Mitochondrial signaling pathways and their role in cancer drug resistance
Cellular Signalling,
Год журнала:
2024,
Номер
122, С. 111329 - 111329
Опубликована: Авг. 5, 2024
Язык: Английский
N‐acetylcysteine for the Prevention of Cisplatin‐Induced Hearing Loss: A Systematic Review and Meta‐analysis
Otolaryngology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
Abstract
Objective
Cisplatin
is
an
effective
antineoplastic
drug
used
worldwide
in
the
treatment
of
various
malignancies.
However,
it
associated
with
side
effects,
including
cisplatin‐induced
hearing
loss
(CIHL).
N‐acetylcysteine
(NAC)
has
been
suggested
as
a
promising
to
prevent
or
reduce
cisplatin‐derived
ototoxicity.
To
evaluate
evidence
supporting
efficacy
NAC
preventing
CIHL,
we
conducted
systematic
review
and
meta‐analysis
literature.
Data
Sources
A
search
was
on
PubMed,
Embase,
Web
Science,
Clinicaltrials.gov
,
Cochrane
Library.
Review
Methods
Articles
reporting
administration
systemic
transtympanic
injection
for
CIHL
prevention
were
considered.
The
outcomes
interest
included
presence
events
changes
thresholds
at
0.5
through
12
kHz
following
cisplatin
treatment.
Results
total
7
studies
involving
217
patients
met
inclusion
criteria.
Of
these
patients,
175
received
NAC,
remaining
NAC.
No
significant
differences
found
between
use
either
compared
placebo
(risk
ratio
[RR]
0.80;
95%
confidence
interval
[CI]
0.54‐1.19;
P
=
.28,
RR
0.89;
CI
0.51‐1.54;
.67,
respectively).
8
groups.
Qualitative
analyses
tendency
otoprotection
ultra‐high
frequencies
(10
kHz).
Conclusion
Our
findings
suggest
that,
regardless
route,
current
published
does
not
show
that
standard
clinical
audiogram
range.
Further
larger
samples
are
needed
confirm
our
findings.
Level
Evidence
I.
Язык: Английский
Evaluating N-acetylcysteine for mitigating cisplatin-induced oxidative stress and ionocyte damage in a zebrafish model
Toxicology and Applied Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 117401 - 117401
Опубликована: Май 1, 2025
Язык: Английский
Leonurine protects against cisplatin-induced ototoxicity through its anti-oxidation and anti-apoptosis properties
Toxicology Letters,
Год журнала:
2025,
Номер
410, С. 1 - 15
Опубликована: Май 22, 2025
Язык: Английский
Neuroprotective mechanisms and ameliorative activities of quercetin in cisplatin-induced cerebellum neurotoxicity in rat models
Brain Disorders,
Год журнала:
2024,
Номер
unknown, С. 100166 - 100166
Опубликована: Окт. 1, 2024
Язык: Английский
Importance of Selected Antioxidants in Carcinogenesis and Cancer Therapy
Interdisciplinary cancer research,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Heterogeneous nuclear ribonucleoprotein K is a potential target for enhancing the chemosensitivity of nasopharyngeal carcinoma
Open Life Sciences,
Год журнала:
2024,
Номер
19(1)
Опубликована: Янв. 1, 2024
Abstract
The
resistance
of
tumor
cells
to
chemotherapy
drugs
is
a
critical
determinant
in
the
recurrence
and
metastasis
nasopharyngeal
carcinoma
(NPC).
Therefore,
it
crucial
identify
effective
biotargets
that
can
enhance
sensitivity
NPC
drugs.
Heterogeneous
nuclear
ribonucleoprotein
K
(hnRNPK)
plays
central
role
regulating
across
various
types.
However,
its
specific
function
remains
unclear.
This
study
reveals
hnRNPK
overexpressed
tissues
while
weakly
expressed
normal
tissues.
expression
level
negatively
associated
with
patient
survival.
Importantly,
key
inducer
NPC,
as
evidenced
by
significant
increase
cell
cisplatin
following
knockdown.
Mechanistically,
induces
suppressing
activation
Akt/caspase
3
pathway.
In
tumor-bearing
mice,
knockdown
enhances
efficacy
chemotherapy.
Consequently,
this
work
identifies
potential
target
for
enhancing
Язык: Английский
Renogrit selectively protects against cisplatin-induced injury in human renal tubular cells and in Caenorhabditis elegans by harmonizing apoptosis and mitophagy
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Авг. 21, 2024
Cisplatin-induced
nephrotoxicity
restricts
its
clinical
use
against
solid
tumors.
The
present
study
elucidated
the
pharmacological
effects
of
Renogrit,
a
plant-derived
prescription
medicine,
using
cisplatin-induced
human
renal
proximal
tubular
(HK-2)
cells
and
Caenorhabditis
elegans.
Quantification
phytochemicals
in
Renogrit
was
performed
on
HPTLC
UHPLC
platforms.
assessed
vitro
HK-2
post-exposure
to
clinically
relevant
concentration
cisplatin.
It
observed
that
renoprotective
properties
injury
stem
from
ability
regulate
markers
(KIM-1,
NAG
levels;
NGAL
mRNA
expression),
redox
imbalance
(ROS
generation;
GST
levels),
mitochondrial
dysfunction
(mitochondrial
membrane
potential;
SKN-1,
HSP-60
expression).
also
found
modulate
apoptosis
(EGL-1
expression;
protein
levels
p-ERK,
p-JNK,
p-p38,
c-PARP1),
necroptosis
(intracellular
calcium
accumulation;
RIPK1,
RIPK3,
MLKL
mitophagy
(lysosome
population;
expression
PINK1,
PDR1;
p-PINK1,
LC3B),
inflammation
(IL-1β
activity;
LXR-α).
More
importantly,
treatment
did
not
hamper
normal
anti-proliferative
cisplatin
as
cytotoxicity
analysis
MCF-7,
A549,
SiHa,
T24
cancer
cells.
Taken
together,
could
be
potential
candidate
mitigate
without
compromising
anti-neoplastic
Язык: Английский