International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6083 - 6083
Опубликована: Май 31, 2024
Ferroptosis,
which
comprises
iron-dependent
cell
death,
is
crucial
in
cancer
and
non-cancer
treatments.
Exosomes,
the
extracellular
vesicles,
may
deliver
biomolecules
to
regulate
disease
progression.
The
interplay
between
ferroptosis
exosomes
modulate
development
but
rarely
investigated
natural
product
treatments
their
modulating
miRNAs.
This
review
focuses
on
ferroptosis-modulating
effects
of
products
miRNAs
concerning
participation
exosome
biogenesis
(secretion
assembly)-related
targets
cells.
Natural
with
were
retrieved
organized.
Next,
a
literature
search
established
connection
panel
genes
these
ferroptosis-associated
products.
Moreover,
inputted
into
miRNA
database
(miRDB)
bioinformatically
potential
for
modulation
biogenesis.
Finally,
provided
Consequently,
connections
from
ferroptosis–miRNA–exosome
product-based
anticancer
are
well-organized.
sheds
light
research
directions
integrating
therapeutic
diseases.
Cell Death Discovery,
Год журнала:
2023,
Номер
9(1)
Опубликована: Июнь 27, 2023
Abstract
Ferroptosis,
a
novel
mode
of
cell
death
dependent
on
iron
and
reactive
oxygen
species,
has
been
extensively
explored
during
malignant
tumors
metastasis.
Ferroptosis
can
interact
with
multiple
components
the
tumor
microenvironment
to
regulate
These
interactions
generally
include
following
aspects:
(1)
Epithelial-mesenchymal
transformation,
which
help
cancer
cells
increase
their
sensitivity
ferroptosis
while
they
have
mechanisms
fight
against
it;
(2)
Disorder
metabolism
in
stem
maintains
characteristics;
(3)
Polarization
M0
macrophages
M2.
(4)
The
paradoxical
effects
CD8
+
T
induced
by
(5)
Regulation
angiogenesis.
In
addition,
be
regulated
miRNAs
through
reprogramming
various
intracellular
processes,
including
regulation
glutathione-
glutathione
peroxidase
4
pathway,
glutamic
acid/cystine
transport,
metabolism,
lipid
oxidative
stress.
Therefore,
there
are
many
potential
between
ferroptosis-related
metastasis,
interaction
immune
cells,
regulating
cytokines,
This
review
focuses
role
miRNA
aiming
readers
understand
relationship
provide
new
perspective
treatment
strategies
tumors.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Май 19, 2023
Hepatocellular
carcinoma
(HCC)
has
developed
into
one
of
the
most
lethal,
aggressive,
and
malignant
cancers
worldwide.
Although
HCC
treatment
improved
in
recent
years,
incidence
lethality
continue
to
increase
yearly.
Therefore,
an
in-depth
study
pathogenesis
search
for
more
reliable
therapeutic
targets
are
crucial
improving
survival
quality
patients.
Currently,
miRNAs
have
become
hotspots
life
science
research,
which
widely
present
living
organisms
non-coding
RNAs
involved
regulating
gene
expression.
MiRNAs
exert
their
biological
roles
by
suppressing
expression
downstream
genes
engaged
various
HCC-related
processes,
including
proliferation,
apoptosis,
invasion,
metastasis.
In
addition,
status
is
related
drug
resistance
mechanism
HCC,
important
implications
systemic
HCC.
This
paper
reviews
regulatory
role
clinical
applications
years.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 23, 2023
Regulated
cell
death
(RCD)
is
a
strategy
employed
by
host
cells
to
defend
invasions
of
pathogens,
such
as
viruses
and
bacteria.
Ferroptosis
type
RCD
characterized
excessive
accumulation
iron
lipid
peroxidation.
While
ferroptosis
primarily
considered
mechanism
associated
with
tumorigenesis,
emerging
evidence
begin
suggest
that
it
may
play
essential
role
during
virus
infections.
Recent
studies
illustrated
activation
could
either
induce
or
prohibit
various
types
RCDs
facilitate
replication
evade
surveillance.
More
experimental
has
demonstrated
how
regulate
influence
replication,
transmission,
pathogenesis.
This
review
summarizes
ferroptosis-related
metabolism,
including
peroxidation,
antioxidant
metabolism.
Furthermore,
we
discuss
the
interplay
between
viral
infections
process,
focus
on
exploit
for
its
own
replication.
Understanding
impacts
infection
can
offer
valuable
insights
into
development
effective
therapeutic
strategies
combat
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6083 - 6083
Опубликована: Май 31, 2024
Ferroptosis,
which
comprises
iron-dependent
cell
death,
is
crucial
in
cancer
and
non-cancer
treatments.
Exosomes,
the
extracellular
vesicles,
may
deliver
biomolecules
to
regulate
disease
progression.
The
interplay
between
ferroptosis
exosomes
modulate
development
but
rarely
investigated
natural
product
treatments
their
modulating
miRNAs.
This
review
focuses
on
ferroptosis-modulating
effects
of
products
miRNAs
concerning
participation
exosome
biogenesis
(secretion
assembly)-related
targets
cells.
Natural
with
were
retrieved
organized.
Next,
a
literature
search
established
connection
panel
genes
these
ferroptosis-associated
products.
Moreover,
inputted
into
miRNA
database
(miRDB)
bioinformatically
potential
for
modulation
biogenesis.
Finally,
provided
Consequently,
connections
from
ferroptosis–miRNA–exosome
product-based
anticancer
are
well-organized.
sheds
light
research
directions
integrating
therapeutic
diseases.
