The role of obesity in sarcopenia and the optimal body composition to prevent against sarcopenia and obesity

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Март 1, 2023

Background Elderly people with low lean and high fat mass, are diagnosed sarcopenic obesity (SO), often have poor clinical outcomes. This study aimed to explore the relationship between sarcopenia, optimal proportion of muscle for old individuals. Methods Participants aged 60 years or above were instructed perform bioelectrical impedance analysis obtain indicators, handgrip strength was also performed. Sarcopenia according predicted appendicular skeletal mass function. Body index (BMI) body percentage (BF%) used define obesity. The association indicators analyzed by Pearson’s correlation coefficient. Pearson Chi-Square test utilized estimate odds ratios (OR) 95% confidence intervals (CI) on risk sarcopenia status. Results 1637 subjects (74.8 ± 7.8 years) participated in this study. Not only but positively correlated BMI weight (p < 0.05). Absolute different positions had positive associations Muscle negatively related When defined (OR = 0.69, CI [0.56, 0.86]; p 0.001), a protective factor whilst it when using BF% 1.38, [1.13, 1.69]; 0.002) as definition. reduced increase both genders. It increased raised males displayed U-shaped curve females. 26.0–34.6% females lower than 23.9% recommended prevention. Conclusion Skeletal strong absolute negative mass. Obesity instead BMI. management can accurately help elderly prevent against

Язык: Английский

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Association of the oxidative balance score with obesity and body composition among young and middle-aged adults

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Апрель 30, 2024

Objective The oxidative balance score (OBS) is important for determining the cause of obesity and its complications. We aimed to evaluate association between OBS other segmental body composition parameters among young middle-aged U.S. adults. Methods 9,998 participants from National Health Nutrition Examination Survey 2011–2018 were included. Lean mass percentage (LM%) FM% evaluated by dual-energy x-ray absorptiometry. Obesity was defined as ≥25% in men ≥ 35% women. scored 5 pro-oxidant 21 antioxidant factors. Associations quartiles with risk estimated using multivariable logistic regression models. Multivariable linear conducted estimate measures including arm LM%, leg torso whole FM%, total FM%. Results Compared lowest quartile OBS, those highest associated a lower BMI-defined [0.43 (0.36, 0.50)] FM%-related (0.35, 0.52)]. Additionally, negatively limb but positively lean trunk. Conclusion LM% US adults, indicating that adhering an anti-oxidative diet lifestyle management may be beneficial preventing obesity.

Язык: Английский

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New BMI Cut-Off Points for Obesity in Middle-Aged and Older Adults in Clinical Nutrition Settings in Italy: A Cross-Sectional Study

Nutrients, Год журнала: 2022, Номер 14(22), С. 4848 - 4848

Опубликована: Ноя. 16, 2022

Obesity is a major health problem defined as an excess accumulation of body fat (BF). The World Health Organization (WHO) usually relies on mass index (BMI) ≥ 30 kg/m2 indicator obesity. Due to changes in composition that occur across the lifespan, with increase BF and decrease lean mass, we aimed test validity this BMI cut-off point for adiposity middle-aged older adults. This cross-sectional study, composed 4800 adults mixed gender aged between 40 80 years, included (according WHO classification) 1087 normal-weight, 1826 overweight, 1887 obese individuals who were referred Department Biomedicine Prevention, University Rome "Tor Vergata", Italy. sample was then categorized by status based total BF% measured dual-energy X-ray absorptiometry (DXA), best sensitivity specificity attained predicting obesity according receiver operating characteristic curve (ROC) analysis. In real-world clinical setting, new (BMI = 27.27 kg/m2) has been identified guidelines Italy therefore need be revised accordingly.

Язык: Английский

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The Aging Process: A Metabolomics Perspective

Molecules, Год журнала: 2022, Номер 27(24), С. 8656 - 8656

Опубликована: Дек. 7, 2022

Aging process is characterized by a progressive decline of several organic, physiological, and metabolic functions whose precise mechanism remains unclear. Metabolomics allows the identification metabolites may contribute to clarifying aging-regulated pathways. We aimed investigate aging-related serum changes using metabolomics approach. Fasting blood samples from 138 apparently healthy individuals (20−70 years old, 56% men) were analyzed Proton Nuclear Magnetic Resonance spectroscopy (1H NMR) Liquid Chromatography-High-Resolution Mass Spectrometry (LC-HRMS), for clinical markers. Associations profile with age explored via Correlations (r); Metabolite Set Enrichment Analysis; Multiple Linear Regression; Metabolism Breakpoint. The increase was positively correlated (0.212 ≤ r 0.370, p < 0.05) markers (total cholesterol, HDL, LDL, VLDL, triacylglyceride, glucose levels); negatively (−0.285 −0.214, tryptophan, 3-hydroxyisobutyrate, asparagine, isoleucine, leucine, valine levels, but (0.237 0.269, aspartate ornithine levels. These resulted in three enriched pathways: valine, isoleucine degradation, urea cycle, ammonia recycling. Additionally, levels aspartate, explained 27.3% variation, aging metabolism breakpoint occurring after third decade life. results indicate that potentially associated reduced branched-chain amino acid (especially life) progressively increased indicative cycle.

Язык: Английский

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Influence of Body Mass Index (BMI) and Waist–Hip Ratio (WHR) on Selected Semen Parameters

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4089 - 4089

Опубликована: Апрель 25, 2025

Because male obesity may result in reproductive failure, we aimed to examine the possible links among body mass index (BMI), waist–hip ratio (WHR), and basic semen parameters, oxidation–reduction potential of semen, total antioxidant capacity seminal plasma, ability sperm bind hyaluronic acid, DNA fragmentation (SDF). This study was performed on (n = 543) collected from volunteers classified as follows: normal weight (BMI 18.5–24.9 kg/m2), overweight 25.0–29.9 obese ≥ 30.0 with a WHR (<1) or abnormal (≥1). No significant differences standard parameters were found between men BMI those overweight/obesity. However, compared men, had higher SDF prevalence risk for an > 20%. Compared < 1, 1 significantly lower motility, morphology, vitality increased index, In conclusion, greater negative impact conventional than BMI. Both negatively influenced chromatin integrity only. Obesity is factor damage.

Язык: Английский

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Exploring the Relationship Between Sleep Quality, Obesity, and Biochemical Markers in Elderly Outpatients

American Journal of Human Biology, Год журнала: 2025, Номер 37(5)

Опубликована: Май 1, 2025

ABSTRACT Objectives This study aims to investigate the relationship between sleep quality (measured by The Pittsburgh Sleep Quality Index—PSQI), body mass index (BMI), and obesity status, explore whether metabolic factors (e.g., fasting glucose, triglycerides, high‐density Lipoprotein Cholesterol) influence this association in elderly outpatients. Methods A cross‐sectional was conducted on 404 people at Thai Binh Medical University Hospital, Vietnam from October 2023 June 2024. Adults who were 60 years older underwent outpatient evaluations biochemical blood tests recruited through convenience sampling. self‐reported (PSQI), whereas BMI markers measured. Results average PSQI score 11.00 ± 2.68, 22.56 2.36. adults with normal had a significantly higher than those poor ( p < 0.05). rate 13.1%, while syndrome diagnosed 36.4% of participants. Logistic regression revealed that education levels associated increased odds compared primary lower. There no quality, obesity, syndrome. Conclusions level affected quality; however, found or adults. Improving habits should be considered weight management elderly.

Язык: Английский

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Prevalence and Associated Factors of Liver Enzyme Abnormalities Among Bangladeshi Women: A Cross-Sectional Study

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Апрель 4, 2024

Background Liver enzyme abnormalities can indicate underlying liver health issues and are influenced by various factors. This study aimed to investigate the prevalence of their associated factors among nonpregnant nonlactating (NPNL) women in Bangladesh. Methodology A cross-sectional was conducted 251 NPNL Bangladeshi women. Data on demographic, socioeconomic, health-related variables were collected. Logistic regression analysis used determine association between Results The participants determined, with such as age, body mass index (BMI), monthly income, food security status examined. Elevated alanine aminotransferase (ALT) aspartate (AST) levels observed 54 (21.5%) 47 (18.7%) participants, respectively, 116 (46.2%) exhibiting an AST/ALT ratio exceeding 1.71. Food insecurity significantly a higher elevated ALT (24.4% vs. 8.7%, P = 0.02), well low income (18.8%, 14.7% 36.7%, < 0.01) BMI (11% 27.7% 25.6%, 0.02). Similar trends for AST levels. Moreover, exhibited rates at least one abnormal function (15.9% 34.9%, 0.01). revealed significant certain demographic socioeconomic factors, specifically age. Conclusions provides insights into findings underscore importance addressing age mitigating this population. Further research targeted interventions warranted address these concerns effectively.

Язык: Английский

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The effect of intermittent fasting on preventing obesity-related early aging from a molecular and cellular perspective

Journal of Medicine and Life, Год журнала: 2024, Номер 17(3), С. 261 - 272

Опубликована: Март 1, 2024

Obesity is a global health concern owing to its association with numerous degenerative diseases and the fact that it may lead early aging. Various markers of aging, including telomere attrition, epigenetic alterations, altered protein homeostasis, mitochondrial dysfunction, cellular senescence, stem cell disorders, intercellular communication, are influenced by obesity. Consequently, there critical need for safe effective approaches prevent obesity mitigate onset premature In recent years, intermittent fasting (IF), dietary strategy alternates between periods feeding, has emerged as promising holds potential in counteracting aging process associated This article explores molecular mechanisms through which IF affects obesity-related regulates various physiological processes organ systems, liver, brain, muscles, intestines, blood, adipose tissues, endocrine system, cardiovascular system. Moreover, modulates key signaling pathways such AMP-activated kinase (AMPK), sirtuins, phosphatidylinositol 3-kinase (PI3K)/Akt, mammalian target rapamycin (mTOR), fork head box O (FOXO). By targeting these pathways, attenuate phenotypes Overall, offers avenues promoting healthier lifestyles mitigating individuals affected

Язык: Английский

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Hypothalamic microstructure and function are related to body mass, but not mental or cognitive abilities across the adult lifespan

GeroScience, Год журнала: 2022, Номер 45(1), С. 277 - 291

Опубликована: Июль 27, 2022

Abstract Physical, mental, and cognitive resources are essential for healthy aging. Aging impacts on the structural integrity of various brain regions, including hippocampus. Even though recent rodent studies hint towards a critical role hypothalamus, there is limited evidence functional consequences age-related changes this region in humans. Given its central metabolic regulation affective processing connections to hippocampus, it plausible that hypothalamic connectivity associated with decline. We used data n = 369 participants (18–88 years) from Cambridge Centre Ageing Neuroscience repository determine potential microstructure across lifespan. First, we identified as function physical, health compared those findings hippocampal microstructure. Second, investigated relationship resting-state related age well physical health. Our results showed not affected by depressive symptoms (mental health), performance (cognitive comparatively stable lifespan, but body mass (physical health). Furthermore, limbic regions amygdala, nucleus accumbens, suggesting alterations reward systems. demonstrate structure mass, focused neural density dispersion, inflammation. Still, observed effect sizes were small, encouraging detailed investigations individual subunits.

Язык: Английский

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Waist Circumference as a Risk Factor for Non-Alcoholic Fatty Liver Disease in Older Adults in Guayaquil, Ecuador

Geriatrics, Год журнала: 2023, Номер 8(2), С. 42 - 42

Опубликована: Апрель 14, 2023

Non-alcoholic liver steatosis is currently considered an epidemic. It involves a broad spectrum of diseases, in which older adults constitute susceptible group. The aim this study to identify the role waist circumference as risk factor for non-alcoholic fatty disease. Methods: A cross-sectional was carried out 99 who regularly attended five gerontological centers city Guayaquil, Ecuador. variables studied were age, gender, independent life, access complete meals, circumference, and NAFLD diagnosed by ultrasound. Results: significant relationship exists between body mass index, fat percentage. However, only age multivariate logistic regression model. Our results suggest that presence index loses its significance may be protective due adipose tissue loss redistribution. Conclusion: Anthropometric measurements such can used complement indicators NAFLD.

Язык: Английский

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