Polymers,
Год журнала:
2024,
Номер
16(18), С. 2564 - 2564
Опубликована: Сен. 11, 2024
The
primary
objective
of
this
systematic
review
study
was
to
investigate
the
effectiveness,
durability,
and
adverse
events
PLLA
treatment
for
aesthetic
indications.
search
strategy
performed
in
MEDLINE
(Ovid).
electronic
literature
five
databases
performed,
from
inception
until
12th
February
2024.
This
identify
randomized
clinical
trials
that
assessed
adult
individuals
exhibiting
facial
aging
and/or
lipoatrophy.
Risk
bias
using
Cochrane
Risk-of-Bias
Tool
Randomized
Trials
(RoB
2).
Eleven
RCTs
out
1467
identified
citations
were
included.
Four
studies
showed
increased
dermal
thickness,
significant
improvement
lipoatrophy
severity
scores,
after
with
its
effects
sustained
at
least
25
months.
Two
demonstrated
superiority
over
injectable
human
collagen.
Also,
three
positive
results
favoring
when
compared
PH
gel
severity,
transepidermal
water
loss,
skin
quality,
elasticity,
patient
satisfaction.
All
mild-to-moderate
intensity,
main
ones
worth
noting
bruising,
hematoma,
tenderness,
nodules,
edema.
Five
eleven
considered
having
high
risk
bias.
evidence
on
effectiveness
safety
rejuvenation
is
low
quality;
thus,
reported
safety,
long-lasting
purpose
should
be
further
investigated.
Journal of Cosmetic Dermatology,
Год журнала:
2025,
Номер
24(6)
Опубликована: Май 29, 2025
ABSTRACT
Background
Calcium
hydroxyapatite
(CaHA)
fillers
are
widely
used
for
soft‐tissue
augmentation
due
to
their
volumizing
properties
and
biostimulatory
effects.
However,
clinical
evidence
supporting
the
dual
role
of
CaHA
as
both
a
volumizer
skin
booster
remains
limited.
Objectives
To
evaluate
efficacy
filler
(VoLassom)
in
midface
volume
restoration
assess
its
effects
on
barrier
function,
hydration,
elasticity
over
24
weeks.
Methods
Fifteen
participants
aged
19–70
years
with
moderate
deficiency
(Midface
Volume
Deficiency
Scale
[MFVDS]
grade
≥
3)
received
injections.
Clinical
assessments
included
MFVDS
scoring,
Global
Aesthetic
Improvement
(GAIS),
patient
satisfaction
ratings
at
baseline
weeks
2,
4,
24.
Instrumental
evaluations
transepidermal
water
loss
(TEWL),
corneometer‐based
cutometer‐measured
(R2,
R5,
R7)
were
conducted
all
timepoints.
Results
scores
significantly
decreased
from
24,
demonstrating
sustained
restoration.
GAIS
remained
high,
rated
improved
(5.0)
2
though
slightly
reduced
week
(4.53
±
0.52).
Patient
consistently
high.
TEWL
4
(
p
<
0.01),
indicating
function.
Corneometer
measurements
showed
significant
hydration
improvements
timepoints
0.05
0.001,
respectively).
Skin
elasticity,
measured
by
R2,
R7,
increased
suggesting
enhanced
firmness.
Conclusions
demonstrated
effective
while
improving
elasticity.
These
findings
suggest
that
functions
not
only
but
also
booster,
offering
comprehensive
approach
facial
rejuvenation.
Nevertheless,
further
studies
larger
cohorts
warranted
validate
these
results.
Journal of Cosmetic Dermatology,
Год журнала:
2022,
Номер
22(4), С. 1213 - 1219
Опубликована: Дек. 27, 2022
Poly-L-Lactic
Acid
(PLLA)
is
a
synthetic
polymer
which
possesses
biocompatible
and
biodegradable
properties,
widely
used
in
the
clinical
filler
material.
This
study
focuses
on
potential
role
of
PLLA
collagen
production
dermal
fibroblasts
its
mechanism.The
fibroblast
Hs60
was
treated
with
different
concentration
PLLA.
RT-qPCR
conducted
for
determination
mRNA
levels
type
I
(COL1)
alpha
1
(COL1A1),
COL1
2
(COL1A2),
elastin,
matrix
metalloproteinase
(MMP-1),
tissue
inhibitor
(TIMP-1),
TIMP-2.
Procollagen
Type
C-peptide
(PIP)
enzyme
immunoassay
(EIA)
Kit
assay
carried
out
to
analyze
procollagen
production.
Western
Blot
employed
examine
effect
transforming
frown
factor
(TGF-β)
receptor-specific
(SB431542)
protein
COL1A1
TGF-β/Smad
signaling
pathway
related
proteins.With
increase
concentration,
gradually
increased,
both
COL1A2
increased
(p
<
0.001).
Elevated
concentrations
TIMP-1,
TIMP-2
attenuated
MMP-1
expression.
TGF-β
dose-dependently
manner.
p-Smad2
p-Smad3
were
also
by
PLLA,
but
influences
reversed
SB431542
Similarly,
COL1A1,
COL1A2,
caused
significantly
inhibited
SB431542,
whereas
typically
elevated
0.001).Poly-L-Lactic
promotes
activating
pathway.
The
findings
may
lay
foundation
material
applications
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2564 - 2564
Опубликована: Сен. 11, 2024
The
primary
objective
of
this
systematic
review
study
was
to
investigate
the
effectiveness,
durability,
and
adverse
events
PLLA
treatment
for
aesthetic
indications.
search
strategy
performed
in
MEDLINE
(Ovid).
electronic
literature
five
databases
performed,
from
inception
until
12th
February
2024.
This
identify
randomized
clinical
trials
that
assessed
adult
individuals
exhibiting
facial
aging
and/or
lipoatrophy.
Risk
bias
using
Cochrane
Risk-of-Bias
Tool
Randomized
Trials
(RoB
2).
Eleven
RCTs
out
1467
identified
citations
were
included.
Four
studies
showed
increased
dermal
thickness,
significant
improvement
lipoatrophy
severity
scores,
after
with
its
effects
sustained
at
least
25
months.
Two
demonstrated
superiority
over
injectable
human
collagen.
Also,
three
positive
results
favoring
when
compared
PH
gel
severity,
transepidermal
water
loss,
skin
quality,
elasticity,
patient
satisfaction.
All
mild-to-moderate
intensity,
main
ones
worth
noting
bruising,
hematoma,
tenderness,
nodules,
edema.
Five
eleven
considered
having
high
risk
bias.
evidence
on
effectiveness
safety
rejuvenation
is
low
quality;
thus,
reported
safety,
long-lasting
purpose
should
be
further
investigated.
