Recent Advances in Microfluidic-Based Extracellular Vesicle Analysis DOI Open Access
Jiming Chen, Meiyu Zheng,

Qiaoling Xiao

et al.

Published: March 13, 2024

Extracellular vesicles (EVs) hold enormous potential in the diagnosis and treatment of diseases, benefit from their roles intercellular signaling, as well plentiful presence stability body fluids. However, conventional EV isolation methods are labor-intensive, harvest EVs with low purity compromised recovery. In addition, drawbacks, such limited sensitivity specificity traditional analysis hinder application clinical use. Therefore, it is urgent to develop effective standardized for isolating detecting EVs. Microfluidics technology a powerful rapidly developing that has been introduced solution above bottlenecks. It holds advantages high integration, short time, consumption samples reagents. this review, we summarize techniques alongside microfluidic-based methodologies detection We emphasize separation microfluidic enhancing capture efficiency precise targeting, while summarizing its analytical role targeted discussing significance tumor microenvironment, providing direction achieving automated high-throughput samples.

Language: Английский

Applications of dielectrophoresis in microfluidic-based exosome separation and detection DOI
Lan Mei, Fang Yang

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 491, P. 152067 - 152067

Published: May 9, 2024

Language: Английский

Citations

11
Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia DOI Creative Commons

Yujie Yang,

Chunchu Deng,

Fatima Aldali

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 409 - 409

Published: March 11, 2025

Small extracellular vesicles (sEVs), including exosomes as a subtype, with diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting diverse array bioactive molecules, proteins, nucleic acids, lipids, thereby facilitating intercellular communication modulating cellular functions. Vascular dementia (VaD) represents form cognitive impairment attributed to cerebrovascular disease, characterized by complex multifaceted pathophysiological mechanism. Currently, therapeutic approach VaD predominantly emphasizes symptom management, no specific pharmacological treatment exists cure condition. Recent investigations have illuminated significant role sEVs in pathogenesis vascular dementia. This review seeks provide comprehensive analysis characteristics functions sEVs, particular focus on their involvement its underlying mechanisms. The objective is advance understanding interplays between dementia, offering novel insights for future research strategies.

Language: Английский

Citations

0
Recent Advances in Microfluidic-Based Extracellular Vesicle Analysis DOI Open Access
Jiming Chen, Meiyu Zheng,

Qiaoling Xiao

et al.

Published: March 13, 2024

Extracellular vesicles (EVs) hold enormous potential in the diagnosis and treatment of diseases, benefit from their roles intercellular signaling, as well plentiful presence stability body fluids. However, conventional EV isolation methods are labor-intensive, harvest EVs with low purity compromised recovery. In addition, drawbacks, such limited sensitivity specificity traditional analysis hinder application clinical use. Therefore, it is urgent to develop effective standardized for isolating detecting EVs. Microfluidics technology a powerful rapidly developing that has been introduced solution above bottlenecks. It holds advantages high integration, short time, consumption samples reagents. this review, we summarize techniques alongside microfluidic-based methodologies detection We emphasize separation microfluidic enhancing capture efficiency precise targeting, while summarizing its analytical role targeted discussing significance tumor microenvironment, providing direction achieving automated high-throughput samples.

Language: Английский

Citations

3