Fabrication and Evaluation of Dissolving Hyaluronic Acid Microneedle Patches for Minimally Invasive Transdermal Drug Delivery by Nanoimprinting

Gels, Год журнала: 2025, Номер 11(2), С. 89 - 89

Опубликована: Янв. 23, 2025

Transdermal drug delivery minimizes pain and provides a controlled, stable release of drugs, but its effectiveness is limited by the skin’s natural barriers. Microneedles overcome this problem, enabling minimally invasive delivery. Microneedle patches (MNPs) with 80 µm-tall needles composed hyaluronic acid (HA) were developed evaluated for their formability, structural integrity, dissolution rate, skin penetration ability, transmission capacity. The influence molecular weight HA on these properties was also investigated. MNPs made from low-molecular-weight (30 kDa–50 kDa) demonstrated 12.5 times superior permeability in ex vivo human compared to needleless (NLPs). Furthermore, same test, had 1.7 higher than high-molecular-weight MNPs, suggesting transdermal administration. significantly influenced solubility permeability, highlighting potential as systems. Puncture tests depth 50–60 µm, indicating minimal nerve irritation dermis effective superficial dermal layer. These results present manufacturing technique incorporating model compounds highlight novel method biomedical applications soft gels.

Язык: Английский

Determination of vat-photopolymerization parameters for microneedles fabrication and characterization of HPMC/PVP K90 dissolving microneedles utilizing 3D-printed mold

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 13, 2024

Three-dimensional (3D) printing serves as an alternative method for fabricating microneedle (MN) patches with a high object resolution. In this investigation, four distinct needle shapes: pyramid mounted over long cube (shape A), cone cylinder B), pyramidal shape C), and conical D) were designed using computer-aided design (CAD) software compensated bases of 350, 450 550 µm. Polylactic acid (PLA) biophotopolymer resin from eSun stereolithography (SLA) 3D printer Anycubic technology used to print MN patches. The 3D-printed employed construct molds, those molds produce hydroxypropyl methylcellulose (HPMC) polyvinyl pyrrolidone (PVP) K90 dissolving microneedles (DMNs). Various parameters, such curing time, angle, anti-aliasing (AA), varied evaluate suitable conditions each shape. Furthermore, physical appearance, mechanical property, skin insertion ability HPMC/PVP DMNs examined. results showed that A C, the time angle 1.5 s 30° while shapes B D, they 2.0 45°, respectively. All required AA eliminate their stair-stepped edges. Additionally, it was demonstrated all twelve designs could be molds. needles exhibited better physicochemical properties compared C D. Particularly, both sample 9 10 displayed sharp without bent tips, coupled minimal height reduction (< 10%) percentage blue dots (approximately 100%). As result, can utilized custom producing manufactured by excellent properties.

Язык: Английский

Development of Polylactic Acid Microneedles for Enhanced Transdermal Delivery of Desmopressin Peptides: A Computational Study

Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 103777 - 103777

Опубликована: Апрель 1, 2025

Язык: Английский