mechanism.
Currently,
therapeutic
approach
VaD
predominantly
emphasizes
symptom
management,
no
specific
pharmacological
treatment
exists
cure
condition.
Recent
investigations
have
illuminated
significant
role
sEVs
in
pathogenesis
vascular
dementia.
This
review
seeks
provide
comprehensive
analysis
characteristics
functions
sEVs,
particular
focus
on
their
involvement
its
underlying
mechanisms.
The
objective
is
advance
understanding
interplays
between
dementia,
offering
novel
insights
for
future
research
strategies.
Язык: Английский
Recent Advances in Microfluidic-Based Extracellular Vesicle Analysis
Опубликована: Март 13, 2024
Extracellular
vesicles
(EVs)
hold
enormous
potential
in
the
diagnosis
and
treatment
of
diseases,
benefit
from
their
roles
intercellular
signaling,
as
well
plentiful
presence
stability
body
fluids.
However,
conventional
EV
isolation
methods
are
labor-intensive,
harvest
EVs
with
low
purity
compromised
recovery.
In
addition,
drawbacks,
such
limited
sensitivity
specificity
traditional
analysis
hinder
application
clinical
use.
Therefore,
it
is
urgent
to
develop
effective
standardized
for
isolating
detecting
EVs.
Microfluidics
technology
a
powerful
rapidly
developing
that
has
been
introduced
solution
above
bottlenecks.
It
holds
advantages
high
integration,
short
time,
consumption
samples
reagents.
this
review,
we
summarize
techniques
alongside
microfluidic-based
methodologies
detection
We
emphasize
separation
microfluidic
enhancing
capture
efficiency
precise
targeting,
while
summarizing
its
analytical
role
targeted
discussing
significance
tumor
microenvironment,
providing
direction
achieving
automated
high-throughput
samples.
Язык: Английский