Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 143 - 168
Опубликована: Ноя. 29, 2024
Язык: Английский
GeroScience, Год журнала: 2024, Номер unknown
Опубликована: Июль 26, 2024
Abstract Biological age (BA) captures detrimental age-related changes. The best-known and most-used BA indicators include DNA methylation–based epigenetic clocks telomere length (TL). most common biological sample material for epidemiological aging studies, whole blood, is composed of different cell types. We aimed to compare differences in BAs between blood types assessed the indicators’ type-specific associations with chronological (CA). An analysis indicators, including TL, methylation level at cg16867657 ELOVL2 , as well Hannum, Horvath, DNAmPhenoAge, DunedinPACE clocks, was performed on 428 samples 12 values were majority pairwise comparisons types, comparison ( p < 0.05). DNAmPhenoAge showed largest type differences, up 44.5 years methylation-based TL lowest differences. T cells generally had "youngest" values, across subsets, whereas monocytes "oldest" values. All except DunedinPACE, strongly correlated CA within a type. Some such DNAmPhenoAge-difference naïve CD4 + constant regardless donor's (range 20–80 years), while they not. In conclusion, exhibit type–specific characteristics. Our results have implications understanding molecular mechanisms underlying underscore importance considering composition when utilizing them success interventions.
Язык: Английский
Процитировано
4
Tissue and Cell, Год журнала: 2025, Номер 93, С. 102723 - 102723
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
0
Disability and Rehabilitation, Год журнала: 2025, Номер unknown, С. 1 - 22
Опубликована: Фев. 7, 2025
To investigate how different sets of rehabilitation programs can contribute to breaking the frailty cycle. Systematic review with meta-analysis randomized controlled trials that investigated effects for adults FS. Search references on Embase, PEDro, SciELO, Web Of Science, Pubmed, EBSCO and Scopus, published until September 2024. Methodological quality was assessed PEDro scale, risk bias ROB 2.0, certainty evidence GRADE approach. Thirty-four studies (34) were included, high methodological a low bias. There is significant able improve performance in activities daily living (SMD = 0.83; 95%CI: 0.26, 1.40; p 0.004; certainty), lower extremity function mobility 0.63; 0.40, 0.86; < 0.001; moderate certainty) gait speed 1.07; 0.17, 1.97; 0.002; reducing score -1.57; -2.97, -0.17; ≤ very prevalence (RR 0.76; 0.65, 0.89; 0.006; minimal no reports adverse effects. Rehabilitation consisting multicomponent moderate-intensity physical exercise associated nutritional monitoring, cognitive training, educational strategies, medical social support are effective break cycle.Implications rehabilitationRehabilitation older people prevent reverse pre-frailty.Performance, mobility, strength programs.Rehabilitation professionals should considerer these key components when designing frail pre-frail people: exercises, nutrition, training.Rehabilitation be aware adherence main barrier peoples programs.
Язык: Английский
Процитировано
0
Therapeutic Advances in Musculoskeletal Disease, Год журнала: 2023, Номер 15
Опубликована: Янв. 1, 2023
‘Frailty’ has been described as ‘a state of increased vulnerability the individual caused by an impairment homeostasis a result endogenous or exogenous stress’. Frail individuals are depicted dramatic change in health status following apparently minor insult and higher risk adverse health-related outcomes such osteoporosis sarcopenia, falls disability, fragility fractures. Frailty is condition increasing importance due to global ageing population during last decades. Central pathophysiology frailty mechanism that partially independent ageing, but most likely evolves with ageing: cumulative level molecular cellular damage every subject. Furthermore, uncorrected nutrition sedentary behaviour play pivotal role worsening syndrome. In January 2020, cluster genus family Coronaviridae was isolated pathogen new coronavirus disease (COVID-19). Since then, this infection spread worldwide causing one pandemics modern era, more than 500 million confirmed cases all over world. The clinical spectrum SARS-CoV-2 severity ranges from asymptomatic conditions mild symptoms, fever, cough, ageusia, anosmia asthenia, up severe conditions, acute respiratory distress syndrome (ARDS) multi-organ failure leading death. Primary evidence revealed elderly frail subjects were susceptible its intense form at greater developing COVID-19. Factors contributing COVID-19, mortality rate, poor immune system activity long-standing inflammatory compared general population. Further recent research also suggested potential behaviour, metabolic chronic disorders linked it nutritional status. Thus, aim review evaluate different studies related COVID-19 pandemic, both physical activity, and, also, provide further information on correct approach peculiar pathological condition.
Язык: Английский
Процитировано
10
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Апрель 9, 2024
The notion that viruses played a crucial role in the evolution of life is not new concept. However, more recent insights suggest this perception might be even expansive, highlighting ongoing impact on host evolution. Endogenous retroviruses (ERVs) are considered genomic remnants ancient viral infections acquired throughout vertebrate Their exogenous counterparts once infected host's germline cells, eventually leading to permanent endogenization their respective proviruses. success ERV colonization evident so it constitutes 8% human genome. Emerging studies indicate endogenous merely past but rather play corollary role, despite fully understood, genetic regulation. This review presents some evidence supporting regulating genetics. We explore involvement ERVs (HERVs) key physiological processes, from precise and orchestrated activities during cellular differentiation pluripotency contributions aging senescence. Additionally, we discuss costs associated with hosting substantial amount preserved material.
Язык: Английский
Процитировано
2
BioScience Trends, Год журнала: 2023, Номер 17(4), С. 262 - 270
Опубликована: Авг. 22, 2023
As people age, geriatric syndromes characterized by frailty significantly impact both clinical practice and public health. Aging weakens people's immune functions, leading to chronic low-grade inflammation that ultimately contributes the development of frailty. Effectively managing can help alleviate economic burden an aging population. This review delves into intricate relationship among aging, infection-induced inflammation, In addition, it analyzes various approaches interventions address frailty, such as smart rehabilitation programs stem-cell treatments, offering promising solutions in this new era. Given importance topic, further research mechanisms is crucial. Equally essential devising relevant measures delay its onset formulation comprehensive clinical, research, health strategies enhance quality life for elderly individuals.
Язык: Английский
Процитировано
6
Age and Ageing, Год журнала: 2024, Номер 53(Supplement_2), С. ii1 - ii3
Опубликована: Май 1, 2024
Язык: Английский
Процитировано
2
World Journal of Urology, Год журнала: 2024, Номер 42(1)
Опубликована: Май 15, 2024
Abstract Purpose This study aimed to assess the effect of modified 5-item frailty index on perioperative complications and surgical outcomes in patients who underwent ureteroscopy with laser lithotripsy for upper urinary tract stones. Methods Patients stones between 2019 2022 were reviewed retrospectively. Assessment was performed using based medical history (hypertension, diabetes, heart failure, chronic obstructive pulmonary disease) functional status. categorized into high (≥ 2) low (≤ 1) groups score. We compared two groups. Results Seventy-one (15.8%) 393 (84.1%) 467 classified groups, respectively. The group exhibited a significant association increased febrile infections [≥ 37.8 °C: 15 (20.3%) vs 13 (3.3%), p < 0.001; ≥ 38 9 (12.2%) 7 (1.8%), 0.001]. Surgical outcomes, including operative time stone-free rate, did not differ significantly Conclusion is valuable predicting postoperative complications, particularly infections, after allows practical preoperative risk assessment lithotripsy.
Язык: Английский
Процитировано
2
Nutrients, Год журнала: 2024, Номер 16(19), С. 3359 - 3359
Опубликована: Окт. 2, 2024
Background/Objectives: We have previously described that low adherence to the Mediterranean diet (MD) in elderly patients admitted internal medicine wards is linked poorer clinical outcomes. This investigation was designed explore whether MD related circulating markers of redox balance and inflammation this scenario. Methods: A cross-sectional study performed on 306 acute old hospitalized wards. Adherence estimated by Italian Index (IMI). The were assessed serum erythrocytes correlated with inflammatory across different groups. Results: Compared high adherence, those exhibited severely impaired balance, as evidenced a higher GSSG/GSH ratio increased hydroxynonenal/malondialdehyde–protein adducts. No modifications expression antioxidant enzymes peripheral blood mononuclear cells. Patients neutrophil-to-lymphocyte systemic inflammation, well raised levels interleukin-6 tumor necrosis factor, compared adherence. strong association observed between inflammation/immune response, highest regression coefficients found group. Conclusions: Old display unfavorable profiles inflammation. It conceivable such effects can be polyphenol content MD. supports rationale for intervention trials attest effectiveness nutritional strategy disease prevention.
Язык: Английский
Процитировано
1
Frontiers in Neurology, Год журнала: 2024, Номер 15
Опубликована: Окт. 9, 2024
We investigated the potential relationship between age-related conditions, particularly sarcopenia and ischemic stroke (IS), through a two-sample Mendelian randomization (MR) study.
Язык: Английский
Процитировано
1